This month on Episode 73 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research . This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness. Article highlights: Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium He, et al. NEP in Placental EVs Triggers Hypertension in PE ...
Jun 19, 2025•37 min
This month on Episode 72 of Discover CircRes , host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research . This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF Article highlights: Laudette, et al. PCSK9 and Mitochondrial Cholesterol in Heart Yang, et al. Srsf3 Limits AS by Le...
May 15, 2025•35 min
This month on Episode 71 of Discover CircRes , host Cindy St. Hilaire highlights three articles featured in the March 28th and April 11th issues of Circulation Research . This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice. Article highlights: Han, et al. PRL2 Dephosphorylates AMPKα2 in Heart Perelli, et al...
Apr 17, 2025•35 min
This month on Episode 70 of Discover CircRes , host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women . Article...
Mar 20, 2025•34 min
This month on Episode 69 of Discover CircRes , host Cindy St. Hilaire highlights four articles featured in the January 31st and February 14th issues of Circulation Research . This Episode also includes a discussion with Dr Frank Conlon and graduate student Ike Emerson about their study, X Chromosome-Linked MicroRNAs Regulate Sex Differences in Cardiac Physiology. Article highlights: Huang, et al. Vps4a Safeguards Plasma Membrane Integrity Liu, et al. PPM1B Deubiquitination Promotes Arterial Stif...
Feb 20, 2025•34 min
This month on Episode 68 of Discover CircRes , host Cindy St. Hilaire highlights four articles featured in the January 3rd and January 17th issues of Circulation Research . This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy. Article highlights: Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis Johansen, et al. TCF21 and Cardiac Fibrosis Pabon, et al. E...
Jan 16, 2025•34 min
This month on Episode 67 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research . This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function . Article highlights: Bardhan, et al. Sex Specific Roles of Microbiota in Hypertension Ma, et al. Kindlin-2 LLPS Controls Vascular Stability Wang, et al. CAR-Ms Alleviate Myocardial I/R Injury...
Dec 19, 2024•26 min
This month on Episode 66 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research . This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation. Article highlights: Lou, et al. Visualizing irAEs in Atherosclerosis Yoshii, et al. Defective Mitophagy Response in HFpEF Heart Zeller, et al. Shear St...
Nov 21, 2024•41 min
This month on Episode 65 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the September 27th and October 11th issues of Circulation Research . This Episode also includes a discussion with Dr Ken Walsh and Dr Ariel Polizio about their study, Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism. Article highlights: Ju, et al. NAE1 Crotonylation Regulates Cardiac Hypertrophy Pirri, et al. EPAS1 Atheroprotecti...
Oct 17, 2024•39 min
This month on Episode 64 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the August 30th and September 13th issues of Circulation Research . This Episode also includes a discussion with Drs Stephanie Chung, Ahmed Gharib, and Khalid Abd-Elmoniem from NIDDK about their study, Endothelial Dysfunction in Youth-Onset Diabetes Type 2, A Clinical Translational Study. Article highlights: Zhao, et al. AMPK Phosphorylation of β-Arrestin-1 Blocking β-AR Bashore, et al. Monocyte...
Sep 19, 2024•34 min
This month on Episode 63 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the August 2nd and August 16th issues of Circulation Research . This Episode also includes a discussion with Drs Chen Gao and Yibin Wang about their study, Glucagon Receptor Antagonist for Heart Failure with Preserved Ejection Fraction Article highlights: Douvdevany, et al. Imaging the Turnover of the Sarcomere Quelquejay, et al. Wnk1 Deletion in Smooth Muscle Cells Induces Aortitis Paulke, et a...
Aug 15, 2024•33 min
This month on Episode 62 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the July 5th and July 19th issues of Circulation Research . This Episode also includes a discussion with the four finalists for the Basic Cardiovascular Sciences Outstanding Early Career Investigator Award. Article highlights: Mallaredy, et al. Extracellular Vesicle Reduction Prevents Heart Failure Mori, et al. CD163 Macrophages and EndMT in Plaque Progression Wang, et al. Rbx2 Regulates Mitopha...
