Note: This podcast is a companion to the Ground Truths newsletter “ A Big Week for GLP-1 Drugs” Eric Topol ( 00:06 ): It is Eric Topol with Ground Truths, and with me today is Dr. Daniel Drucker from the University of Toronto, who is one of the leading endocrinologists in the world, and he along with Joel Habener and Jens Juul Holst from the University of Copenhagen and Denmark, have been credited with numerous prizes of their discovery work of glucagon-like peptide-1 (GLP-1) as we get to know t...
Apr 06, 2024•37 min
Siddhartha Mukherjee is a Professor at Columbia University, oncologist, and extraordinary author of Emperor of All Maladies (which was awarded a Pulitzer Prize), The Gene, and The Song of the Cell, along with outstanding pieces in the New Yorker. He is one of the top thought leaders in medicine of our era. “I have begun to imagine, think about what it would be to be a digital human..”—Sid Mukherjee Eric Topol ( 00:06 ): Well, hello, this is Eric Topol with Ground Truths, and I am delighted to ha...
Mar 29, 2024•47 min
There was so much to talk about—this is the longest Ground Truths podcast yet. Hope you’ll find it as thought-provoking as I did! Transcript, with audio and external links, edited by Jessica Nguyen, Producer for Ground Truths Video and audio tech support by Sinjun Balabanoff, Scripps Research Eric Topol ( 00:00:05 ): This is Eric Topol from Ground Truths, and I am delighted to have with me Holden Thorp, who is the Editor-in-Chief of the Science journals. We're going to talk about Science , not j...
Mar 17, 2024•1 hr 1 min
Transcript Eric Topol ( 00:06 ): Well, hello, this is Eric Topol with Ground Truths and I am absolutely thrilled to welcome Daphne Koller, the founder and CEO of insitro, and a person who I've been wanting to meet for some time. Finally, we converged so welcome, Daphne. Daphne Koller ( 00:21 ): Thank you Eric. And it's a pleasure to finally meet you as well. Eric Topol ( 00:24 ): Yeah, I mean you have been rocking everybody over the years with elected to the National Academy of Engineering and S...
Mar 10, 2024•35 min
“ A few years ago, I might have chuckled at the naiveté of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the foreseeable future.” —Coleen Murphy Transcript with external links Eric Topol ( 00:06 ): Hello, this is Eric Topol from Ground Truths, and I'm just so delighted to have with me Professor Coleen Murphy, who has written this exceptional book, How We Age: The Science of Longevity . It is a phenomenal bo...
Mar 03, 2024•45 min
Transcript with audio and relevant external links, recorded on 6 Feb 2024 Eric Topol ( 00:05 ): Hello, this is Eric Topol with Ground Truths, and I have a remarkable guest with me today, Professor Michelle Monje, who is from Stanford, a physician-scientist there and is really a leader in neuro-oncology, the big field of cancer neuroscience, neuroinflammation, and she has just been rocking it recently with major papers on these fields, no less her work that's been on a particular cancer, brain ca...
Feb 25, 2024•44 min
Jim Collins is one of the leading biomedical engineers in the world. He’s been elected to all 3 National Academies (Engineering, Science, and Medicine) and is one of the founders of the field of synthetic biology. In this conversation, we reviewed the seminal discoveries that he and his colleagues are making at the Antibiotics-AI Project at MIT. Recorded 5 February 2024, transcript below with audio links and external links to recent publications Eric Topol ( 00:05 ): Hello, it's Eric Topol with ...
Feb 13, 2024•29 min
“The history of science, it turns out, is filled with stories of very smart people laughing at good ideas.”—Katalin Karikó Ground Truths podcasts are now available on Apple and Spotify! The list of obstacles that Kati Karikó faced to become a scientist, to make any meaningful discovery, to prevail over certain scientists and administrators who oppressed her, unable to obtain grants, her seminal paper rejected by all of the top-tier journals, demoted and dismissed, but ultimately to be awarded th...
Feb 02, 2024•54 min
Jonathan Howard is a neurologist and psychiatrist who practices at NYU-Bellevue and posts frequently on Science Based Medicine . Transcript, unedited, with links to audio Eric Topol ( 00:05 ): Well, hello, Eric Topol with Ground Truths and I'm really pleased to have the chance to talk with Jonathan Howard today, who is a neurologist and psychiatrist at NYU at Bellevue and has written quite an amazing book published a few months months ago called We Want Them Infected , so welcome Jonathan. Jonat...
