Acute hearing loss can be an early sign of posterior circulation stroke, particularly in anterior inferior cerebellar artery (AICA) infarctions. However, hearing assessments are often overlooked due to the NIH Stroke Scale’s focus on anterior strokes. Real-world data showed missed diagnoses of vascular events when hearing loss was not evaluated. Integrating portable audiometry into stroke protocols could improve diagnostic accuracy and lead to timely interventions.
Feb 22, 2025•2 min
Three recent trials investigated the effectiveness of endovascular treatment (EVT) in ischemic stroke. The OPENS-2 trial (Lancet 2025) found that normobaric hyperoxia combined with EVT improved 90-day functional outcomes for large-vessel occlusion stroke without increasing adverse events. The DISTAL trial (NEJM 2025) reported no significant benefit of EVT over medical therapy for medium/distal vessel occlusions and noted a higher risk of hemorrhage. Similarly, the ESCAPE-MeVO trial (NEJM 2025) f...
Feb 21, 2025•4 min
🚨 VANISH2 Trial Alert! 🚑💙 Catheter ablation 🩺 proves superior to antiarrhythmic drugs 💊 for ventricular tachycardia in ischemic cardiomyopathy, reducing ICD shocks & VT storms! ⚡⬇️ #Cardiology #Electrophysiology #VT #ICD @NEJM
Feb 20, 2025•3 min
The Endocannabinoid System plays a crucial role in regulating cardiovascular, neurological, and immune functions through CB1 and CB2 receptors . • CB1 Activation : Associated with oxidative stress , inflammation , and increased cardiovascular risks such as myocardial infarction (MI) , arrhythmias , and heart failure . • CB2 Activation : Primarily found in immune cells and linked to anti-inflammatory and protective cardiovascular effects . • Cannabis Use : High THC content or synthetic cannabinoi...
Feb 20, 2025•6 min
The SUMMIT trial investigated tirzepatide , a dual GIP and GLP-1 receptor agonist, in 731 patients with HFpEF and obesity . This randomized, placebo-controlled study found that tirzepatide reduced heart failure-related events (HR 0.62, P=0.026) and significantly improved quality of life (KCCQ-CSS +19.5 vs. +12.7, P<0.001) . However, cardiovascular mortality was not significantly different . Gastrointestinal side effects led to a 6.3% discontinuation rate . The findings suggest a potential rol...
Feb 19, 2025•3 min
Summary on Kaṇāda Kaṇāda, also known as Ulūka or Kashyapa, was an ancient Indian natural philosopher and the founder of the Vaisheshika school of Indian philosophy. He is often regarded as the earliest proponent of atomism in the world, proposing that the universe is composed of indivisible, eternal atoms ( paramanu ), which combine in various ways to form different substances. His ideas were recorded in the seminal text Vaiśeṣika Sūtra , which outlined a realistic and pluralistic ontology. Esti...
Feb 18, 2025•4 min•Season 1Ep. 1
The study investigates the K210del mutation in genetic cardiomyopathy, which impairs myocardial contractility due to calcium discoordination in the troponin complex. Using a structure-based drug repurposing approach, researchers identified risedronate, an FDA-approved bisphosphonate, as a structural corrector that restores the calcium-binding domain’s normal configuration. Experiments with patient-derived iPSC cardiomyocytes and a mouse model demonstrated that risedronate normalized calcium sens...
Feb 17, 2025•2 min
Recent randomized trials, including EARLY TAVR, AVATAR, RECOVERY, and EVOLVED, suggest benefits of early aortic valve replacement (AVR) in asymptomatic severe aortic stenosis (AS). Early AVR reduces stroke, heart failure hospitalizations, and cardiovascular events, with a trend toward improved survival. The data support shifting from clinical surveillance to early intervention?
Feb 17, 2025•5 min
The EVOLVED trial investigated whether early aortic valve intervention could improve outcomes in asymptomatic patients with severe aortic stenosis and myocardial fibrosis. The randomized, multicenter study of 224 patients found no significant difference in all-cause mortality or unplanned aortic stenosis-related hospitalizations between early intervention and guideline-directed conservative management. However, early intervention was associated with lower rates of NYHA class II-IV symptoms and f...
Feb 17, 2025•2 min
Summary: Cold-Related Deaths in the US (1999–2022) 1. Overview and Trends • Cold-related deaths more than doubled over the study period. • 40,079 deaths recorded; age-adjusted mortality rate (AAMR) rose from 0.44 (1999) to 0.92 (2022) per 100,000 population ( 109% increase ). • A significant upward trend began in 2017 , with an annual percentage change (APC) of 12.1% . 2. Demographic Insights • Age: Mortality was highest among individuals aged ≥75 years (4.23/100,000 in 2022). • Largest Increase...