Jul 18, 2024•46 min
This month on Episode 61 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the June 7th and June 21st issues of Circulation Research . This Episode also includes a discussion with Dr Chris O'Callaghan and Jiahao Jiang from the University of Oxford about their study, A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Article highlights: Compendium on Interface Between Cardioimmunology, Myocardial Health, and Disease Zafeiropoulo,...
Jun 20, 2024•28 min
This month on Episode 60 of Discover CircRes , host Cindy St. Hilaire highlights original research articles featured in the May 10 and May 24th issues of Circulation Research . This Episode also includes a discussion with Dr Sophie Astrof and Dr AnnJosette Ramirez from Rutgers University about their study, Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease. Article highlights: Tamiato, et al. Pericyte RGS5 in Cardiac Aging Zifkos, et al. PTP1B and Venous Thromboinfl...
May 16, 2024•36 min
This month on Episode 59 of Discover CircRes , host Cindy St. Hilaire highlights original research articles featured in the April 12 and April 26th issues of Circulation Research . This Episode also includes a discussion with Dr Craig Morrell and Chen Li from University of Rochester about their study, Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function. Article highlights: Arkelius, et al. LOX-1 and MMP-9 Inhibition Improves Stroke Outcomes Cruz, et al. C122Y Disrupts Kir...
Apr 18, 2024•31 min
This month on Episode 58 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the March 1 and March 15th issues of Circulation Research . This Episode also includes a discussion with Drs Frank Faraci, Tami Martino, and Martin Young about their contributions to the Compendium on Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease . Article highlights: Yan, et al. GCN2 in Ponatinib-Induced Cardiotoxicity Wang, et al. Activating v-ATP...
Mar 21, 2024•40 min
This month on Episode 57 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the February 2nd and February 19th issues of Circulation Research . This Episode also includes a discussion with Dr Kathryn Howe and Dr Sneha Raju from University of Toronto, about their manuscript titled Directional Endothelial Communication by Polarized Extracellular Vesicle Release . Article highlights: Ren, et al. ZBTB20 Regulates Cardiac Contractility Faleeva, et a...
Feb 15, 2024•36 min
This month on Episode 56 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the January 5th and January 19th issues of Circulation Research . This Episode also includes a discussion with Dr Julie Freed and Gopika Senthilkumar from the Medical College of Wisconsin about their study, Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease. Article highlights: He, et al. T Cell LGMN Deficiency Prevents Hyperten...
Jan 18, 2024•30 min
This month on Episode 55 of Discover CircRes , host Cynthia St. Hilaireaire highlights two original research articles featured in the December 8th issue of Circulation Research . This Episode also includes a discussion with Dr José Luis de la Pompa and Dr Luis Luna-Zurita from the National Center for Cardiovascular Research in Spain about their study, Cooperative Response to Endocardial NOTCH Reveals Interaction With Hippo Pathway. Article highlights: Shi, et al. Nat10 Mediated ac4C in Cardiac R...
Dec 21, 2023•29 min
This month on Episode 54 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the October 27th and November 10th issues of Circulation Research . This Episode also includes a discussion with Dr Sophie Susen and Dr Caterina Casari about their study, Shear Forces Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia, published in the October 27th issue. Article highlights: Pass, et al. Single Nuclei Transcriptome of PAD Muscle Liu, et a...
Nov 16, 2023•27 min
This month on Episode 53 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the September 29th and October 13th issues of Circulation Research . This Episode also includes a discussion with Dr Margaret Schwarz and Dr Dushani Ranasinghe about their study, Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension , published in the September 29 issue. Article highlights: Serio, et al. p300/CBP-Upregulated ...
