Gloria Yiu, M.D., Ph.D., delves into the transformative potential of genetic editing technologies in addressing rare immune disorders, with a focus on CD3δ severe combined immunodeficiency (SCID)—a condition characterized by impaired T-cell development and severely compromised immune function. Leveraging her expertise as a physician-scientist, Yiu explores how CRISPR and other precision gene-editing tools can correct genetic mutations at the cellular level, potentially restoring T-cell productio...
Dec 02, 2024•28 min
The infections disease landscape is constantly changing - challenging our standard treatments. Can new - as well as ancient - therapies be the answer? Hear from experts on the cutting edge of phage therapy, HIV/AIDS research and cancer care about what is on the horizon to improve human health. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39982]
Nov 30, 2024•56 min
Examine how what we eat and how we live can promote wellness, enhance immunity, combat age-related diseases, and promote longevity. Gordon Saxe, M.D., Ph.D., and Anthony Lim, M.D., J.D., share a timeless perspective, supported by their own research and clinical experience, on how optimal nourishment, purposeful reflection, health movement, and generosity of spirit can improve age-related conditions and slow the aging process. They present evidence-based recommendations for diet and lifestyle, as...
Nov 26, 2024•1 hr 40 min
John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for trea...
Nov 25, 2024•46 min
How can a healthy microbiome prevent disease? In this program, Dr. Sean Spencer talks about the vast microbial world that lives within our guts — known as the gut microbiome — and how it supports our health. He discusses the current evidence about how to nourish your microbiome to prevent and treat disease. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40074]
Nov 22, 2024•1 hr 25 min
Catriona Jamieson, M.D., Ph.D., discusses pioneering research on cancer and aging in space environments, highlighting how microgravity accelerates cancer cell growth and leads to stem cell exhaustion, genomic instability, and “dark genome” activation. Using innovative tools like nano-bioreactors and artificial intelligence, her team simulates these effects and tracks cellular changes, uncovering how space’s unique conditions drive mutations and alter cellular behavior. They find that stem cells ...
Nov 18, 2024•28 min
What's the secret to supporting a sharp mind at any age? In this program, Dr. Nancy Isenberg discusses the latest science-based practices to promote brain health and resiliency as we age. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40073]
Nov 13, 2024•1 hr 26 min
Through the UniversityLink Medical Science Program (ULMSP), college students from underrepresented and disadvantaged backgrounds who aspire to become future health science professionals develop essential academic and professional skills, benefit from long-term mentoring, and build lasting social and professional networks. Dr. Ramón A. Hernandez highlights how the program fosters family support, instills a culture of academic excellence, and emphasizes the importance of community service, showing...
Nov 13, 2024•17 min
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating t...
Nov 08, 2024•45 min
In the last ten years, we've seen a huge change in our approach to epilepsy surgery. We have more options than ever before for patients with uncontrolled seizures. In this new video, @UCSFHospitals neurosurgeon Edward Chang, MD, provides an overview of the pros and cons of different minimally invasive surgical treatments: laser ablation, responsive neurostimulation, deep brain stimulation and vagal nerve stimulation. We hope that raising awareness about the available options can help more people...
Nov 04, 2024•8 min
Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to te...
Nov 04, 2024•1 hr 13 min
The risk for many chronic diseases is directly linked to metabolic changes in the body and loss of muscle mass often associated with aging. In this program, Dr. Natalie Marshall focuses on the central importance of movement, strength training, and body composition to improve metabolic fitness and tips to help you get started “building muscle for life." Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40071]
Oct 31, 2024•1 hr 21 min
UCSF Neurosurgeon Ethan Winkler, MD, PhD, summarizes the surgical treatment options for patients with brain aneurysms and describes the decision-making process for choosing the best treatment for each individual. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40238]
Oct 28, 2024•7 min
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Oct 28, 2024•21 min
Mind-body medicine (MBM) is an integrative approach that helps people build awareness and develop tools for stress resilience. MBM focuses on the interactions between the mind, body, and behavior to promote health and well-being. Dr. Kavita K. Mishra discusses how MBM interventions have shown beneficial short and long-term impact on physical, mental, social-emotional, and interpersonal well-being. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show I...
