Learn what age-related macular degeneration (AMD) is What causes AMD The types of AMD The update on NAION - listen to last year's podcast all about it Why we aren't too concerned Click here to join Dr. Spencer's online clinic Vineyard Click to read the JAMA AMD article Click to read the Ophthalmology journal AMD article Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Jun 23, 2025•34 min•Ep. 123
Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopause Weight management in women is influenced by hormonal changes throughout life stages. Retrospective analyses can provide insights but have limitations. The wellness industry often oversimplifies complex medical issues. Hormonal replacement therapy may have subtle benefits for weight management. Confounding factors like SSRIs can complicate weight loss efforts. A holistic approach is essential f...
Jun 12, 2025•28 min•Ep. 122
Dr. Grant Tinsley joins the discussion as the body composition expert. Myostatin is a key regulator of muscle growth. Wendy Whippete the most jacked muscled up dog The concern of GLP-1 receptor agonists and muscle mass loss. Overview of Courage trial looking at semaglutide and trevogrumab and lean mass loss Upcoming Believe trial coming out (bimagrumab and semaglutide) Exercise remains crucial for muscle health and function. MRI data from SURPASS MRI provides new insights into muscle volume chan...
Jun 06, 2025•28 min•Ep. 121
Takeaways: The MAHA report aims to address public health issues but lacks actionable policies. Historical context is crucial for understanding current dietary guidelines. Funding for nutrition research has been inadequate, impacting the quality of data. Public perception of nutrition often outpaces scientific evidence. The evolution of dietary guidelines reflects political and social influences. There is a need for more rigorous nutrition science to inform policy. The dietary guidelines have not...
May 29, 2025•56 min•Ep. 120
Click to read Joy Prescriptions Drs. Karl and Spencer talk to Dr. Tiffany Moon all about Joy Prescriptions. Learn how to stop chasing perfection and embrace connection. 00:00Introduction to Dr. Tiffany Moon 02:02Journey to Reality TV: The Real Housewives of Dallas 05:58Life After Reality TV: Finding Joy and Purpose 09:59The Joy Prescription: A New Approach to Life 17:01Work-Life Integration: Balancing Career and Family 22:09Empowering Women: The Lead Her Summit 22:33Tiffany's Journey: From Child...
May 13, 2025•47 min•Ep. 119
Tirzepatide is more effective for weight loss than semaglutide. Cost-effectiveness is crucial in prescribing weight loss medications. Patients with severe obesity should receive more expensive medications for better outcomes. Both medications show significant benefits for obesity-related conditions. Long-term studies indicate sustained weight loss with both drugs. Gender differences affect weight loss outcomes with these medications. Safety profiles show tirzepatide may be better tolerated than ...
May 12, 2025•21 min•Ep. 118
Takeaways MASH is a significant obesity-related complication. Semaglutide shows promise in treating MASH. Weight loss is crucial for improving liver health. Bariatric surgery remains the most effective treatment. The Essence trial indicates a 63% resolution of NASH. New medications are being developed for obesity treatment. Early intervention is key to preventing severe liver damage. Accessibility of medications is a major concern. Comparative studies are essential for evaluating new treatments....
May 02, 2025•22 min•Ep. 117
Drs. Karl and Spencer chat with return guest Dr. Lauren Semple about creatine, protein, cortisol, fasting exercise, and training in women. Follow Dr. Lauren's instagram Join Dr. Spencer's online clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Apr 25, 2025•37 min•Ep. 116
Drs. Karl and Spencer discuss a new study looking at tirzepatide and metabolic rate. They also discuss a patient case of tirzepatide induced anhedonia. Here is the tirzepatide study If interested in joining Dr. Spencer's clinic Vineyard - Click Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Apr 11, 2025•25 min•Ep. 115
Drs. Karl and Spencer discuss the claim that GLP-1 meds cause more fat cells. Learn about if and how GLP-1 meds increase fat cells and what that means along with other claims about these medicine. Join Dr. Spencer's online clinic that specializes in GLP-1 medicines Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Mar 19, 2025•26 min•Ep. 114
Drs. Karl and Spencer talk to Dr. Kenneth Qiu all about direct medical care - the future of medicine. Learn about how bypassing insurance and creating a relationship directly with a doctor can improve your health and save money in the long run. Follow Dr. Qiu on Linked in See Dr. Spencer's direct care model with Vineyard Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Mar 11, 2025•23 min•Ep. 113
Drs. Karl and Spencer discuss with Dr. Grant Tinsley all about the new analysis of how much "lean mass" is lost with tirzepatide, the most powerful medicine available for weight loss. Learn: The difference between fat free mass and lean mass and lean soft tissue and muscle. If GLP-1 medicines cause muscle loss specifically How to minimize muscle loss when taking these medicines Our new study together. Click here for the tirzepatide paper Click here to see Dr. Grant Tinsely's Instagram Click here...
