Hack Your Genetics for Optimal Brain Function, Gut Health and Detox with Kashif Khan - podcast episode cover

Hack Your Genetics for Optimal Brain Function, Gut Health and Detox with Kashif Khan

Mar 31, 20261 hr 3 minEp. 691
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Summary

Kashif Khan joins Dr. Jockers to explore functional genomics, revealing how understanding your genetic makeup impacts brain function, mood, and overall health. They discuss how specific genes influence dopamine and serotonin pathways, affecting stress management, productivity, and anxiety. The episode delves into personalized strategies for optimizing health and preventing burnout by leveraging genetic insights, covering topics from PTSD and gut health to hormonal balance and dietary choices.

Episode description

In this episode, Dr. Jockers dives into the world of functional genomics and how understanding your genetic makeup can impact brain function, mood, and overall health. Learn how specific genes influence dopamine and serotonin pathways, affecting everything from stress management to productivity.

Kashif Khan, a leading expert in genetic mind mapping, joins to discuss how genetics shape our behavior and emotional responses. He shares insights into how biohacking your genetics can help you optimize health and prevent burnout.

Discover how to turn genetic weaknesses, like low dopamine, into superpowers by adjusting your lifestyle and nutrition. Kashif also explains how this knowledge can help you make better decisions, manage stress, and improve overall wellness.

In This Episode:

00:00 Adrenaline Memory Imprint

04:24 Kashif Origin Story

05:58 Dopamine Burnout Genetics

09:07 Turning Kryptonite to Focus

10:12 Functional Genomics Framework

12:13 Military PTSD Gene Profile

15:27 Tools to Rewire the Response

19:36 Serotonin Detail and Anxiety

29:03 Vagus Nerve and Supplements

30:38 GABA Sleep and Cortisol

31:44 Simple Sleep Hacks

32:01 DNA Test Roadmap

33:00 Gut Genes Detox Story

35:38 Hormones Brain Link

38:27 Finding The Real Trigger

39:18 Prioritize Your Fixes

41:01 Live Q&A Support

41:57 MTHFR Explained

48:15 Universal Lifestyle Wins

51:07 Collagen Sponsor Break

53:13 Genes And Diet Fit

57:48 Personalized Nutrition Proof

59:09 Where To Follow Kashif

01:00:30 Aging Is Optional

01:02:01 Podcast Wrap Up

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"The key to optimizing your brain function lies in understanding how your genes interact with stress, sleep, and gut health."

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Transcript

Adrenaline Memory Imprint

Vivo Audio På Audi Originalservice och reparation. اشتركوا في القناة Boka Audi Originalservice 4 Plus. Your adrenaline pathway convinces your brain something's trying to kill me, something's trying to eat me. So I want to remember everything to avoid this mistake again. So it starts to imprint information. And when somebody has the dysregulated versions of the adrenaline genes, they not only imprint the intellectual information.

They also imprint the emotional information. Well, welcome back to the podcast. Great topic today. All about understanding your genetics, your DNA, and how that impacts your brain, how that impacts your mood. And how that impacts your level of productivity, your distractibility, your ability to, you know, basically to function and thrive in life. And so my guess is Kashif Khan from KashKhonofficial.com. He is a developer of DNA three sixty and the gut three sixty microbiome test.

And he's a best-selling author of The DNA Way. He's also a celebrity longevity coach, two-time TEDx speaker, and a pioneer in driving the functional approach to genomics. interpretation overlying environment, nutrition, lifestyle on the genetic blueprint to create personalized longevity plans. Again, he developed DNA 360. He's really a wealth of knowledge when it comes to understanding genomics and understanding how your DNA, your single nucleotide peptides, your SNPs, how they impact

your mood and your behavior and your overall health. And we're gonna go through that in detail. Most importantly, we're gonna help you find your superpower and understand some of these genetic pathways and how they impact your mood and behavior. So you guys are in for a treat here. If you're enjoying the podcast, take a moment, leave us a five-star review. Of course you can visit drjockers.com for great health articles and infographics on every major health topic.

So be sure to check that out. We've got a a a number of them on different genetic pathways. So be sure to check. those out as well, including MTHFR, which is really the most common one that's talked about, but also COMT. We've talked about a lot of different genetic pathways on drjockers.com. So you can check that out as well. And of course again, leave us a five star review.

Share it with somebody that you know and that you care about. And without further ado, let's go into this interview with Kashif Khan. If you're into good nutrition, you've probably purchased a protein bar or energy bar before. And there are some really big problems with these bars. Number one, the bars that taste good are typically not good for you. In fact, many protein bars have as much sugar as a candy bar. They have junk ingredients like artificial flavors and sweeteners.

and really low quality toxic protein like soy protein. Some have barely any protein and they should really be called carb bars because they are just so full of sugar. And they also have lots of scary additives you don't want in your body. Honestly, you're probably better off eating a candy bar than most mainstream health bars. The second big problem

Is that the bars that are better for you typically taste terrible. You know what I'm talking about. They're chalky, chewy. Many of them have a really strong artificial sweetener flavor that you just can't get out of your mouth. Plus, you can't be sure that the ingredients are even high quality. And that's why I'm so happy to have Paleo Valley superfood bars.

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like apple cinnamon, lemon meringue. They have red velvet and chocolate chip. These taste great. My kids love them. They're only organic ingredients, nothing artificial with no chemical sweeteners. Now you can go to paleovalley.com forward slash jockers and save 15%. Check out the superfood bars and all the other great paleo valley bars. Again, just go to paleovalley.com.

Kashif Origin Story

Forward slash jockers. That link will save you 15% on anything that you buy. Be sure to check out their super food bars. I love the lemon meringue and the red velvet. I think you'll like them as well. So check that out today. Well, here I am with Kashif Khan from Keshef Khan Official dot com. We're talking all about genetics.

mind mapping and finding your superpower. Kashif, how did you get into this? How did you get into functional genomics and really understanding How how genes impact our our behavior, our mood, really everything, every every element of our health. So it wasn't your typical path?

Right. Uh my my my path into it was actually from being ill myself. And I think a lot of great functional medicine stories have the same story. Somebody was struggling, couldn't get a solution, made their own solution and now wants the world to know.