Feb 16, 2025•2 min
The AZALEA–TIMI 71 trial compared abelacimab , a monoclonal antibody targeting factor XI , with rivaroxaban in atrial fibrillation patients at moderate-to-high stroke risk . 🚨 New study: Abelacimab vs. Rivaroxaban in AFib 📊 ✅ 62-69% lower bleeding risk than rivaroxaban ✅ 5x lower GI bleeding ⚠️ Slightly higher ischemic stroke rates A promising safer anticoagulant? 🔬 More data needed! #CardioTwitter #CardioEd #MedEd Abelacimab significantly reduced bleeding compared to rivaroxaban (HR: 0.38 fo...
Feb 16, 2025•3 min
The Tri.Fr Randomized Clinical Trial evaluated the efficacy of Transcatheter Edge-to-Edge Repair (T-TEER) + Optimized Medical Therapy (OMT) versus OMT alone in 300 patients with severe, symptomatic tricuspid regurgitation (TR) across 24 centers in France and Belgium. At 1-year follow-up , 74.1% of patients in the T-TEER group improved , compared to 40.6% in the OMT-alone group (P < .001) . T-TEER significantly reduced TR severity , improved NYHA class, patient global assessment (PGA), and Kan...
Feb 15, 2025•3 min
Three studies examined the health impacts of aircraft noise exposure. The Heathrow Study (2023) found that nighttime aircraft noise increased cardiovascular events, particularly between 22:00–23:00 and 04:30–06:00, likely due to sleep disturbance and stress-related mechanisms. 🚨 New studies link aircraft noise to serious health risks! 🛩️🔊 📌 Nighttime noise boosts heart disease risk 🫀 📌 Increases cognitive decline & dementia risk 🧠 📌 Alters heart structure, raising cardiac event risk ...
Feb 14, 2025•3 min
🚨 Air traffic controllers face severe fatigue due to the 2-2-1 shift system , causing sleep loss, cognitive impairment & safety risks. 🛑 FAA & NATCA now plan to replace it with a safer schedule to enhance aviation safety. ✈️ #Fatigue #AviationSafety #ATC The 2-2-1 shift system in air traffic control (ATC) compresses five shifts into four days , leading to severe fatigue due to counterclockwise rotation and insufficient rest periods . The FAA’s 2024 study found that this schedule causes...
Feb 13, 2025•2 min
The POPular PAUSE TAVI trial investigated whether continuing or interrupting oral anticoagulation during transcatheter aortic valve implantation (TAVI) affected clinical outcomes. The randomized, open-label, noninferiority study included 858 patients and assessed a composite primary outcome of cardiovascular death, stroke, myocardial infarction, major vascular complications, or major bleeding at 30 days . The trial found that continuation was not noninferior to interruption , with higher bleedin...
Feb 12, 2025•3 min
The six orthodox Indian schools of philosophy—Nyaya, Vaisheshika, Samkhya, Yoga, Mimamsa, and Vedanta—offer valuable insights into the mind-body connection, ethics, logic, and holistic well-being. Understanding these systems can benefit healthcare providers and patients in promoting mental, emotional, and physical health.
Feb 11, 2025•6 min•Season 1Ep. 6
The TCW Trial compared TAVI + FFR-guided PCI versus SAVR + CABG in patients with severe aortic stenosis and complex coronary artery disease . This multicenter, randomized controlled trial included 172 patients aged ≥70 years . At 1 year , the primary composite endpoint (death, MI, stroke, revascularization, valve reintervention, or major bleeding) was significantly lower in the TAVI + PCI group (4%) compared to SAVR + CABG (23%) , meeting both noninferiority and superiority criteria . The study ...
Feb 11, 2025•3 min
🚑 New studies on #OHCA: No significant survival benefit of intraosseous (IO) over IV access. IV remains the preferred route, with IO as backup. #EmergencyMedicine #CPR #CardiacArrest These 2 randomized clinical trials compared intraosseous (IO) vs. IV vascular access in out-of-hospital cardiac arrest (OHCA). The first study (Denmark) found no significant difference in return of spontaneous circulation (ROSC), 30-day survival, or neurological outcomes between IO and IV access. The second study (...
Feb 10, 2025•3 min
🚨 New study: Evolocumab shows strong CV benefits in older adults (≥75 yrs) with ASCVD! 📉 Lower LDL-C, reduced events (HR: 0.79, NNT: 19), & no major safety concerns . Time to rethink lipid guidelines for seniors? 🔬💙 #Cardiology #LipidLowering #Evolocumab
Feb 09, 2025•3 min
Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis . Traditional lipid-lowering therapies have minimal impact on Lp(a), necessitating novel treatments. Zerlasiran , a small-interfering RNA (siRNA) , significantly reduces Lp(a) (~85%) by inhibiting hepatic apolipoprotein(a) synthesis via subcutaneous injection . Muvalaplin , an oral small-molecule inhibitor , prevents Lp(a) particle formation, reducing levels by up...