Oct 19, 2023•28 min
This month on Episode 52 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the September 1 and September 15th issues of Circulation Research . This Episode also includes a discussion with Dr Manuel Mayr about the study, Proteomic Atlas of Atherosclerosis, the Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes and Outcomes , published in the September 15 issue. Article highlights: Sun, et al. CCND2 modRNA Remuscularization Hear...
Sep 21, 2023•32 min
This month on Episode 51 of Discover CircRes , host Cynthia St. Hilaire highlights four original research articles featured in the August 4th and August 18th issues of Circulation Research . This Episode also includes a discussion with Dr Eric Small and Dr Xiaoyi Liu from the University of Rochester Medical Center about their article p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricular Pressure Overload , published in the July 21st issue of the journal. Article h...
Aug 17, 2023•32 min
This month on Episode 50 of Discover CircRes , host Cynthia St. Hilaire highlights four original research articles featured in the June 23, July 7, and July 21 issues of Circulation Research . This Episode also includes a discussion with BCVS Outstanding Early Career Investigator Award Qiongxin Wang from University of Washington St. Louis, Haobo Li from Massachusetts General Hospital, and Asma Boukhalfa from Tufts Medical Center. Article highlights: Tong, et al. The Role of DRP1 in Mitophagy Abe...
Jul 20, 2023•34 min
This month on Episode 49 of Discover CircRes , host Cynthia St. Hilaire highlights two original research articles featured in the May 26th issue and provides an overview of the June 9th Compendium on Early Cardiovascular Disease of Circulation Research . This Episode also includes a discussion with Dr Tejasvi Dudiki and Dr Tatiana Byzova about their study, Mechanism of Tumor Platelet Communications in Cancer. Article highlights: Nichtová, et al. Mitochondria-SR Tethering and Cardiac Remodeling F...
Jun 15, 2023•27 min
This month on Episode 48 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the April 28th issue of Circulation Research . This Episode also includes a discussion between Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova, who all contributed to manuscripts to the May 12th Compendium on Covid-19 and the Cardiovascular System. Article highlights: Heijman, et al. Mechanisms of Enhanced SK-Channel Current in AF Chen, et al. IL-37 Attenuat...
May 18, 2023•36 min
This month on Episode 47 of Discover CircRes , host Cynthia St. Hilaire highlights three original research articles featured in the March 31 issue of Circulation Research . We’ll also provide an overview of the Compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease published in the April 14 issue. Finally, this episode features an interview with Dr Elizabeth Tarling and Dr Bethan Clifford from UCLA regarding their study, RNF130 Regulates LDLR Availability and Plas...
Apr 20, 2023•34 min
This month on Episode 46 of Discover CircRes , host Cynthia St. Hilaire highlights four original research articles featured in the March 3 and March 17th issues of Circulation Research . This episode also features an interview with Dr Andrew Hughes and Dr Jessilyn Dunn about their review, Wearable Devices in Cardiovascular Medicine. Article highlights: Delgobo, et al. Deep Phenotyping Heart-Specific Tregs Sun, et al. Inhibition of Fap Promotes Cardiac Repair After MI Sun, et al . Endosomal PI3Kγ...
Mar 16, 2023•35 min
This month on Episode 45 of Discover CircRes , host Cynthia St. Hilaire highlights four original research articles featured in the February 3rd and February 17th issues of Circulation Research . This episode also features an interview with Dr Hind Lal and Dr Tousif Sultan from the University of Alabama at Birmingham about their study Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation. Article highlights: Pi, et al. Metabolomic Signatures in PAH Carnevale, et al. Throm...
Feb 16, 2023•31 min
This month on Episode 44 of Discover CircRes , host Cynthia St. Hilaire highlights four original research articles featured in the January 6th and January 20th issue of Circulation Research . This episode also features an interview with Dr Timothy McKinsey and Dr Marcello Rubino about their study, Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. Article highlights: Prasad, et al. ACE2 in Gut Integrity and Diabetic Retinopathy Cui, et al. Epsins Regulate Lipid Metabolism and ...
Jan 19, 2023•31 min