And that that was sort of me. I had a lot of uh inflammatory issues like eczema, migraines, etc. I had autoimmunity, psoriasis, all sorts of stuff all at once. And it didn't add up. Like where did all this come from? I've never been sick and then all of a sudden everything, right? First time I ever needed medical intervention didn't give me what I wanted in terms of like the why behind what I was feeling. And so I started to dig and including genetics.

And that's where I learned that there seemed to be some answers, but even that wasn't so clear. And so I I dug in and kind of built my own interpretation around what these genes actually mean, including what you suggested around mine. The things that we talk about weren't really taught academically, so we had kind of had to build them.

Dopamine Burnout Genetics

Yeah. Yeah, absolutely. And so what did you learn about your own genetics? Like what did How as you were learning this, what did you figure out um that you were able to biohack in your own health? So if we start with the mind, the thing that hit me was w w you know, there's this belief that there's opinion, that there's right and wrong. And what I didn't know is that we each see the world through you a unique lens that our neurochemicals create.

And the genes determine how you process those neurochemicals, how you bind them, how you make them, how you clear them, the duration of the intensity of the moment. And so if what that was one of the things that actually made me very sick. There's a neurochemical called dopamine, which allows you to experience pleasure but also reward. So both sources of satisfaction ultimately.

And whether you're achieving pleasure or reward, your brain doesn't necessarily need both, but either will give it to you. And the way your body processes it, there's a bit of an anticipation as the dopamine gets released, and there's receptors in your brain that start to activate to bind that dopamine in order for you to have that euphoria in the moment.

Then there's breakdown and clearance and removal, which determines how long did that experience last. So there's proteins that get it out of the receptors. And if you look at my genetics, I have the lowest possible density of receptors. The DRD2 gene determines that. So my I have the worst version of the DRD2 gene. So the intensity level for me is way down here. And I have the best possible version of the clearance gene. So it's really fast.

So the way I experience the world is I can't get no satisfaction, right? It's like it's it's d it's felt way down here and it's gone way too fast. So at the time I got sick I didn't know I was living in burnout and my nervous system was completely overwhelmed and fried. Because my brain was so able to say yes and seek more because I just couldn't get satisfaction. But my body was no different than anybody else's and it couldn't keep up. Right. So what I perceived as a normal volume of stress.

What I perceived as a normal volume of work. I was running 10 companies. Wow. Right. Literally, I had 10 different companies that I was building and running. Two of them were doing it really well. Six were completely failing. And two of them were kind of junior and developing, right? But I didn't care. It's like warrior spirit. So that's when I learned that structure. And understanding what is actually required.

is the guardrails I need to not slowly kill myself, right? There's also supplements to upregulate certain uh pathways. There's also n nutrition and tease. And once you understand the lens you see through And how is it serving you or not serving you? Then you can decide how to intervene.

And now I don't have that burnout anymore, which was one of the major things that was sort of slowly chipping away at my biological age. Yeah. And that's because it takes a lot of stimuli to to produce the amount of dopamine you need to kind of feel like a win, right? To feel pleasure. And then you're clearing it out quickly. So it's like you get the once you get enough stimulus to get that win, it's gone r pretty quickly.

Turning Kryptonite to Focus

Yeah, and so you're just you're just working, working, working to get that next that next hit. It was always the what's next syndrome, right? Every shiny object was exciting. And that's why I was, why not do really well in one business instead of run 10 different ones? Because I couldn't say no to the opportunity. But what I've learned, and now here's what we teach people.

How do you take that kryptonite, that crippling kryptonite, and turn it into your superpower? Right. Right. And I've learned that there's equal satisfaction. in saying no to a distraction as there is in saying yes to an opportunity if it is aligned with the outcome. So what I've learned is the person like me who has the low dopamine brain really prioritizes by outcome. Show me the shiny object and I'll find my way to get there.

The person with the high dopamine brain, with the higher intensity and slower clearance, prioritizes by process. Give me an instruction and give me a deadline. I the outcome isn't such a big deal. I just need to know what to do and when to do it by. And if you understand the nuances of how your brain works and what drives you, you can start to structure things to get the outcome you want, as opposed to force pigeon calling yourself into a structure that doesn't work.

Functional Genomics Framework

Hmm. Yeah, that's good. Now what you mentioned the DRD two gene. Um what are some of the key ones? Obviously it's a dopamine receptor gene. What are some of the key genes you're looking at there as you're mapping out somebody's superpower? So the pathways you would look at and they'll talk about the genes are the dopamine pathways, so reward seeking, adrenaline, so let's call it emotional impact and emotional intelligence.

We look at serotonin, so mood regulation and propensity towards detail, so the the brain's ability to filter, and then brain drive neurotropic factors, so neuroplasticity.

And the you can take all these pieces and understand what each piece does. Then you can play this game of moving the pieces around and understanding what profile you've created, right? And it it it sounds complicated but once you learn the pieces it is so simple and elegant that you can really if I have someone's DNA I can describe their personality to a T without ever talking to them.

And it's like a tarot card reading, like, how did you know that? Right? Because the neurochemicals don't lie. So let me give you an example. There was a project we were working on. So why I know what I know. Is because once I healed myself and then my mom and my niece I built a research project. So I hired a couple of MDs, a couple of PhDs. They literally sat at my dining room table because I didn't even know why I was doing it.

And we started a map out which now is referred to as functional genomics. So taking genetics, just like medicine is diagnosed and prescribed. And functional medicine is why? Why did you get sick? Root cause. The same thing was happening with genetics. Genes were bucket into a very disease-centric, this is causing this, this is causing that, not the functional, how do these genes equal eventually disease? What do I do about it? Right. So that's the science we created: functional genomics.

And that only happened because I sat in front of people and clinically interacted with them to figure out not only the sick people, but also the healthy people. Why didn't you get sick? You have all the genes that point to all these problems. What did you do right?

Military PTSD Gene Profile

So we need to learn both, right? So I spent three years, 7,000 people, one by one by one, understanding their profiles and what drove them to the outcomes. Right now we can reverse engineer and teach that. So in that time, one of the projects we did was with the US military. There's a group called the Liminal Collective that was contracted by the the Navy SEALs to just optimize them, biohack them, right?

And one thing they were stuck on was we don't understand trauma. We don't understand PTSD. It doesn't make sense. Same training, same everything. Why different variable outcome? As we said, of course, genetically they're not the same person. How can you expect the same outcome? So we were contracted to do this work, and here's what I showed them. Is that when you deploy someone into active combat and they're in that intense moment of stimulus, it's an adrenaline run.

