11. LDL cholesterol levels, outcomes, and mortality.

In this episode find a summary that synthesizes three key papers that explore the relationship between LDL-C and various health outcomes, primarily focusing on mortality.

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References:

1. Johannesen CD, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. Bmj. 2020 Dec 8;371.

Link: https://www.bmj.com/content/371/bmj.m4266.long

2. Navarese EP, Robinson JG, Kowalewski M, Kołodziejczak M, Andreotti F, Bliden K, Tantry U, Kubica J, Raggi P, Gurbel PA. Association between baseline LDL-C level and total and cardiovascular mortality after LDL-C lowering: a systematic review and meta-analysis. Jama. 2018 Apr 17;319(15):1566-79.

Link: https://jamanetwork.com/journals/jama/fullarticle/2678614

3. Ennezat PV, Guerbaai RA, Maréchaux S, Le Jemtel TH, François P. Extent of Low-density Lipoprotein Cholesterol Reduction and All-cause and Cardiovascular Mortality Benefit: A Systematic Review and Meta-analysis. Journal of Cardiovascular Pharmacology. 2023 Jan;81(1):35.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812424/