In this episode, we discuss recently published practice-changing trials RECOVERY and REMAP-CAP. These trials have clearly demonstrated the difference in mortality with the use of Tocilizumab in severe COVID-19.
Join us to dive deeper into the recent controversy around oxygen therapy and its proposed targets in ICU patients. In this episode, we compare 3 landmark trials namely ICU-ROX, LOCO2 and HOT-ICU along with recently published meta-analyses to fully understand the nature of this controversy and discuss our recommendations for the future.
In this podcast, we discuss the challenges and the evidence behind different technological platforms used to produce COVID-19 vaccines.
The year 2020 has been a challenging year for most of us. We all are eagerly waiting to get out of this pandemic. Recently published trial on COVID-19 vaccine has offered some hope, however its too soon to predict the outcome.
High lactate levels are uniformly associated with poor clinical outcomes, including mortality. However, there is considerable interest and conflict of opinion regarding the clinical value of using lactate levels to guide resuscitation in critically ill patients. In this episode, we dive deeper into this long-standing controversy.
Join us in this episode, where we discuss the recently published trial in JAMA. This trial explores the efficacy of regional citrate anticoagulation over systemic heparin anticoagulation for CRRT. This is the largest randomised controlled trial on this topic and has provided very valuable answers on this topic.
In this episode, we discuss some of the controversial recommendations from surviving sepsis guidelines and talk about the rational approach in adopting these guidelines.
In this episode, we discuss what the importance of guidelines is, how they are formed and what does GRADE methodology involve.
In this episode, we dive deeper to understand how to interpret a meta-analysis, which is usually situated at the top of the pyramid of Evidence-based medicine.
In this podcast, we discuss how one should interpret an RCT, which is considered as the gold standard while practising evidence-based medicine.
The role of steroids in COVID-19 has been endorsed after the publication of RECOVERY trial. However, whether we should change our practices based on just one trial was heavily debated. In this podcast, we discuss the role of steroid in COVID-19 in-depth and weigh all the available evidence on this topic.
Prone positioning was first proposed in the 1970s as a method to improve gas exchange in ARDS. Subsequent observations of dramatic improvement in oxygenation with simple patient rotation motivated the next several decades of research. During COVID -19 pandemic, the debate on the utility of proning has been resurfaced. In this podcast, we dive deeper to discuss the physiology and evidence behind the role of proning in ARDS.
In this podcast, we discuss a recently published landmark trial START-AKI trial. This trial explores the benefit of accelerated renal replacement strategy compared to standard strategy.
Join us in our Golden jubilee episode, where we discuss top 10 trials published in last two decades that helped to change the practices in Intensive care.
The cytokine storm, arising from a dysregulated host response, has captivated mainstream and scientific media in recent times with its possible role leading to poor outcomes in COVID-19. It is characterized by the release of mediators, including chemokines, interleukins, interferons, and tumor necrosis factors. In this podcast, we discuss the available evidence on this topic.
Tranexamic acid has been thought to be the wonder drug for stopping the active bleeding and has recently been proven life-saving in certain subgroups of patients. HALT_IT is another landmark trial that has evaluated the benefit of tranexamic acid in patients with acute GI bleeding. In this podcast, we discuss the implications of this landmark trial.
Recently published RCT in NEJM has raised more questions on the use of HCQ for post-exposure prophylaxis in COVID-19. This trial is more provocative than definitive. In this podcast, we discuss this trial in-depth and present our views on this topic.
The majority of guidelines for COVID-19 recommended against the use of steroids. However, RECOVERY trial has challenged this opinion by proving that low dose dexamethasone can actually improve the outcomes by both decreasing the mortality and facilitating early discharge from the hospital. In this podcast, we discuss the implications of this landmark trial on the future of this deadly pandemic.
The routine use of Vit D in critically ill patients is debatable. The VIOLET trial published in NEJM in December 2019 has given us some clear answers on this topic. In this podcast, we discuss this trial in-depth to outline future directions on this topic.
Management of ARDS comprises of multi-modal approach that includes pharmacological and non-pharmacological interventions. The evidence on non-pharmacologic interventions is consistent. However, the benefit of pharmacological interventions is still debatable. In this podcast, we critically evaluate the role of neuromuscular blockade in ARDS.
The recently published trial in JAMA has suggested that the treatment with convalescent plasma in COVID-19 is feasible and can be used as a potential treatment option in this devastating pandemic.
In this episode, we discuss another landmark trial published in NEJM on the use of Remdesivir in COVID-19. This trial has raised more questions than providing answers.
In this podcast, we discuss multi-national registry data on the efficacy of chloroquine, hydroxychloroquine with or without macrolides in COVID-19 patients. This study has added significant information to our understanding of COVID-19 and has warned us against the use of the combination of HCQ and macrolides.
COVID-19 pandemic has posed a very difficult challenge to the entire ICU community i.e. how to prevent transmission to health care workers while performing routine interventions in critically ill patients. This has forced us to unlearn the traditional ways and learn new ways of performing certain interventions in ICU. In this podcast, we discuss specific modifications that every ICU staff need to be aware of while caring for COVID-19 patient.
Remdesisvir has thought to be the new CURE for COVID-19. In this podcast, we discuss the recent evidence available on the efficacy of Remdesivir in COVID-19.
The literature published from various countries has helped us to understand the disease pattern in COVID-19 pandemic. In this podcast, we discuss the key literature from New York, Italy, China and the UK.
In this episode, we summarise the key literature published in last week w.r.t novel therapies in COVID-19.
In this podcast, we discuss current controversies w.r.t treatment of COVID -19 patients and summarise the literature available till date.
In this podcast, we discuss how to manage critically ill patient diagnosed with COVID-19. This podcast based on current recommendations from various societies and the expressed views may change as recommendations change over time.
Vasopressor administration to maintain higher map in patients >65 years of age has become a dogma. In this podcast, we discuss recently published 65 trial which not only challenges this dogma but will definitely change our practices.