Right, pulling the trigger, seeing the bomb going off the adrenaline, pumping the chest, we know that feeling, right? And the genetics of adrenaline are driven by the adra to B pathway, which determines the regulation or volume of adrenaline causing the upregulation in your biology. So adrenaline makes you bigger, stronger, faster, right? Superhuman temporarily to give you what you need in that moment. But adrenaline does a second thing. Because that moment is so impactful.

And because your body doesn't know that's it's the year twenty twenty six, your body still thinks you're a cave person. Your adrenaline pathway convinces your brain something's trying to kill me, something's trying to eat me. So I want to remember everything to avoid this mistake again. So it starts to imprint information.

And when somebody has the dysregulated versions of the adrenaline genes, they not only imprint the intellectual information, they also imprint the emotional information. So some people are genetically wired to remember what things feel like and some people aren't. And so they actually imprint. And now when they're reminded of that sound, smell, face, they feel it like it's happening again, a continuation, right?

But that was half of the story because when I looked at the genomic profile of these soldiers, the ones that only had this still didn't really experience trauma. Yes, there was a recall, but it wasn't dehabilitating. The ones for whom it was dehabilitating, there's a second layer. This is what I mean by functional. The the sit not this gene is this, this gene, but putting the pathways together into a profile, right? Yeah. The other half was BDNF, brain derived neurotropic factor.

the lack of neuroplasticity because they had a suboptimal version of this gene. So neuroplasticity is whenever I'm learning something, accepting something, believing something, I need new neurons in my brain to process that new information. to accept and give myself the physical real estate to to know that information. Right. There's like a unique unique place in your brain where you know whatever you know.

So, when you have slow neuroplasticity because of a slow version of this gene, that same exact experience, you may experience what we call a shell shock. Which is this is a big deal. Slowly, slowly processing as opposed to moving on, right? So now when we saw that combination of I have the adrenaline dysregulation, so I remember what things feel like.

Tools to Rewire the Response

But I also have the BDNF dysregulation, so I give that thing more weight and meaning than it deserves because it was it took longer for me to process. So it was a shell shock. That combination was a soldier that says, I can't do this anymore. But that was the one that when they were reminded they're just completely nervous system broken, can't do it anymore. So now what is the answer? Is it that this person should never have been deployed?

That's one potential answer. You are wired to be the researcher, the scientist, because you think deep. You have emotional intelligence. You work with purpose. That was your wiring, your your superpower, right? Or we know the exact tools that upregulate your BDNF and slow the adrenaline genetics down. So you have two choices. You've now identified the profile. Step one, who am I?

Right. I am this unique profile. This is how I see the world. And this is how I'm going to react. Now I have to decide: is this serving me for my purpose? Great. Or is it identifying my purpose? Let me go do that. Or is it I don't have a choice. I have to do this regardless. And I'm not designed for it. Now let me add the nutrients that upregulate those genes to give me what I needed.

That's how to use genetics functionally, as opposed to this gene means you have 80% of Alzheimer's good luck, right? Yeah. I just want to take a moment to interrupt this podcast to tell you about one of my favorite podcasts I listen to. It's called the Dr. Josh Axe Show, hosted by my good friend Dr. Josh Axe. Every week he shares how to balance your hormones. Restore your gut, boost your energy, and slow aging.

without relying on harsh medications or quick fixes. He shares both ancient biblical practices, and the latest breakthroughs in nutrition, herbal remedies, and lifestyle medicine. And he sits down with world renowned experts to have real Unfiltered conversations you won't hear anywhere else. So if you're ready to take control of your health, renew your energy, and transform your mind, body, and spirit, tune into the Dr. Josh Axe show every Monday and Thursday wherever you get your

Right, absolutely. Now, let me uh just see if I understood what you were saying there as far as these people that were more prone to PTSD, they had. higher firing, heightened amount of adrenaline response, right? So more adrenaline than kind of the average person. And then also they were low in B DNF, right? So they weren't able to kind of get this positive neuroplastic change.

that BDNF provides where it's like miracle growth for the for the neurons. And so and they couldn't clear the adrenaline as well. Is that is that correct? Exactly. They also you're exactly right. They also took Lometer Clear, which by the way, is the exact same comp gene that clears the dopamine. Right. Okay. So that's the same quote patrick. Exactly. So they're stuck in the moment for longer and they're also recalling more information because they were in the moment for longer.

Right. So that total weight creates the burden of what looks like PTSD. So do they have a cognitive challenge or are they just genetically wired for a different purpose and they were given the wrong job? That's interesting. We'll see like the best coaches, the best guides, the best healers, the emotional intelligence part is they're wired that way.

So the when sometimes you happen to land in the right context and you unlock your superpower. So that's the what we're trying to figure out. Who am I? What's the purpose? They they have more empathy, right? Where they're they're actually feeling the pain of somebody that's that they're with versus somebody that has less of that. Yes, exactly. And we'll I actually do work on coaching like CEOs, for example. So we'll go into a corporation and we'll help them rebuild their C suite.

The COO, the CO, the CFO, because they're assuming what they're good at or what they want to do, but we can actually tell them from the wiring who should be doing what job, what their capacity is. and we'll rebuild this management team and all of a sudden they start aligning and working together and there's no more conflict, no more friction because they know their superpower and they know what was blocking them or leading them.

We'll do this on sports teams too. I I work with NHL, NBA, where like why is there friction between players, right? Why is there this guy doesn't have the clutch.

Serotonin Detail and Anxiety

He can't perform under pressure, right? Why is it that this guy doesn't listen and doesn't follow the rules? And so we'll actually teach them how their brain perceives even instruction. And it helps them do a better job as a team and the glue comes back to the city. And so some of the key genes you mentioned, the COM T gene, which helps clear out dopamine, helps clear out

uh adrenaline. It plays a role with like estrogen metabolism. I know a number of things like that as well. You mentioned the DRD two, so that so dopamine genetics. I'm sure you're looking at like serotonin. Probably endorphins, right? A lot of different things like that, GABA. Serotonin, I would tell you, it doesn't matter who we're dealing with, whether it's a NHL hockey player or whether it's stay-at-home mom or dad, almost everybody, we have to work on nervous system first.