Oct 22, 2024•1 hr 23 min
UCSF neurosurgeon Ethan Winkler, MD, PhD, summarizes the surgical treatment options for patients with arteriovenous malformations (AVMs) and describes the decision-making process for choosing the best treatment for each individual. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40237]
Oct 21, 2024•6 min
Researchers in the lab of Edward Chang, MD, at UCSF recorded activity from hundreds of individual neurons across all layers of the cortex while participants listened to spoken sentences. In a study published in Nature on December 13, 2023, the researchers showed that neurons responded to different speech sounds like parts of consonants and vowels, or the pitch of the voice. This work provides the most detailed picture yet of how the human brain processes speech. Series: "UC San Francisco News" [...
Oct 17, 2024•2 min
Explore the captivating realm of brain research at UC San Diego with Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A. Furnari and Khalessi delve into groundbreaking efforts to find new treatments for neurological conditions such as brain tumors, stroke, and brain injuries, bringing hope to patients and their families. Emphasizing ethics, innovation, and patient care, Furnari and Khalessi shed light on the challenges and successes in their quest to unravel the mysteries of the mind. Ser...
Oct 16, 2024•1 hr 4 min
UC Davis researchers are developing innovative technology to help older adults maintain independence while staying connected with loved ones. The new I-Care platform combines task management tools with advanced sensor technology to address challenges like cognitive decline and social isolation while also reducing caregiver burnout. Watch as our experts improve the future of senior care. Series: "UC Davis News" [Health and Medicine] [Science] [Show ID: 40175]
Oct 04, 2024•3 min
Colin Depp delves into the critical role of social connections in our well-being, particularly in the context of aging. Depp explores the impacts of digital versus in-person interactions, the influence of cultural differences on social needs, and the potential health benefits of both deep and superficial connections. Depp also discusses the challenges of loneliness, the effects of grief, and offers practical daily practices to strengthen social ties. Series: "Stein Institute for Research on Agin...
Oct 02, 2024•54 min
A Neuroprosthesis for Speech Decoding and Avatar Control Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40235]
Oct 01, 2024•2 min
Perpetual stress runs us down. But a truly restorative state that alters our bodies at the cellular level can counter this deterioration. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 40226]
Oct 01, 2024•2 min
UCSF researchers have conducted successful trials of an experimental adaptive deep brain stimulation (aDBS) device that responds to a person with Parkinson’s symptoms in real time. Using data techniques and custom algorithms, the device picks up on brain signals that indicate a symptom is developing and delivers just the right amount of electrical stimulation to stop it. The research is a collaboration between UCSF’s Phil Starr, MD, PhD, and Simon Little, MBBS, PhD, in the UCSF Department of Neu...
Oct 01, 2024•3 min
Catherine Yeung, Pharm.D., Ph.D., M.P.H., discusses groundbreaking advancements in kidney-on-a-chip technology, emphasizing its potential to revolutionize human health. She delves into the role of environmental toxins, such as okra toxin A, microplastics, and plasticizers, in contributing to chronic kidney disease, particularly in regions with specific dietary practices. Yeung also addresses the challenges of replicating adult kidney cells from stem cells, which often retain a fetal phenotype, a...
Sep 25, 2024•1 hr 11 min
Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our bo...
Sep 20, 2024•28 min
Fungi play a crucial role in our natural ecosystem. Environmental scientist Danielle Stevenson discusses the great impact fungi can have on soil quality and a healthier food supply. Series: "Wellbeing " [Health and Medicine] [Agriculture] [Show ID: 40174]
Sep 16, 2024•9 min
Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] ...
Sep 11, 2024•1 hr
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on the effects of exercise on brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40062]
Sep 09, 2024•2 min
Human activities can increase levels of harmful microorganisms and pollutants in our water systems that have the potential to make us sick or threaten our food supply. Join microbial ecologist Dr. Sarah Allard as she presents emerging research from Scripps Oceanography that sheds light on seafood-related food borne illnesses. Series: "Jeffrey B. Graham Perspectives on Ocean Science Lecture Series" [Health and Medicine] [Science] [Show ID: 40082]
Sep 02, 2024•9 min
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, and discover actionable steps you can take to protect your brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40061]
Aug 29, 2024•10 min