Feb 08, 2025•3 min
1. NEJM Article (2024) : A 30-year study of 27,939 U.S. women found that high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) independently predicted cardiovascular risk. Higher levels of these biomarkers increased the risk of major cardiovascular events, emphasizing the need for early screening and prevention in women. 2. BrJSportsMed Article (2024) : A study of 13,018 women found that even 1–3 minutes/day of vigorous intermittent lifestyle physical activity (VILPA) significantly reduced c...
Feb 07, 2025•3 min
1. “Bioaccumulation of Microplastics in Decedent Human Brains” (Nature Medicine, 2024) This study confirms the presence of microplastics and nanoplastics (MNPs) in human brain tissue , particularly the frontal cortex. Researchers used pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) and electron microscopy to analyze postmortem samples, finding polyethylene (PE) as the dominant plastic type . Brain tissue exhibited significantly higher plastic concentrations than the liver or kidney, wi...
Feb 06, 2025•2 min
Kapila: Founder of Samkhya Philosophy Kapila (7th–6th century BCE) is regarded as the founder of the Samkhya school, one of the six orthodox systems of Hindu philosophy. Known for his rational and dualistic approach, he emphasized the distinction between Purusha (consciousness) and Prakriti (matter). His teachings are captured in the Samkhya Sutras and the Bhagavata Purana , where he elaborated on metaphysics, self-realization, and liberation from suffering. Kapila’s influence extends to Hinduis...
Feb 04, 2025•5 min•Season 1Ep. 5
Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT- HEART randomised controlled trial in Scotland Michelle C Williams, Ryan Wereski, Christopher Tuck, Philip D Adamson, Anoop S V Shah, Edwin J R van Beek, Giles Roditi, Colin Berry,Nicholas Boon, Marcus Flather, Steff Lewis, John Norrie, Adam D Timmis, Nicholas L Mills, Marc R Dweck, David E Newby, on behalf of theSCOT-HEART Investigators* Summary Background The Scottish Computed Tomograph...
Jan 31, 2025•11 min
Anaximander of Miletus (c. 610 – c. 546 BCE), a pre-Socratic philosopher and student of Thales, was a pioneer of cosmology, astronomy, and natural philosophy. He introduced the concept of the apeiron (infinite) as the origin of all things, developed early theories on evolution, and created one of the first world maps. His revolutionary ideas laid the groundwork for scientific thinking and inspired generations of philosophers and scientists.
Jan 28, 2025•4 min•Season 1Ep. 4
“The Protein Puzzle: Debunking Myths About Protein Deficiency in India” This episode explores and debunks the myth of protein deficiency in India, highlighting that most Indians meet their protein needs through balanced diets. It explains the Protein-to-Energy Ratio (PER) and how traditional food pairings like cereals and legumes enhance protein quality. Key insights include varying protein needs across age groups, the risks of overconsumption, and practical tips for improving dietary protein th...
Jan 25, 2025•9 min
Gargi Vachaknavi, an esteemed philosopher and Vedic scholar of ancient India, is celebrated as one of the earliest female intellectuals in recorded history. Known for her profound knowledge of Brahma Vidya, she engaged in rigorous philosophical debates, including a renowned discourse with sage Yajnavalkya on the nature of existence and the ultimate reality. Revered as a Brahmavadini, Gargi contributed significantly to the intellectual and spiritual traditions of Vedic India, inspiring generation...
Jan 21, 2025•3 min•Season 1Ep. 3
“Discover the legacy of Thales of Miletus, the first Greek philosopher and one of the Seven Sages. Known for proposing ‘all is water,’ pioneering geometry, and predicting a solar eclipse, he laid the foundation for science and rational inquiry. #Philosophy #Thales”
Jan 14, 2025•3 min•Season 1Ep. 2
Explore timeless wisdom with Dr. RR Baliga’s Philosophical Discourses! Dive into the teachings of Yajnavalkya: Vedic Sage and Philosopher and more, blending ancient philosophy with modern insights.
Jan 07, 2025•3 min•Season 1Ep. 1
COVID-19 in Patients with Heart Disease and Cancer Dr RR Baliga's 'Got Knowledge Doc' Podcasts for Physicians Coronaviruses and the Cardiovascular System Coronavirus Fulminant Myocarditis Case Review COVID-19 in Patients with Cardiovascular Disease and Cancer Sarju Ganatra, Sarah P. Hammond, Anju Nohria JACC: CardioOncology :Accessed online March 20, 2020 Not Medical Advice or Opinion...
Jun 12, 2024•10 min