And most of them don't even know that, right? Most of them come saying, I have pain, I have, you know, uh breast cancer, I have whatever. And when we go into their profile, we also tell them you're also stuck in fight or flight.

And the genetics of that are some people like me don't know. You're wired to push through and burn yourself out, which will crush your nervous system. And there's some people genetically that are wired to feel it viscerally, like everything is causing anxiety. So there's both sides of the scale, right? Um and I would tell you that if you look at general population genetics.

The take 10,000 people, you might find that between 5 to 10%, we don't know the exact number, but it's a between 5 to 10% of people have dysregulated serotonin genes. Right. So 90% are doing a good job. And I'm gonna explain what that means in terms of outcome and profile, but in terms of the impact. Then when I do a genetic masterclass, which I do often, which is like

100 people, 200 people in a room, everybody has their DNA in their hand and I'm walking through what the genes mean and everyone's being taught given that the genes don't change. It's one of the few things where it's useful for a person to learn because they can always use the two, right?

So we do these classes. When I do a generic master class, 200 people, most of them are struggling with something. So they're looking for an answer. Right? It's like I did everything. I did everything right. Why didn't it work? In that context, room full of people where people are struggling, it's usually when I ask about the serotonin genes, around 60 to 70% will raise their hand.

Saying that, yeah, I had the bad version of the gene. So general population, it's five to ten percent. Take a room full of people that are stuck with their health healthcare issues, 70% will raise their hand. So why? And this is consistent, right? Because I do these classes regularly. There's consistently 60 to 70% will raise their hand because the nervous system being fried is.

Locking you into an actual context called fight or flight, which is not just woo-woo, it's an actual shift in biological priorities. The energy is move towards the your immune system is shut off, your gut is suppressed, your inflammation is raised to a very high level. It's very easy to get a chronic disease. And recovery is shut off. So all the good stuff you're doing, if the terrain isn't ready,

How well is it gonna work? The ROI isn't there. And then you blame the thing. The stem cell didn't work, the supplements didn't work, or maybe the terrain just wasn't ready. Right. So why does this all matter? Serotonin we know of it as and the genes involved are five HTTLPR. which determines the length of the receptor. So how much do you experience? How much do you bind? And then TPH, which drives the tryptophan response, which is a precursor to serotonin. So how much do I make?

How much do I make and how much do I bind? That's the total story. There's also clearance, but these two are the most important, right? We know serotonin is a mood regulating chemical. It is does my mood look appropriate for whatever I just experienced? Or does it appear to be more bipolar, more up and down, right? The mechanism that drives that, and this is what's missing from the conversation, is serotonin allows your brain to prioritize information.

So as we're sitting here chatting, some people are attentively listening and learning. And some people are like, what are those books behind Dr. Joker's heads? And there's reading the title with some of them like, hey, is there's a door behind why is that door up in the sky? It should be on the ground. And they just can't pay attention, right?

And it that's what it feels like, can't pay attention, but what really is happening, they're paying attention to more than their brain needs to pay attention to, because their brain can't prioritize. This is meant to be a superpower. Now, when your brain can prioritize and you see the world at an elevated level of detail, everything is irritating, everything is frustrating, everything is annoying, everyone is disappointing.

And it creates what if I were to give it a archetype, it's like the helicopter mob. Right. The helicopter, like every little thing matters. No, the card has to be like this and no nuts on this thing. And did everyone check mark and check themselves in versus the other more loose mom was like, no big deal. Let's just get this done.

Right. So when you truly see the world at 130% of what's actually going on and 90% of the world or night somewhere between 90 and 95% is not seeing the world that way, imagine the friction. The constant you said it was gonna happen like this, but then it happened like that. That's not what we agreed to. And they're like, it got done, who cares? Right? Right. We cop often see again someone that's stuck is wired this way. And they're living in a state that we call high functioning anxiety.

Which is not just the anxiety of like, I don't want to get out of bed, leave me alone. It's the anxiety of like there's a fire in my belly, need to get it done. You don't know what you're doing, give it to me. I'm gonna take care of it. I'm gonna fix it. Right. Seeking perfection. Never resting. Resting is a source of guilt.

Right, waking up in the middle of the night like what was I supposed to be stressed out about? Oh that okay, now I feel normal again. Right? And then not sleeping the rest of the night. So that high functioning drive, which again was meant to be a superpower when it was engaged acutely and temporarily in a some sort of calamity.

The cave person, everybody had the day looks the same every day. And once in a while, bad weather, hey everybody, I see this, turn around. Once in a while, bush rustling, hey everybody, animal over there, let's go this way. And you're the first to see it. was not meant to be engaged every day all the time, which is now the amount of stimulus we experience, right?

This crushes the nervous system. It leads to cortisol addiction. It leads to like the high stress of cortisol. It feels more normal than rest and recovery. And when you bundle this up, no surprise, 60, 70% of the people that are in our programs that are stuck, stuck, stuck, are wired this way. Right. So work to be done, first of all, like directly addressing it.

And then also unwinding the habits and even just the the knowledge of knowing how somebody is wired and then coming back into the room with the other people and finally seeing, oh, I get it now. They don't even see what I'm seeing. It's not about they're lazy or aloof or don't care. They're just meeting me where they're at and the volume of detail they see. So it's finding that gap, right? And knowing that this is a superpower that's not meant to be engaged all the time.

only in a time of calamity helps calm things down. But there's a lot of supplements and nutrients and vagus nerve stimulation and things that can be done also to help mitigate it all, right? Well I just want to interrupt this podcast for a very important public service announcement. One of the most dangerous things you may be doing for your health is cooking. a healthy meal at home. I know that sounds crazy, but here's what the science says.

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Vagus Nerve and Supplements

C-H-E-F-S foundry.com forward slash jockers before this offer disappears. Your body will thank you, but so will your family. Yeah, I think that's so important. Those personality types and people that are struggling with with that. Magnesium, also are you seeing magnesium help a lot of these uh personality types? For sure. You have magnesium before sleep, even in the morning. Um, everybody needs more. You know, it's that's a very yeah. Uh so you for sure.

