Low Progesterone and DHEA Drive Psoriasis
Jan 26, 2026•9 min
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Episode description
- Women with psoriasis consistently show lower progesterone and DHEA, two hormones that normally quiet inflammation, making flare-ups stronger and more frequent
- Estrogen dominance — where estrogen feels too strong relative to progesterone — heightens immune reactivity and explains why symptoms worsen before your period, after childbirth and during menopause
- Intracellular estrogen, not blood estrogen, drives inflammation in psoriatic skin, which is why your labs can look "normal" even when your symptoms intensify
- Long-term hormone replacement therapy increases psoriasis risk by overstimulating inflammatory pathways, especially in post-menopausal women whose hormones are already shifting
- You can ease flare patterns by supporting progesterone and DHEA, eliminating estrogen-mimicking triggers, avoiding seed oils, optimizing vitamin D and reducing stress-related hormonal strain
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