In this episode of FOMO Investing , Brian O’Neill and Mikhail Bulchandani do a deep dive into one of Brian’s favorite stocks, TG Therapeutics (TGTX). Brian outlines his multi-year investment thesis in TGTX, from its setbacks in oncology to its successful commercialization of Briumvi (ublituximab) for relapsing forms of multiple sclerosis. What You’ll Learn: TG Therapeutics’ evolution to a successful commercial-stage biotech. Practical investment strategies for investing in biotech companies like...
Jul 16, 2025•45 min•Ep. 15
In this episode of FOMO Investing, Brian and Mik dive into the volatile world of Carvana, exploring its business model, recent stock performance, and the ongoing debate between short and long theses. Mik shares his personal experience selling cars to Carvana during the pandemic, leading into a discussion about the company's unique approach to the used car market. They analyze Carvana's operational efficiencies, the controversy surrounding related-party transactions, and the potential future of o...
May 27, 2025•42 min•Ep. 14
For the lucky no. 13 episode of FOMO Investing , we explore the powerful yet often misunderstood force of "Fear of Missing Out" (FOMO) in investing. We unpack the psychology behind why investors often feel compelled to act impulsively and discuss how some legendary investors harness this instinct to their advantage. We explore how to turn the urge to act into a structured process that maximizes your edge without succumbing to panic or peer pressure.
May 17, 2025•47 min•Ep. 13
In this episode, we develop our Theory Of The Case (TOTC) on the ANSYS + Synopsys merger. We cover the potential upside from the deal. Why ANSYS + Synopsys could be the backbone of Physics AI. The merger arbitrage opportunity and lessons from past trades (hello, Rite Aid 👀) Key Topics Covered: 🧠 What ANSYS and Synopsys actually do and why they matter 💻 CAE + EDA: how the merger creates an end-to-end design environment 🤖 Physics AI : the untapped potential of generative models trained on phys...
Apr 16, 2025•34 min•Ep. 12
In this episode of FOMO Investing , we dive into the full story of Checkpoint Therapeutics , a microcap biotech that just entered into an agreement to be acquired by Sun Pharma. Brian walks us through his personal “theory of the case”—from early conviction to final outcome—including investor psychology, capital efficiency, clinical development hurdles, and what the CVRs (Contingent Value Rights) might still deliver post-deal. We explore the science behind Checkpoint UNLOXCYT™. How Checkpoint nav...
Apr 11, 2025•39 min•Ep. 11
An update to our Theory of The Case (TOTC) on IonQ ~ mid-January 2025. We review Jensen Huang's and Mark Zuckerburg's claims about the timeline for useful quantum computing (being 15+ years out). We also include IonQ management responses, including the CFO's (Thomas Kramer) view. We reflect on the current state of play of AI and the potential role for Quantum computing.
Mar 25, 2025•40 min•Ep. 10
In this end-of-year episode, Brian and Mik explore the evolution of Bitcoin—from its mysterious beginnings with Satoshi Nakamoto’s 2008 white paper to its current six-figure price. They discuss how Bitcoin’s role has shifted from “electronic cash” to a potential reserve asset, the concept of “digital real estate,” and whether it truly lives up to its promise of decentralization. They also discuss skepticism by prominent figures like Charlie Munger and Jamie Dimon, debate energy usage, and consid...
Jan 13, 2025•49 min•Ep. 9
In this episode, we unpack the latest developments at Intel following the sudden resignation of CEO Pat Gelsinger. In this Theory Of The Trade (TOTT) episode, we recount why Mik initially started investing in Intel when Pat Gelsinger rejoined the company (~ February 2021) and why he is now cutting his exposure to the stock, given the uncertainty overhang after Pat’s departure. We explore Intel’s storied past—from the 386/486 “glory days” to missed opportunities in mobile—and dissect whether Inte...
Dec 30, 2024•34 min•Ep. 8
In this episode of FOMO Investing , we develop our Theory Of The Case (TOTC) on IonQ (IONQ). In TOTC episodes, we have an open-ended discussion on an investment that we are beginning to research. We dive into the fundamentals, the opportunity, and ultimately whether we believe there is a good investment thesis. IonQ is one of the few pure play quantum compute companies. IonQ is working on developing and scaling general purpose quantum compute. In this episode we discuss what is quantum compute, ...
Nov 26, 2024•37 min•Ep. 7
In this episode of FOMO Investing , we unpack the outcome of the 2024 elections from a betting market, polling data, and what biases might explain what made them get the odds on the outcome quite wrong. We touch on topics like the wisdom of crowds, the efficient market hypothesis, and how these new betting markets could hedge traditional financial markets. We discuss whether betting on elections is a legitimate hedging tool or just a gamified gamble. We discuss what may have driven poll bias. Ho...
Nov 19, 2024•38 min•Ep. 6
In this episode of FOMO Investing , we develop our Theory Of The Case (TOTC) on Viking Therapeutics (VKTX). In TOTC episodes, we have an open-ended discussion on an investment that we are beginning to research. We dive into the fundamentals, the opportunity, and ultimately whether we believe there is a good investment thesis. Viking Therapeutics (VKTX) has become a fast follower in the rapidly growing GLP-1/obesity drug market. We discuss the current state of play of VK-2735 research and Phase 2...
Nov 08, 2024•47 min•Ep. 5
In this episode of FOMO Investing , we kick off Q42024 with a chat about market indices and the pros and cons of index funds. We discuss index funds and how Vanguard / Jack Bogle started a trend toward low-cost index funds. We discuss active management as compared with passive index fund investing. We discuss the incentives in fund management that drive asset managers to end up with diversified asset allocations that are closely correlated with indices. We challenge the conventional wisdom of "s...
Nov 08, 2024•32 min•Ep. 4
In this episode of FOMO Investing , Brian and Mik discuss the nuances of risk management in investing, the role of position sizing, and the pros and cons of using leverage. They share personal stories and frameworks for understanding risk, explore the balance between diversification and concentration, and provide practical tips on how to approach investments with a thoughtful mindset. They draw from legendary investors like Charlie Munger/Warren Buffet and Nomad Capital (Nick Sleep). References:...
Nov 08, 2024•45 min•Ep. 3
Episode Summary: In this episode of FOMO Investing , Brian and Mik discuss the role of CEOs in determining the success of companies. They explore whether a CEO's leadership matters more than the industry's inherent economics. Drawing parallels with iconic leaders like Steve Jobs, Tim Cook, and Mark Zuckerberg, the discussion highlights how different leadership styles impact innovation, company culture, and strategic decision-making. The conversation also touches on investment strategies and the ...
Nov 08, 2024•34 min•Ep. 2
In this episode, Mik and Brian discuss the concept of FOMO investing and how to develop a principled approach to investing. They explore the current state of the market, the valuation of tech stocks, and the significance of Warren Buffett's decision to reduce his exposure to Apple. They also touch on the topics of AI, compute, and the potential opportunities and risks they present. The conversation highlights the importance of understanding one's edge as an investor, recognizing the difference b...
Oct 04, 2024•30 min•Ep. 1