Uh we find that there's definitely the vagus nerve like you were talking about, just stimulating it. There's devices like the Hulas, the polo neuro. They're great for vagal tone, right? Pulsetto. We've seen all these devices, right? Even something as simple as breath work and meditation. You know, the the I would say the the fastest way to rinse the inflammation of cortisol off of your cells is just meditation. It's the opposite, right? It's just sitting there and disconnecting and

And giving your mind rest and recovery, giving it to the locking yourself in a room and just breathing, right? If somebody were just sit there and for a minute, First of all, you would learn how minute how long a minute can actually be, right? You may have forgotten. And second, what that does for your nervous systems, we just don't do it. We don't rest.

Uh and so supplement 5 HTP. 5 HTP is the fuel that gives you the tryptophan to feed into serotonin. Ltheanine, GABA, calm those nerves. Get your brain into sort of a more theta state as opposed to an alpha bit on state, right?

GABA Sleep and Cortisol

So the the the good news is the solutions aren't complicated. Right, they're they're fairly simple. It's just identifying the right problem to solve using it. Yeah, it's really good. Now how about GABA? You mentioned that uh obviously it's a calming neurotransmitter. Are you seeing certain genet certain genes associated with like low GABA signaling? So not necessarily the signaling, but then the need for more, especially when it comes to the dopamine property. So people that are wired like me.

Uh one of the best tools is Gab Up. Right. Yeah. You'll find that you start using GABA, all of a sudden I'm sleeping. You didn't have a sleep problem. You had a fight or flight problem. You had a high cortisol problem. Right. And GABA 30 minutes before sleep and all of a sudden your brain stays in theta and isn't interrupted. You know, when people say I can't sleep.

It's not that general. It's like can't fall asleep or can't stay asleep. Those are two very different problems. Many people fall asleep. But then they wake up at two or three AM and the quality's not the same anymore. They get out of their deep, their body's trying to get into REM and it's just not working, right? And if you went into sleep with high cortisol and your brain's confused the circadian rhythm

Simple Sleep Hacks

still thinks you're it's nap time and not sleep time, right? And and there's genes around that too, around circadian rhythm genetics, where we can be more precise.

DNA Test Roadmap

Uh, then yeah, GABA is a a great solution. Another very simple one, just temperature dysregulation. You know, if somebody has dopamine issues, just getting some ice cold water on your face before going to sleep, upregulating. You don't even need a full cold plunge, just your your face, your forehead, right?

So like I said, the solutions are simple and elegant, just knowing what that's good. And so they can get the DNA three sixty test, which actually maps all this out. You actually have like a whole section based on, you know, brain and neurotransmitters. Yeah, and it's I would say I would start there, neurochemicals.

Tip here's the process we would typically walk people. So suppose uh there's the test, which is reporting, then there's the classes I teach. So suppose suppose somebody was in a class with me. The process we would go through is to first work on neurotransmitters and neurochemicals to work on the nervous system. And get the terrain in a state where it's ready to repair. Then we would work on the genetics of the gut.

Because that's another terrain consideration. It's very difficult today to not have dysbiosis, leaky gut, which is again directly connected to brain health.

Gut Genes Detox Story

You know, for every one signal the brain is sending down to the gut, the gut is sending eight signals back is overwhelmingly more influential to the state of your brain than the brain is to the gut, right? So the be the the second thing we work on is gut health. There's genes that tell us let me give you an example.

Um, so we're all familiar with glutathione, right? Glutathione is this master antioxidant the body uses to sort of clear, neutralize toxins. There are genes that tell your body how to utilize glutathione for different threats. For example, sometimes you breathe the toxin. Sometimes you put a toxin on your skin. Sometimes you eat a toxin. So there's a gene called GSTM1 that is responsible for glutathione activity in your gut.

So whatever you eat, the toxins, chemicals, plastics, mold, pesticides that come along come along with it, the detox response, which was supposed to immediately happen right there and then, this gene GSTM1, I am missing. So when you open up my human instruction manual, it's not about a version or variant. There's a phenomenon called a copy number variation as opposed to like a SNP or a variant in a gene, a version of a gene. Copy number variation means did you even get the gene?

A variation in the number of copies. And for me, my answer happens to be zero. It doesn't exist for me. So this instruction to attack, neutralize, or remove toxins in the gut for me doesn't happen. So one of the reasons I was so sick. is me and my business partner used to eat out almost daily because we were entertaining clients and we thought we were doing a good job eating this Mediterranean food right quite regularly, right? Uh Lebanese, Mediterranean, Greek food, that type of stuff.

What I didn't know was in Canada where I live that there's chemicals used to dry grains and then reconstitute grains because we have long winters and we need to store stuff. And those chemicals are tested as safe by the FDA in Health Canada. People seem to not react to them, but they weren't tested on my genetic profile, where I have zero capacity to detoxify it.

And so I didn't know that the eczema I had wasn't a separate skin issue. The migraines and brain fog that I had wasn't a brain issue. It was severe neural inflammation from leaky gut that led to leaky brain. Because I was lacking this genetic instruction. And so the second place we go is gut, because again, a systemic terrain consideration, nervous system and gut are the foundations for is the terrain ready for the other healing?

Hormones Brain Link

Then we get into sleep. Then we get into the detox pathways. Then we start looking at disease markers like do we see cardiovascular issues in your your future kidney issues? And let's address those. Then we get into hormones, the genetics of hormones. And none of these are independent of each other. In as much as we're hormones is the last step, hormones influence the mic.

Right. Why do we see that eighty percent of dementia cases are in women? Why is it so much more in women? Because you get into menopause as a drop in estrogens, it's protective hormones, but also The estrogen metabolic pathway, it doesn't end at estrogen. You make estrogen metabolize. Two hydroxyestrogen, four hydroxyestrogen, sixteen hydroxyestrogen, and two out of three of those are inflammatory in nature.

And some women genetically are overwhelmingly produced too producing too much estrogen. They're estrogen dominant. We can predict it with DNA. And they're filling a bucket of one of the toxic metabolites. Now take that into menopause and the constant trickle of now my estrogens are drop, but I'm still making the toxic version, causing inflammation to my cardiovascular tissue, my brain, et cetera. Then all of the things that equal bad brain health are amplified. By this internal toxin.

Right. And so I would say here's a flow, but there's these are not standalone independent. They all interact, they're all redundant. Right. So Understanding how they overlay interact gives you a more wholesome answer. I'm a huge advocate of regular strength training to build muscle. In fact, studies show that muscle loss is a significant risk factor for developing chronic disease and dying early. This is why muscle is called the organ of longevity.