Feb 28, 2025•28 min•Ep. 112
Drs. Karl and Spencer discuss how bad the Hims and Hers ad was. From an outside perspective, the ad may have seemed good. But when you dig deeper, it was actually really bad. Listen to learn. Join Dr. Spencer's new online clinic - Vineyard. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Feb 17, 2025•25 min•Ep. 111
Drs. Karl and Spencer chat with NMN and NAD expert Dr. Charles Brenner all about these supposed longevity supplements. Learn about NAD metabolism Whether it's worth supplementing or not with NAD or NMN Follow Dr. Brenner on Twitter Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Feb 12, 2025•39 min•Ep. 110
Drs. Karl and Spencer chat with Dr. Fatima Cody Stanford all about obesity, genetics, and her appearance on 60 minutes. Does Dr. Sanford believe lifestyle doesn't matter for obesity? Find out by listening! Watch Dr. Stanford's 60 minute clip Join Dr. Spencer's Obesity Clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Jan 28, 2025•46 min•Ep. 109
Drs. Karl and Spencer chat about the new Lancet Commission's report on Clinical Obesity along with the new study on high dosed Wegovy. Learn: How 7.2 mg of Wegovy (semaglutide) compares to 2.4 mg What the proposed definitions of clinical and preclinical obesity are Click here to join Dr. Spencer's new online clinic Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Jan 20, 2025•29 min•Ep. 108
Drs. Karl and Spencer chat with Dr. Sowa about her book The Ozempic Revolution. Learn: Why she wrote the book. The top 3 things to know when starting a GLP-1 medicine. Also hear the top criticism from Drs. Karl and Spencer. You will laugh. Click here to get the book If you're on a GLP-1 currently and want to switch to Dr. Spencer's new clinic, Click Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Jan 10, 2025•31 min•Ep. 107
Drs. Karl and Spencer discuss the concept of "microdosing" GLP-1 receptor agonists along with talk about the new top line results from REDEFINE which studied the new drug CagriSema. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Dec 23, 2024•40 min•Ep. 106
Drs. Karl and Spencer chat with Dr. Lauren Colenso-Semple all about how the menstrual cycle and how it should affect your workout programming. Should you change your workouts around your menstrual cycle? Find out by listening! Check out her instagram Read her paper on exercise and menstrual cycles Read her paper on protein synthesis throughout the menstrual cycle Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advert...
Dec 18, 2024•30 min•Ep. 105
Drs. Karl and Spencer discuss the topline results from Surmount 5 which put Zepbound (tirzepatide) against Wegovy (semaglutide) for weight loss. They also discuss some news around compounded GLP-1s. Learn: Weight loss and glycemic differences between tirzepatide and semaglutide What the FDA is thinking for compounded GLP-1s If you're not on Dr. Spencer's virtual clinic waitlist, click here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use ...
Dec 09, 2024•44 min•Ep. 104
Drs. Karl and Spencer chat with Dr. Shivani Misra, a metabolic specialist physician researcher from the UK, all about the various forms of diabetes mellitus. Learn: The types of diabetes mellitus The monogenic forms (some what refer to as MODY) The differences within type 2 diabetes Whether CGMs (continuous glucose monitors) are useful If low carb could help some Follow Dr. Misra on X/Twitter Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and u...
Nov 25, 2024•1 hr 6 min•Ep. 103
Drs. Karl and Spencer chat with AtlasMD - Dr. Josh Umbehr all about making healthcare cheaper using direct primary care. Learn: How cheap labs and and meds should be How cutting out the middlemen can help healthcare and decrease costs Find AtlasMD here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Nov 20, 2024•1 hr 9 min•Ep. 102
Drs. Karl and Spencer discuss the brand new 3 year study of tirzepatide in those with prediabetes along with a discussion on semaglutide treating osteoarthritis. Learn: If people lose weight and keep it off with tirzepatide How many people regain weight after stopping the medicine Long-term side effects If semaglutide helps with osteoarthritis Click here to read the tirzepatide study Click here to read the semaglutide study Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for inform...
Nov 14, 2024•45 min•Ep. 101
Drs. Karl and Spencer invite Dr. Andrea Love back to the podcast to discuss a recent Joe Rogan podcast with Calley and Casey Means along with the concept of Make America Healthy Again and RFK jr. Learn: What the docs agree with. What they don't agree with. Is raw milk okay? Are cancer rates rising? and more Follow Dr. Andrea here https://www.instagram.com/dr.andrealove Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for ...
Nov 01, 2024•53 min•Ep. 100
Drs. Karl and Spencer discuss all things cortisol and poke fun at the influencers who try to fear monger exercise due to cortisol increases. Learn: What is cortisol and what does it do? Is cortisol bad? Should you worry about cortisol increases with exercise? Should you take supplements to lower cortisol? and more Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Oct 15, 2024•31 min•Ep. 99
Drs. Karl and Spencer discuss their ideal healthcare delivery system. Learn: Spencer's journey building and selling Sequence and what he wants to do next. How Dr. Karl believes healthcare should be and what he's doing next. Click here to get on Dr. Spencer's waitlist Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Oct 02, 2024•22 min•Ep. 98
Drs. Karl and Spencer discuss BS supplements claiming to be like Ozempic along with discuss some new obesity drugs coming down the pipeline that were announced in phase 1 and 2 trials. Are there any supplements that can mimic Ozempic? What is amylin and how does it help with weight and sugars? What is this new oral drug "amycretin" in phase 1 trials? and more Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertisin...
Sep 16, 2024•40 min•Ep. 97
Drs. Karl and Spencer chat with Dr. Jen Gunter all about menopause. Learn: How it's diagnosed. When and when not to treat. The various treatment. If it is indicated for cardiovascular disease prevention or body composition. Whether or not you should get labs. See more at Dr. Gunter's website Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Sep 09, 2024•1 hr 16 min•Ep. 96
Drs. Karl and Spencer talk about the top line results from study showing liraglutide may have some benefit in Alzheimer's along with top line results from the Summit trial showing heart failure benefits with tirzepatide. They also discuss the women's boxing controversy and BMI in athletes. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Aug 07, 2024•27 min•Ep. 95
Drs. Karl and Spencer chat with return guest and bone expert endocrinologist Dr. Rachel Pessah-Pollack all about the new Vitamin D guidelines. Should healthy people even check a vitamin D level? Should they supplement with vitamin D? What people should check or supplement? Click here for the new guidelines Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising....
Jul 30, 2024•31 min•Ep. 94
