2. Are proton pump inhibitors associated with dementia?

In this episode, you will find a comparative analysis of observational, meta-analytic, and trial-based evidence on proton pump inhibitors and the risk of dementia.

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References:

-Paper #1: Zhang P, Li Z, Chen P, Zhang A, Zeng Y, Zhang X, Huang Q, Liu D, Qi S, Mao C. Regular proton pump inhibitor use and incident dementia: population-based cohort study. BMC medicine. 2022 Sep 1;20(1):271.

Link: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02478-y

-Paper #2: Caetano C, Veloso M, Borda S. Proton pump inhibitors and dementia: what association? Dementia & Neuropsychologia. 2023;17.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229084/

-Paper #3: Mehta RS, Kochar B, Zhou Z, Broder JC, Chung P, Yang K, Lockery J, Fravel M, Ryan J, Mahady S, Orchard SG. Association of Proton Pump Inhibitor Use With Incident Dementia and Cognitive Decline in Older Adults: A Prospective Cohort Study. Gastroenterology. 2023 Sep 1;165(3):564-72.

Link: https://www.gastrojournal.org/article/S0016-5085(23)00873-9/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F