In this episode, world-renowned complement expert Carla Nester (University of Iowa) joins Koyal and Kenar to discuss the state of the art in C3 glomerulopathy and other complement-mediated kidney diseases, the opportunities and unknowns of targeted treatments, the recent advances in understanding of all things complement, and how her med/peds specialization brings additional superpowers to her clinical practice. Dr. Nester is an adult and pediatric nephrologist, currently serving as Professor of...
Jul 14, 2025•22 min•Ep. 9
In this special NephMadness 2025 episode, Koyal and Kenar do a deep dive into the Genetics region with NephMadness executive team member Elena Cervantes (Johns Hopkins), genetics expert Jordan Nestor (Columbia) and region writer Matt Gross (Johns Hopkins). Genetics in FSGS faces off vs. Genetic Counseling! What’s new in our ever-expanding knowledge of FSGS genetics? Where does APOL1 fit in? How should we be counseling patients before and after genetic testing, and are we actually getting the tra...
Mar 07, 2025•25 min•Ep. 8
In this special bonus episode of the podcast, Koyal and Kenar provide a maximally useful review of minimal change disease, from diagnosis (including secondary causes to screen for) to treatment options, including how to decide which patients may do better with which therapies. Can’t get enough minimal change? Check out Episode 6 (with Astrid Weins) and Episode 7 (with Felicitas Hengel and Nicola Tomas) for more on the potential role of anti-nephrin autoantibodies in MCD. References KDIGO guideli...
Sep 15, 2024•25 min
SHOW NOTES In this episode, Koyal and Kenar recap everything you need to know about IgAN for the board exam (or just to refresh yourself on the current state of knowledge) — from pathophysiology to treatment decisions. They also discover that nobody is really sure how to pronounce Peyer’s patches (hey, don’t blame us, they’re all the way over in the ileum) so make sure you read the show notes to settle that mystery and check out additional resources! Board Review Bonus #1 - IgA Nephropathy Onlin...
Jul 15, 2024•28 min
In this episode, we talk with Dr. Felicitas Hengel, MD and Dr. Nicola Tomas, MD (both at the University Medical Center Hamburg-Eppendorf) about their groundbreaking anti-nephrin autoantibody research that was just presented at the 2024 ERA Congress and published in the New England Journal of Medicine. Is this a game-changer for minimal change? How could this new understanding change diagnosis and treatment in the future? Are anti-nephrin autoantibodies the next PLA2R? What are the next steps for...
Jun 05, 2024•16 min•Ep. 7
In this episode, Kenar and Koyal interview Dr. Astrid Weins, MD, PhD, about nephropathology, new approaches to solving the mysteries of nephrotic syndrome, and her research on anti-nephrin antibodies in minimal change disease. Dr. Weins is Chief of Integrated Renal Pathology at Mass General/Brigham and an Assistant Professor of Pathology at Harvard. Interested in this topic? Stay tuned for additional new research on anti-nephrin antibodies that will be presented in a Late-Breaking Clinical Trial...
May 17, 2024•17 min•Ep. 6
In this episode, Kenar and Koyal talk with Dr. Jula Inrig about endothelin physiology and different approaches to endothelin antagonism, trials of sparsentan in IgAN and FSGS, the art and science of clinical trial design, career paths in clinical research outside academia, and how we got to our current era of plentiful nephrology clinical trials. Disclosure: Jula Inrig is the Chief Medical Officer of Travere Therapeutics, which is one of multiple corporate partners that provide financial support...
Apr 26, 2024•25 min•Ep. 5
It's March, and that means it's time for NephMadness! Every year, our friends at AJKDBlog pit 16 unique regions of nephrology against each other in a basketball-style tournament. Prepare for the Preeclampsia region by listening to this special episode, where Anna Burgner from Vanderbilt University joins Kenar and Koyal to discuss recent discoveries in preeclampsia (the world's most common glomerulopathy). Will the victor be Diagnosis and Treatment of Preeclampsia, or Risk Factors, Prevention, an...
Mar 01, 2024•20 min•Ep. 4
We talk with Dr. Opeyemi Olabisi , MD, PhD, about the history and future of APOL1-mediated FSGS, the role of clinical researchers in building trust with patients, his innovative CARE and JUSTICE programs to bring kidney health screenings and research opportunities to the underrepresented African American community, and why his expertise as an MD/PhD in molecular biology led him to also become a leader in community engagement. The JAK-STAT pathway gets some love as well! Dr. Olabisi's research an...
Jan 11, 2024•15 min•Ep. 3
In this episode of GN in Ten, Koyal and Kenar take the show on the road to Kidney Week to ask attendees about their favorite glomerular diseases. Listen closely for a surprise Shakespearean crossover!
Nov 22, 2023•11 min•Ep. 2
International Society of Glomerular Disease President Prof. Dr. Tobias B. Huber of the University Medical Center Hamburg-Eppendorf discusses the mission of the society and his vision for the future of glomerular disease. More information on the Hamburg Center for Kidney Health Creators & Guests Kenar Jhaveri - Host Koyal Jain - Host Tobias B. Huber - Guest Laurel Damashek - Producer...
Sep 19, 2023•11 min•Ep. 1
Welcome to GN in Ten from the International Society of Glomerular Disease! In this trailer, our hosts Dr. Kenar Jhaveri and Dr. Koyal Jain introduce themselves and the podcast. Learn more about the International Society of Glomerular Disease (ISGD) at is-gd.org .
Sep 02, 2023•2 min