Jan 25, 2024•43 min
Azeem Azhar is an award-wining entrepreneur and innovator in technology, especially A.I., a member of the editorial board of Harvard Business Review, and an outstanding communicator which makes him a frequent media guest and often featured in The Economist, WSJ, and Financial Times. Exponential View by Azeem Azhar is chock full of interesting analyses and podcasts on tech and A.I. Here’s his summary of our extended and fun discussion I hope you find our conversation interesting and informative. ...
Jan 18, 2024•1 hr 18 min
A snippet of our conversation below Transcript of our conversation 8 January 2023, edited for accuracy, with external links Eric Topol It’s a pleasure for me to have Liv Boeree as our Ground Truths podcast guest today. I met her at the TED meeting in October dedicated to AI. I think she's one of the most interesting people I’ve met in years and the first time I've ever interviewed a professional poker player who has won world championships and we're going to go through that whole story, so welco...
Jan 13, 2024•36 min
The science to advance our understanding of the aging process—and to potentially slow it down—has made important strides. One of the leading scientists responsible for this work is Professor Tony Wyss-Coray, whose work has particularly focused on brain aging but has implications for all organs. I believe his December 2023 Nature paper on blood proteins that can track aging for 11 of our organs is one of the most important aging reports yet. Here is the audio and transcript of our conversation, r...
Dec 26, 2023•32 min
David Liu is an gifted molecular biologist and chemist who has pioneered major refinements in how we are and will be doing genome editing in the future, validating the methods in multiple experimental models, and establishing multiple companies to accelerate their progress. The interview that follows here highlights why those refinements beyond the CRISPR Cas9 nuclease (used for sickle cell disease) are vital, how we can achieve better delivery of editing packages into cells, ethical dilemmas, a...
Dec 10, 2023•48 min
This is one of the most enthralling and fun interviews I’ve ever done (in 2 decades of doing them) and I hope that you’ll find it stimulating and provocative. If you did, please share with your network. And thanks for listening, reading, and subscribing to Ground Truths. Recorded 4 December 2023 Transcript below with external links to relevant material along with links to the audio ERIC TOPOL ( 00:00 ): This is for me a real delight to have the chance to have a conversation with Geoffrey Hinton....
Dec 08, 2023•37 min
“A.I. is not the problem; it’s the solution.”—Andrew Ng at TED, 17 October 2023 Recorded 21 November 2023 Transcript with relevant links and links to audio file Eric Topol ( 00:00 ): Hello, it's Eric Topol with Ground Truths, and I'm really delighted to have with me Andrew Ng, who is a giant in AI who I've gotten to know over the years and have the highest regard. So Andrew, welcome. Andrew Ng ( 00:14 ): Hey, thanks Eric. It's always a pleasure to see you. Eric Topol ( 00:16 ): Yeah, we've had s...
Nov 21, 2023•32 min
If you care about what you eat, you won’t want to miss this conversation! Chris Van Tulleken is an infectious disease physician-scientist in the UK’s National Health Service who has written a deeply researched masterpiece book on food—ULTRA-PROCESSED PEOPLE. It’s not just about these synthetic and artificial UPF substances, that carry many health hazards, but also about our lifestyle and diet, challenging dogma about low carbs/glycemic index and the impact of exercise. Chris ate an 80% UPF diet ...
Oct 24, 2023•47 min
In July, I reviewed Peter’s Outlive book here in Ground Truths and hoped I’d be able to interview him about my concerns. Here’s that conversation, recorded October 16th. I hope you’ll find it informative and stimulating! The AI generated transcript (unedited) below with links to the audio recording Eric Topol ( 00:01 ): Peter, it's really great to see you. I haven't been chance to visit since early 2020, and you introduced me to Topo Chico as a great way to get carbonated water. Are you still in...
Oct 19, 2023•43 min
Recorded 11 October 2023 Beyond being a brilliant scientist, Fyodor is an extraordinary communicator as you will hear/see with his automotive metaphors to explain genome editing and gene therapy. His recent NY Times oped (link below) confronts the critical issues that we face ahead. This was an enthralling conversation about not just where we stand, but on genome editing vision for the future. I hope you enjoy it as much as I did. Transcript with key links Eric Topol ( 00:00 ): Well for me, this...
