Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06

Identification and manipulation of molecules regulating axonal outgrowth and synapse formation during post-injury axonal remodeling

Analysis of Dscam1 diversity in regulating dendritic morphology of Lobula Plate Tangential Cells

In arthropods like Drosophila, Down syndrome cell adhesion molecules (Dscam1) exhibit enormous molecular diversity. A single Dscam1 gene encodes a large superfamily of neuronal cell recognition proteins that control neuronal outgrowth and anatomy. A comparable function is exhibited by the vertebrates DSCAMs of which only few isoforms exist. However, it is largely unknown, if and how this function of Dscams affects neuronal function and the control of behavior by the nervous system. In this thesi...

The LytS/LytTR-like histidine kinase

FKBP51 at the interface of stress and psychiatric disorders

Systematic analysis of lysine acetyltransferases

Characterization of the protein import pathway in pea chloroplast

In order to sustain their structure and metabolism, chloroplasts and other plastid types must import the majority of their proteins from the cytosol across the envelope membrane. Translocation of these precursor proteins across the double envelope membrane is achieved by two multimeric complexes - the so-called TOC and TIC complexes (Translocon at the Outer envelope of Chloroplast and Translocon at the Inner envelope of Chloroplast, respectively). N-terminal transit peptides essential for import...

Characterization of a sensory complex involved in antimicrobial peptide resistance

In their habitats, microorganisms are often in competition for limited nutrients. In order to succeed, many Gram-positive bacteria resort to production of peptide antibiotics. Therefore, resistance mechanisms against these compounds are essential. The first step of ensuring survival is the perception of the harmful drugs and mediation of resistance against it. In recent years, a group of ABC-transporters have been recognized as important resistance determinate against antimicrobial peptides. The...

Visual system of basal Chelicerata

Neural circuits underlying colour vision and visual memory in Drosophila melanogaster

Focusing at the fly visual system I am addressing the identity and function of neurons accomplishing two fundamental processing steps required for survival of most animals: neurons of peripheral circuits underlying colour vision as well neurons of higher order circuits underlying visual memory. Colour vision is commonly assumed to rely on photoreceptors tuned to narrow spectral ranges. In the ommatidium of Drosophila, the four types of so-called inner photoreceptors express different narrow-band...

A new circuit for visual memory formation

Neural circuits mediating aversive olfactory conditioning in Drosophila

For all animals it is highly advantageous to associate an environmental sensory stimulus with a reinforcing experience. During associative learning, the neural representation of the sensory stimulus (conditioned stimulus; CS) converges in time and location with that of the reinforcer (unconditioned stimulus; US). The CS is then affiliated with a predictive value, altering the animal’s response towards it in following exposures. In my PhD thesis I made use of olfactory aversive conditioning in Dr...

Kinetic properties of heteromeric kinesin-2 from Caenorhabditis elegans

The planar cell polarity regulator Flamingo cooperates with Netrin/Frazzled signaling during axon targeting in the Drosophila embryonic CNS

Sensing and retrograde signalling of mitochondrial metabolic states in plants

Wechselwirkung immunmodulatorischer Zellen mit vaskulären Endothelzellen

The role of ORC6 in the human cell

Orc6 is a crucial component of the replication initiation machinery in eukaryotes. Its study helps us to better understand one of the most basic cell functions: DNA replication. The first step in replication initiation is the assembly and DNA binding of the origin recognition complex (ORC). Although members of ORC are highly conserved and well studied, Orc6 evolved faster than the other members of the complex, has a different structure and is less well understood than Orc1-5. The low number of s...

Developmental adaptations of energy and lipid metabolism in Trypanosoma brucei insect forms

Continuous quantification of transcription factor dynamics in individual hematopoietic stem and progenitor cells

Wie realitätsnah sind klassisch-anthropologische Proxydaten wirklich? Der Testfall einer Skelettserie aus der Zeit des demographischen Übergangs

Während prähistorische, römische, frühgeschichtliche und mittelalterliche Skelettfunde seit jeher das Untersuchungsgut der physischen Anthropologie mit dem Ziel der Rekonstruktion von menschlicher Bevölkerungsentwicklung in Zeit und Raum darstellt, ist die anthropologische Bearbeitung neuzeitlicher und insbesondere spätneuzeitlicher Skelettserien bis heute weltweit sehr selten, was u. a. mit deren Verfügbarkeit zu begründen ist, denn in der Regel ist die Wiederbestattung der Skelette bei lebende...

Genome engineering of the magnetosome island in Magnetospirillum gryphiswaldense

The neuronal cell adhesion molecules NCAM and Neuroligin-2 link stress vulnerability and social behavior

Neuronal cell adhesion molecules have recently been put into the spotlight of preclinical and clinical research as potential candidates for the mediation of stress effects on brain function and behavior. The stress-induced remodeling of neuronal circuits for structural and functional changes is triggered by the reorganization of synaptic connections, a process that is potentially mediated by neuronal cell adhesion molecules. Disturbances in neuronal connectivity, induced by genetic and/or enviro...

Intravitalmikroskopische Studien im Mausmodell mit kraniellen Fenstern: Fluoreszenzdarstellungen bei der Diagnostik und antiangiogenen Therapie von Gehirntumoren

Die Bedeutung des Transkriptionsfaktors Sox2 für die Entwicklung des Kleinhirns und die Entstehung von Medulloblastomen

Remorin proteins in Arabidopsis thaliana

Die Plasmamembran lebender Zellen stellt die Hauptbarriere für alle Arten von extrazellulären Signalen dar. Viele davon werden ins Innere der Zelle weitergeleitet, hier lösen sie im Kern transkiptionelle Veränderungen und damit die Anpassung der Zelle auf Proteinebene aus. Andere wiederum werden direkt erkannt und in unmittelbare molekulare Antworten umgewandelt, wie zum Beispiel die Sekretion von gespeicherten Stoffen oder Konformations-änderungen von Proteinen. Besonders in Pflanzen, welche d...

Proteomic analysis of specific chromatin domains containing the histone variants H2A.Bbd and macroH2A.1.2

Morphology and evolution of Malacostraca

In this dissertation project comparative morphological studies on the nervous system, mandible structure and sensory equipment of Decapoda and Peracarida are presented and interpreted with regard to the evolution of the taxa. This is a cumulative dissertation and the results were obtained in several separate publications. Both larval and adult characters as well as the ontogeny of certain features were included and analysed using various sets of imaging techniques ranging from conventional light...

Characterization of H3K56me3, a novel histone core modification

Transfer humanpathogener Bakterien auf Salat und Gemüse bei biologischem Anbau

Evolution of genes related to temperature adaptation in Drosophila melanogaster as revealed by QTL and population genetics analyses

The fixation of beneficial variants leaves genomic footprints characterized by a reduction of genetic variation at linked neutral sites and strong, localized allele frequency differentiation among subpopulations. In contrast, for phenotypic evolution the effect of adaptation on the genes controlling the trait is little understood. Theoretical work on polygenic selection suggests that fixations of beneficial alleles (causing selective sweeps) are less likely than small-to-moderate allele frequenc...

Transport of metabolites in chloroplasts