Podcast # 478: Psychedelics and Depression
Jun 14, 2019•3 min
Listen to this episode in Metacast mobile app
Don't just listen to podcasts. Learn from them with transcripts, summaries, and chapters for every episode. Skim, search, and bookmark insights. Learn more
Episode description
Author: Chris Holmes, MD
Educational Pearls:
- Hallucinogenic drugs have been in use since ancient times for both medical and recreational purposes
- Ayahausca is an ancient psychedelic with origins in Bolivia that causes intense vomiting followed by a psychedelic experience
- This and other hallucinogens are gaining gaining interest for their use in depression with some startling positive initial results
References
Carhart-Harris RL et. al. Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology (Berl). 2018 Feb;235(2):399-408. doi: 10.1007/s00213-017-4771-x. Epub 2017 Nov 8. PubMed PMID: 29119217; PubMed Central PMCID: PMC5813086.
Palhano-Fontes F et. al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med. 2019 Mar;49(4):655-663. doi: 10.1017/S0033291718001356. Epub 2018 Jun 15. PubMed PMID: 29903051; PubMed Central PMCID: PMC6378413.
Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD
For the best experience, listen in Metacast app for iOS or Android