17. What is the contribution of genetics to suicide?
Episode description
In this episode: Suicidal behaviors and thoughts, along with their tragic consequences, have been the subject of scientific investigation across the globe. Genetics is a burgeoning field of research in this context, with studies increasingly probing the intricate relationships between genetic markers, epigenetic factors, and predispositions towards self-harm and suicidal tendencies. The following is a comparative review of three paramount studies in this area.
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References:
1- Li QS, Shabalin AA, DiBlasi E, Gopal S, Canuso CM, FinnGen, International Suicide Genetics Consortium, Palotie A, Drevets WC, Docherty AR, Coon H. Genome-wide association study meta-analysis of suicide death and suicidal behavior. Molecular psychiatry. 2023 Feb;28(2):891-900.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908547/
2- Erlangsen A, Appadurai V, Wang Y, Turecki G, Mors O, Werge T, Mortensen PB, Starnawska A, Børglum AD, Schork A, Nudel R. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Molecular Psychiatry. 2020 Oct;25(10):2410-21.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515833/
3- Mirza S, Docherty AR, Bakian A, Coon H, Soares JC, Walss‐Bass C, Fries GR. Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2022 Oct;189(7-8):221-46.