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Finding The Real Trigger

The app guides you step by step. It's like having a personal trainer that never takes a day off right by your side. Stop working out in the past. Visit amp.ai and get your home gym professionally installed into your home. Amp.ai. AI designed for you to move and build muscle. Yeah, that's interesting. And how did you isolate? the chemical to what was being sprayed on the wheat.

to help that help it help it have, I guess, better shelf life or or be able to dry better, as opposed to maybe pesticides or herbicides that were on chickpeas and the hummus that you were eating or, you know, anything else. So you know what? It actually was the first time. Because chickpeas, people don't realize that, but chickpeas are one of the highest sprayed crops out there. Yes, that's literally what it was. It was the chickpea.

Prioritize Your Fixes

So I was eating hummus three to four days a week. Yeah. My nutritionist friend told me that's one of the best things you can do, right? But my nutritionist friend didn't it was it not their fault, they weren't aware of the context. So um So that is what it was. So it's it wasn't just the drying agent, but it was all the other chemicals too, right? Yeah. So what what this did was I learned what my priorities are. Right. There's so many things you could focus on. Everybody can't do everything.

Yeah. And that's another challenge. Once you go down this rabbit hole of even being on this incredible summit that you put together with all these amazing experts, right? There's so much wonderful information and people are going to learn by participating here. Where do you start? Right. What is the priority? So that's all I'm saying is I now know there's other systems where I'm doing really well. So for example, cellular regeneration.

You know, senescence all being cells being the apoptosis of death and removal and replenishing of new cells. I do this job a little more advanced than other people. So I don't necessarily need to focus on the NM NADs and NMNs and NMRs and all the cellular health stuff because my body's doing exceptionally well there already. So how do I isolate and focus on the right stuff for me? Right. That's kind of what I'm saying is like now to your point.

Did I know my God doesn't detox, so I need to understand all of the additives and chemicals and all the foods and and what is a threat, not just the fancy picture of the packaging, but how did it get there? Right. So that is a major priority for me. And, you know, I literally just went straight carnivore for a few weeks.

And voila, I don't have a disease called eczema, which a doctor said I have. Right? Where did it go? It was a it was the outcome of inflammation. It was like a check engine light. My body was saying, dig deeper, something's going on, right?

Live Q&A Support

So this is how I would use this information and it just helping prioritize of all this great stuff you could be doing. What's gonna give you this bigger biggest ROI? And for some of you, there's things you might be doing that you don't even need to do because your body's already doing a good job with that. So that's the great advantage of understanding this. And you're teaching courses on how people can understand their superpower. Is that right?

Yeah, in fact, I think um in in this context, right, just because there's so much information here. Um I I think we talked about hosting like a live QA webinar type thing, which we're gonna do, right? So if anyone has direct questions about their own unique circumstance or what this like ALS Parkins is, doesn't matter what it is.

We're gonna host a live webinar, live QA. It's it we don't get to do this often. I love doing it because I love helping people get their answers. So we'll talk about that later. You show up and because it's it's very hard to just get a report.

MTHFR Explained

And try and interpret it. You know, I make it sound easy because I've done it a thousand times, well, many thousands of times, right? Uh, but there is interpretation, there's nuances, which it means how do we consider your context, your environment, your lifestyle, your age, all these things matter.

So we'll host that QA just to help guide. Yeah, that's great. Now, a lot of people have heard of the MTHFR gene. That's probably the most well-studied gene. Can you break that down in the importance of that and kind of understanding all the dynamics here? Yeah. So another example of

Talk to five different people and they'll tell you five different things about what this gene means. But it means all of those five things. There's not none of them are not true. And it comes down to interpretation. What problem are you trying to solve? And how is the gene related? Not what does the gene do? We look at it the wrong way. It's not prescriptive. It should be a tool to go back to, right? So first of all, MTHFR is the central starring character of a system called methylation.

And where we get things wrong, remember our most of our genetic research comes from pharma research. Which the intention is let me isolate a gene so I can make a drug. That's the path, right? When really it should be the opposite. Let me combine all these genes to see more of like a chain and how does this link influence the rest of the chain? As opposed to just a link. Right? That's the pharma way of thinking. We want to be more functional.

So if you look at MTHFR, it's so it is surrounded by other genes called SHMT1, FUT2. MTR, MTR, or there's all these other genes that kind of like baton pass. Job gets done by a gene, gets passed on to the next gene, and that gene adds and contributes more work and it keeps going down the path. And now the job is fully done. So if you only look at one job, you don't really understand the full flow, right? So now what is methylation in simple terms?

I would say the easiest way to describe it is anti inflammatory response. It's the the thing you're relying on to shut the fire of inflammation off, which is why it's tied to things like autism and neural inflammation and women's health issues, because whatever else is going on. The inflammatory outcome might linger and this burden becomes bigger because of lack of methylation. But it does three other things. It is also a system of conversion.

So if you eat a banana and you think you're getting some potassium or some beta carotene from your carrots, how did that actually get into your cell? They need to be converted into bioavailable forms and that is a process of methylation. So they get methylated and turned into something your body can use. It is also a

Clearance meth uh conversion. So things like metals and plastics that are not so water soluble. Your detox pathway is assuming that it can make things water soluble so that you can pee them out and sweat them out and poop them out. But we now live in a reality with which our body didn't know we're gonna have to deal with heavy metals and plastics and other toxins that we weren't supposed to, right?

And so there's some things that are harder to remove and they need to also get methylated, broken down, converted so that they can be removed. So that's another, this is also why it's tied to things like autism because of the heavy metal injury to the brain for things like vaccinations, for example, right? The third thing that it does, and this is perhaps the biggest thing that is the biggest impact, that is the also the least spoken of thing, methylation is the regulation of gene expression.

So you walk into a room and the context changes. Suppose you smell some chemicals. Your detox gene should start working better temporarily. Suppose you eat a meal, your metabolic gene should turn on. Right. So your body is supposed to turn up and down the volume of these genes to give you exactly what you need in the moment for what you're experiencing. So your body will shift priorities. That is a question of gene expression.

temporarily turn on the volume because I'm doing something and I need more of something. Methylation is what turns the dials of the volume. So if you're not methylating well, the time it takes you to adapt is longer. And so the negative outcome of the things that are bad for you are more exponentially worse.

