Tech Blast | Organ-on-a-chip models of fatty liver disease

In this Tech Blast episode, we discuss preclinical models of non-alcoholic fatty liver disease with Gareth Guenigault, Lead Scientist of Services at CN Bio (Cambridge, UK). Gareth provides an overview of non-alcoholic steatohepatitis (NASH) therapeutic landscape and explains how incorporating organ-on-a-chip models into drug discovery workflows can improve this landscape. Get Gareth’s expert insight into the field and discover how to develop liver-on-a-chip NASH models, tips for analyzing the resultant data, and the future of organ-on-a-chip technologies. Contents: Introduction: 00:00–00:30 Pathology and prevalence of NASH: 00:30–01:50 Challenges faced when developing drugs for NASH: 01:50–03:40 An overview of organ-on-a-chip models: 03:40–05:05 Liver-on-a-chip models for NASH: 05:05–07:05 Incorporating organ-on-a-chip into drug discovery workflows: 07:05–08:45 Accessing liver-on-a-chip and NASH models: 08:45–09:45 The NASH-in-a-box workflow: 09:45–10:45 Gareth’s tips for analyzing the data: 10:45–12:15 The future of organ-on-a-chip technology: 12:15–13:55