Oncometabolites and The Heart
Feb 21, 2024•18 min
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Episode description
Oncometabolites and The Heart
Dr RR Baliga 'Got Knowledge Doc' PodKasts for Cardio-Oncologists
Baliga RR, Young JB. Energizing Diastole Heart Fail Clin. 2008;4(1):ix‐xiii.
Sulkowski, P.L., Oeck, S., Dow, J. et al. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature (2020).
Tumour metabolites hinder DNA repair Krebs Cycle Nobel Lecture Ivosidenib and Cardiogenic Shock Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev. Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer. J Cardiovasc Transl Res. Krebs Cycle Primer Khan AcademyTaegtmeyer H, et al Oncometabolic Tracks in the Heart. Circ Res. 2017
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