Right. And so some people that don't methylate well are more sensitive. They take longer to recover. They smell a chemical and don't feel so good. They go golfing and breathe these pesticides and the next day they're exhausted because the things they needed to cope didn't turn on in time. Right. So this is a very important system. It's and you can't name another system from hormones to neurochemics and metabolism that doesn't touch. It affects everything, right?

So we talk about MTHFR as this isolated singular gene that is such an oversimplified way to look at it, but also the research and information we have came from the desire to oversimplify to make a pill.

Yeah. Instead of empowering us with the full picture, which is so easy to do, I know I I make it sound like a it's a lot, but learn it once and you'll see it's actually Yeah, it's a really good breakdown. And uh yeah, a lot of people have talked about MT M T H F R and You know, here's the great thing is, you know, you all of us have DNA SNPs that are, you know, different variants that are not the highest form of that particular enzyme.

But we were all built to have a certain superpower, right? And that's kind of what what you what you like to explain. It's really about knowing your unique uh biochemistry, right? And understanding that and understanding kind of where your strengths and weaknesses. Right. And and being able to kind of balance out weaknesses and and magnify strengths. You know, if if something arrives at my house on Amazon. I read the instruction manual.

A microwave, right? I'll read the instruction manual before I turn it on. Something as complex as the human body, we don't even bother reading the instruction manual to understand how it's wired. You know, this is why fun does not only genetics, but functional testing in general, gut microbiome, neurochemicals. you know, toxin testing, uh, Dutch test, hormone testing, like where are you at?

Right. And and so and what you've put here together today and learning how the body actually works with all these experts. And no the knowledge will guide you and direct you. You don't need to wait for something to break and then call the doctor and say, please fix it. Right? You can with information empower and prevent.

You can understand where you can read the instruction manuals and understand how your body works and know what the right problem to solve is as opposed to this free-for-all listen to a new podcast every week and just do everything. And some of those things might even hurt you. And I can actually talk about

Universal Lifestyle Wins

The genetics of the thing that absolutely we believe to be true is good can actually hurt somebody, right? Yeah. Yeah. Absolutely. Now, last question, like what what are the top, let's say, three to five things that you see kind of cross the board benefit pretty much all genetic types, like as far as lifestyle things? Uh

So if we're going through like a class of a bunch of people, the one thing that comes up from every for everybody is EMF mitigation. Doesn't matter where you're at, your genetics, we are inundated, it's ubiquitous, it's everywhere. And if you don't have like can't sleep at night, sore, can't detoxify, can't recover, yeah, you're also bombarded with EMF all the time.

Right. So that's one area where we tell people, doesn't matter what your genetics are, you need a plan to mitigate, to neutralize, turning the Wi-Fi off, some EMF mitigating device of sorts, right? The other area where we say everybody has to just do the job is your toxic burden. You know, today your indoor air quality is five times worse the outdoor air quality pollution, right? And I'm sure it's gonna come up in all these great conversations you're having, how that affects the brain.

You know, it's it's it's it's said that it's one of the leading drivers of Alzheimer's today is in inhalation. Just inhalation of toxins that are causing neural inflammation that we don't even see or feel or taste is just happening, right? So purging your environment of everything that is an endocrine disruptor, everything that is a fragrance, everything that is synthetic, because think about not the one simple thing, but the total accumulation of all of it.

That's the burden. So your toxic burden. I would say the third thing is your the single greatest contributor. To the expression of negative disease causing genes is negative emotion. Stress, anxiety, trauma, negative thoughts, toxic people. is the number one way to turn on a gene that causes cancer, causes a disease, right? The number one way to shut them off and engage longevity genes is positive emotion.

And I'm pointing this out because culturally, rest, recovery, joy, pleasure, love to us is like a source of guilt. It's like I need to be on. I need to be working. I need to be active. I should not be laughing and joking. That is like I'm wasting time. Right. It is therapy. It is necessary. You can't make your hormones. You oxytocin is a base love, the love hormone is a baseline hormone for everything else. Right. So if you're not if you've lost the way of how humans are supposed to live.

And if you don't have pleasure, joy, love as a daily dose of therapy, it'll make you sick.

Collagen Sponsor Break

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Genes And Diet Fit

Yeah, it's a great rundown right there. You know, so gratitude and uh like you said, laughter. I mean laughter is our greatest medicine. So uh so make sure we're engaging in things like that. It's a really, really great rundown as far as that goes. Now. Do you see any of these genes impact? like the foods, the kinds of foods that you should eat. For example, are there are you seeing certain genetics that would s would would say that this person

Uh would do better on a more carnivorous type diet, low fiber, right? Lower fiber diet versus somebody that may do better on a higher fiber diet. Definitely. I would tell you that any sort of elimination diet, someone's gonna feel good in the first few weeks. Yeah. Right. But if you eliminate ultra processed food and toxins, yeah, for sure. Yeah. Right. Keep it clean, you're gonna feel good. Now the sustainability of that choice is what matters, right?

Is it something that is a w twice a year reset? Or is it a permanent choice? So the genetics of fat metabolism, the actual enzymes you need to be a carnivore or a keto, for example, it is variable. So some people cannot sustain keto for a long time. They have to take a break.

the the thing that we think that sugar causes diabetes in some people genetically there's a phenomenon called epistasis where fat will cause diabetes. The opposite of what we believe. Right? We actually tell some people do you your metabolic dysfunction is more from fat than sugar. So that's one The enzymes for starch. There's some people. I was doing some work with the US female Olympic team, but this is a few years ago.

And their question was, why is it that and training time these these particular four or five girls out of the hundred do really, really well. But when it comes to competition, they do horrible. And they thought it was up here, neurochemical, stress clutch, right? And when I looked at their neurochemicals and stress, it there wasn't a problem there. So I dug deeper and I found that all of those girls that they pointed their finger at

were really, really good at metabolizing starch and carbohydrates and turning them into fuel. And their the TCF7L2 gene that drives the insulin response was also incredible. So they were kind of wired to thrive off carb. When they went from practice to competition, they went from their local private decision making to a team that made this meal plan for everyone and put everyone on this low-carb cutting meal plan.

