A Sickness in the Serum, Part 3: The Search for Immune Complexes

The final episode in this trilogy delves into the advancement in laboratory techniques that allowed for more accurate measurements of immune complexes, leading to studies in the ‘50 and ‘60s that clearly demonstrated the potential pathogenicity of immune complex-mediated disease.

 Brought to you by GSK.

• Intro :20
• Recap and in this episode :40
• The precipitant reaction 3:29
• The antibody story 11:25
• Frank Dixon 18:20
• When did people start using these techniques? 20:15
• On the quest to see if immune complexes are pathogenic 24:09
• Frank Dixon’s findings using radioactive iodine tagging 28:22
• Episode wrap-up 29:00
• Thanks for listening! 32:11

Disclosures: Brown reports no relevant financial disclosures.

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References:

Germuth FG Jr, et al. Johns Hopkins Med J. 1967;120:225-251.

Kano K, Milgrom F. Vox Sanguinis. 1980;38:121-137.

McCluskey RT, et al. J Exp Med. 1960;111:181-194.

Waksman BH. Medicine (Baltimore). 1962;41:93-141.