Oct 12, 2023•47 min
Dr. Peter Hotez is a veritable force. He has been the tip of the spear among physicians and scientists for taking on anti-science and has put himself and his family at serious risk.Along with Dr. Maria Bottazzi, he developed the Corbevax Covid vaccine —without a patent— that has already been given to over 10 million people, and was nominated for the Nobel Peace Prize. Here an uninhibited, casual and extended conversation about his career, tangling with the likes of RFK Jr, Joe Rogan, Tucker Carl...
Sep 19, 2023•48 min
Few, if any, physician researchers have done more to understand the long-term impact of Covid than Dr. Ziyad Al-Aly, a professor, nephrologist, and epidemiologist along with his team at Washington University, St. Louis. Here is the transcript (with links to the audio) of our conversation that was recorded one 7 September 2023. Eric Topol ( 00:00 ): Welcome to Ground Truths, and this podcast is a special one for me. I get to meet professor Dr. Ziyad Ali for the first time, even though we've been ...
Sep 11, 2023•41 min
Eric Topol ( 00:00 ): Hello, this is Eric Topol, and I'm thrilled to have a chance to have a conversation with Magdalena Skipper, who is the Editor-in-Chief of Nature . And a historic note. Back in 2018, she became the first woman editor of Nature in its 149 years, and only the eighth editor of all times. Having taken over for Philip Campbell, who had been previously the editor for 22 years, we're going to ask her if she's going to do 22 or more years, but we're going to have a fun conversation ...
Aug 19, 2023•46 min
Transcript Eric Topol ( 00:00 ): This is a real great opportunity to speak to one of the most impressive medical informaticists and leaders in AI in the United States and worldwide. Dr. John Halamka, just by way of background, John, his baccalaureate in Stanford was at U C S F/Berkeley for combined MD PhD trained in emergency medicine at U C L A. He went on to Harvard where he, for 20 years was the Chief Information Officer at Beth Israel Deaconess. And then in 2020 he joined Mayo Clinic to head...
Aug 11, 2023•34 min
Transcript with Links Eric Topol ( 00:00 ): This is Eric Topol, and I'm so excited to have the chance to speak to Melanie Mitchell. Melanie is the Davis Professor of Complexity at the Santa Fe Institute in New Mexico. And I look to her as one of the real, not just leaders, but one with balance and thoughtfulness in the high velocity AI world of large language models that we live in. And just by way of introduction, the way I got to first meet Professor Mitchell was through her book, Artificial I...
Aug 04, 2023•39 min
Transcript with some hyperlinks Eric Topol ( 00:00 ): Hello, Eric Topol here. And what a privilege to have as my guest Al Gore, as we discuss things that are considered existential threats. And that includes not just climate change but also recently the concern about A.I. No one has done more on the planet to bring to the fore the concerns about climate change. And many people think that the 2006 film, An Inconvenient Truth, was the beginning, but it goes way back into the 1980s. So, Al it's rea...
Jun 21, 2023•34 min
TRANSCRIPT Eric Topol ( 00:00 ): Hello, this is Eric Topol, and it's really a delight for me to welcome Hannah Davis who was the primary author of our recent review on Long Covid and is a co-founder of the Patient-Led Research Collaborative. And we're going to get into some really important topics about citizen science, Long Covid and related matters. So, Hannah, welcome. Hannah Davis ( 00:27 ): Thank you so much for having me. Eric Topol ( 00:29 ): Well, Hannah, before we get into it I thought ...
Jun 06, 2023•42 min
Link to the book: The AI Revolution in Medicine Link to my review of the book Link to the Sparks of Artificial General Intelligence preprint we discussed Link to Peter’s paper on GPT-4 in NEJM Transcript (with a few highlights in bold of many parts that could be bolded!) Eric Topol ( 00:00 ): Hello, I'm Eric Topol, and I'm really delighted to have with me Peter Lee, who's the director of Microsoft Research and who is the author, along with a couple of colleagues for an incredible book called The...
May 22, 2023•43 min
Transcript Eric ( 00:00 ): Okay. Hello, this is Eric Topol and this is a rare privilege for me to interview my favorite epidemiologist, Dr. Michael Osterholm. He is the Regents Professor of the University of Minnesota. He's director of CIDRAP, which is certainly one of the leading entities around the world for public health. And, we've been friends for the last few years, which we'll we'll talk about. So, welcome Michael. Such a great privilege to have you today. Michael ( 00:31 ): Well, thank y...
May 05, 2023•35 min