And it was literally the lack of carbs that made them fall apart. So this thing that we think universal global statement, low carb, doesn't work for some people, right? But then there are some people that that's the exact thing they need to do to prevent Alzheimer's, to prevent demonentia because like they are metabolically a disaster if they were to go up a tiny amount of carbs, right? So plant-based, how many people

That start eating vegan a year later, hormones dysregulated, mood is off, muscle is falling off their body, everything is falling apart. But they don't blame the vegan diet because as an elimination diet, it felt so good in the first two weeks. Right. Yeah. There are specific enzymes for how you break down plant proteins and the ability to actually get the building blocks and the amino acids out of them. Some people don't do a good job there.

There's specific enzymes for how you break down leafy greens, kale, spinach, broccoli, cruciferous plants, and some people don't do good there. And some of those foods are oxalate rich, will break your gut down. This is why you have that argument over do oxalates matter or not, because some people genetically plow through those foods really well and don't have the exposure.

And some people can't break those foods down. So the oxalate exposure is much greater, will hurt them, right? So yeah, if you give me your DNA, I'll say here's your meal plan, right? And it's genetically designed, uh, based on whatever your ancestors did, you're gonna eat that way. Mm. Yeah. So really interesting. So certain genes are gonna impact that. You know, I always say tell people there's like a fiber

It's like a fiber bell curve, right? There's some people on the far right that do well on a very, very high fiber diet. And they tend to be the ones that are always telling everybody you should all be on a plant-based diet. And then there's people that do very poorly on fiber and they need more of a very low fiber, if not like a full carnivore diet.

And uh they're often telling everybody they need to be on that diet. But most of us are somewhere in the middle there um of that bell curve, right? And kind of figuring out like where your fiber threshold is for that where you feel good, where your gut feels good, you move your bowels well, you have, you know, less gas bloating, reflux, different issues like that, kind of figuring that out.

Optimizing your protein to start, figuring out your fiber threshold and then kind of filling in the gaps with some some healthy fats up to your threshold as well. Cause like you mentioned, there's a lot of people that they can't handle a lot of calories in a meal.

Personalized Nutrition Proof

There's other people that can handle l high amounts of calories, high amounts of fat, like I can. I can eat I can easily eat fifteen hundred calories, you know, if not two thousand calories in a meal and feel great. Uh my wife on the other hand, five, six hundred calories is about it, you know, eight hundred calories maybe at the max, right? And that's that's good for her in a meal. You literally describe me to a tea?

And it's just part of my solution, which was I'd I used to like I said, Mediterranean diet, I was eating a lot of salads, a lot of raw plants, and I could not tolerate the fiber. I could not tolerate the plants. And like you said, I had reflux. Yeah. And a horrible reflux issue, bloating and gassy, brain fog all the time, right? Pain, inflammation. Because when you do it every day over time, the accumulation is going to hurt you, right?

And I could not sustain that my the training I was doing. And while my trainer was telling me to eat in terms of calorie volume, I also couldn't tolerate that. So I'm literally the opposite of you. I'm your wife. Right. So I that one change in terms of diet completely resolves so many things. Uh, but you're right that many, many people are somewhere in the middle. And where this matters the most is for the person that's stuck. It's like nothing works.

Right. When nothing works, you're probably on some extreme genetically, which is the middle is not the right answer. And that's the person that actually needs the most help, like me. I needed the most help. I was stuck. The middle does not work for me.

Where To Follow Kashif

Yep. Yeah. And that's where you gotta figure out. the the right diet for you. You got to personalize your diet. So that's that's key there. And that's really the best diet is a personalized diet. And ultimately the best supplement plan, the best lifestyle plan is a personalized plan. And that's, you know, what you're helping people with. And people can find out more information on your on your website as well. Uh it's cash con.

His last name spelled K-H-A-N official dot com. So cashconofficial.com. When people go to your website, What should they look at first? What should they what should they uh look at? My website, so remember I I do private coaching. I have a lot of sort of VIP clients and then we do groups, right?

And so there isn't I would say my Instagram account, which is the exact same thing, cash conferencial, it's the same. I would go to my Instagram account'cause there's a lot of knowledge to share there in terms of everything from toxins to food to, you know, everything you want to know. uh I think is seeking more. We're gonna host a webinar for them, right? And uh I uh between however this happens, they'll be informed on how to do that. Live QA. So we don't do this often, but

you know, given whoever's here for you guys only. This is not for the outside world, it's literally for whoever's in this summit. We're gonna host a live QA. I would say come to that and then we can drill into your personal stuff and you don't need to feel stuck.

Aging Is Optional

Yep, sounds good. So we'll be sending out more information as far as that goes. Uh but in the meantime, check out Kashif Khan on Instagram as well. So you can get a lot of great information there. And Kashif, any last words of inspiration here for our audience? Yeah, I would say that I did not believe this until I did the work. Remember, I didn't come from the healthcare industry or wellness industry. I I I stumbled upon it to heal myself.

And then it was so empowering and I I kinda found a sense of purpose, so I I just kept going, right? So what I've learned is that chronic disease and the pace at which you age is optional. It's a choice. I didn't know that. I thought that it's like just like every it's a thing that comes with aging. It's like cardiovascular disease is is is in my family. It's it's not true, right? The things that my dad had when he was my age, I just watched him sick my whole I I only knew my dad is being sick.

growing up, right? I don't have any of those things. In fact, I'm I'm healthier now at forty six than I was in my twenties. So I just tell you that if you use all this information in this incredible summit, listen to all the experts. You're you should be able to have a plan for like how to make chronic disease optional.

How to make the the your your brain's power and strength and longevity optional. It now it's a why do I say optional? You have to do the work, right? As long as you choose this path and do the work. It is an option. If you don't do the work, then you may end up like the everybody else, which is like susceptible to whatever you expose yourself to. So learn, do the work, and the pace at which you age is truly optional. Beautiful. That's right.

Podcast Wrap Up

So there you go. All right. Thanks so much, Kasheep, and everybody will see you on a future interview and everybody be me today. And if there was something you heard in this interview that you have questioned Or you want to dive in. Dr. Jocker's If you enjoyed this episode Please consider taking just a couple of things. And transform. Something valuable. Please share it with someone in your life. soon on a future Tax Pengar till barn kanske fonden för då. Du kan läkna rädda mig.

Lilla sifte sommar sight swish på 90-20 minut.

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