Send us a text This episode is brought to you by Hamamatsu . Thank you Hamamatsu :) So...you are already doing digital pathology in your institution but would like to scale it, take it to the next level? How do you do it, where do you start? In this episode my guest, Mark Zarella, PhD (previously Johns Hopkins University, currently Mayo Clinic) explains how he did exactly that at Johns Hopkins University. He talks about: What is important when evaluating whole slide scanners and how to choose th...
Nov 08, 2022•30 min•Ep. 49
Send us a text As the digital pathology community is embarking on the journey of DICOM implementations questions we haven't asked ourselves arise... Is DICOM and image format or is it a standard? What is the difference? Are all the DICOM images the same or do they differ? how do the differences influence the technology developments and workflows? Is there a single best way of implementing DICOM or do we need to keep iterating? And who can help us on this journey? Who would be a better guest...
Oct 28, 2022•43 min•Ep. 48
Send us a text Join me for the FREE Independent Digital Pathology Event "Bridging the Gap Between Pathology and Computer Science" 👇 REGISTER HERE Support the show Become a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!...
Oct 22, 2022•29 min•Ep. 47
Send us a text Did you know that pathology diagnostics through a smartphone is a thing? Really and officially! It is called static telecytology and a lot has already been published on it (see RESOURCES BELOW). This episode's guest, Dr. Kate Baker, a veterinary clinical pathologist, developed a smartphone app for veterinary telecytology! This digital pathology smartphone app is called pocket pathologist and let's you get access to a veterinary pathologist opinion remotely. This app was ...
Oct 10, 2022•51 min•Ep. 46
Send us a text This is a joint podcast episode where the hosts of "Beyond the Scope" - the official Digital Pathology Association podcast and the host of the "Digital Pathology Podcast" meet to talk about what is going on in our discipline. Together David Tulman, Giovanni Lujan, and Aleksandra Zuraw cover the current digital pathology topics such as digital pathology guidelines for clinical and non-clinical pathology, digital pathology adoption in clinical pathology settings ...
Sep 16, 2022•35 min•Ep. 45
Send us a text Have you ever wondered what semi-supervised, weekly, and unsupervised artificial intelligence digital pathology models can do to help pathologists? Can we finally stop annotating??? This episode's guest Geert Litjens - a member of the computational pathology group at Radboud University Medical Center explains how semi-supervised and weekly supervised artificial intelligence-based image analysis can help pathologists do better, more time-efficient, and data-efficient digital p...
Jul 28, 2022•53 min•Ep. 44
Send us a text There are a few websites online other than the Digital Pathology Place that talk about different aspects of digital pathology. An important one being Pathology News . Pathology News is an online place bringing together the digital pathology vendors and purchasers. It is meant to be a single community for everyone working in the digital pathology space. A community working together on advancing the digital pathology science. A unique (and my favorite!) feature of the website, NOT A...
Jul 05, 2022•22 min•Ep. 43
Send us a text Deep learning artificial intelligence has entered the field of digital pathology and is here to stay because it consistently outperforms the classical image analysis methods on pathology slides. The only caveat is that to train good deep learning image analysis models we need a lot of whole slide images. Where do we get them? Is there a central repository that can be used for this purpose? Good news, there is one in the making! There is an ongoing project to create a very large re...
Jun 17, 2022•37 min•Ep. 42
Send us a text Digital pathology is supposed to help pathologists provide better patient care and make their lives easier, but what about other doctors, do they even care? Maybe radiologists? Oncologists? Nope… Dermatologists! They do care! And they are the clients of Pathology Watch – a CLIA lab specializing in dermatopathology, that is currently servicing samples from over 65 dermatology clinics in the USA. Pathology Watch provides an end-to-end digital pathology solution for dermatologists. F...
Apr 25, 2022•23 min•Ep. 41
Send us a text A common misconception about digital pathology is that it is synonymous with whole slide imaging and has a high price point. This is not the case, as one can enter the digital pathology world and benefit from what it has to offer with a simple microscope camera. If we would like a more sophisticated solution, but don't want to get a whole slide scanner or don't have the use case or business case to justify it, no worries, there is enough to choose from! In this episode, ...
Apr 14, 2022•34 min•Ep. 40
Send us a text This episode is brought to you by Visiopharm . With the regulatory approvals of whole slide imaging systems, digital pathology became the modality for routine diagnostics. Digitalization of pathology is aiming at increasing precision and productivity in the pathology lab, but the adoption of this field is slower than expected. One of the causes of the slow adoption is that going digital in a pathology lab means a much bigger investment than just the cost of the whole slide scanner...
Mar 15, 2022•20 min•Ep. 39
Send us a text Visiopharm is a company offering image analysis software used on pathology images. The software has been on the market for over 20 years and has evolved through the transition of digital microscopy to digital pathology. Digital microscopy provided static tissue images captured through the microscope camera and only branched out into digital pathology with the wider availability and adoption of whole slide scanners. Image analysis spans digital microscopy and digital pathology, and...
Mar 08, 2022•19 min•Ep. 38
Send us a text Even though tissues are tridimensional structures, most tissue research is done on two-dimensional tissue slides. This leaves a tremendous amount of biological information on the table. This episodes' guest - Sharla White, Ph.D., the vice president of research and development at ClearLight Biotechnologies explains how tissue clearing and 3D immunofluorescence can take your tissue research to a whole new level. With the rise of immuno-oncology, the importance of immune cell in...
Feb 07, 2022•1 hr 2 min•Ep. 37
Send us a text The Digital Imaging and Communications in Medicine (DICOM) standard for digital medical imaging has been around since the 1980s . First adopted in radiology it is slowly spreading in pathology as well. Now with image analysis being an integral part of medical imaging workflows, the question arose if the annotations made on the images should have a standard format as well? And can the same DICOM format be used? With deep learning taking over the medical image analysis field, the an...
Jan 25, 2022•36 min•Ep. 36
Send us a text In the world of anatomic digital pathology, the mention of digital cytology usually causes thoughts of all the challenges associated with it. We are often not aware that digital pathology and image analysis applications started with digital hematology and cytology (e.g. image analysis-based pap smear evaluation) and that in veterinary medicine digital cytology is a booming discipline. Today’s episode’s guest, Dr. Kate Baker, is a board-certified veterinary clinical pathologist who...
Jan 11, 2022•42 min•Ep. 35
Send us a text In this episode, we talk with Heather Couture about how to make deep learning models for tissue image analysis more robust to domain shift. Supervised deep learning has made a strong mark in the histopathology image analysis space, however, this is a data-centric approach. We train the image analysis solution on whole slide images and want them to perform on other whole slide images - images we did not train on. The assumption is that the new images will be similar to the ones we ...
Dec 29, 2021•17 min•Ep. 34
Send us a text Advanced computer science expertise with the ability to code and a medical degree with over 20 years of clinical experience is a rare combination. This episode’s guest, Martin Weihrauch MD , the co-founder of Smart in Media incorporates this rare combination. His digital pathology platform originated when he was asked by a pharmaceutical company to provide some interactive entertainment for the participants of a medical congress, something beyond just coffee, and the only thing re...
Dec 14, 2021•39 min•Ep. 33
Send us a text What do cancer and climate change have in common? Both are very serious problems and in both, machine learning (ML) and artificial intelligence (AI) can be used to support potential solutions. Even though these AI applications may seem very different the ML methods used to support work on both problems are very similar. Today’s episode’s guest, Heather Couture from Pixel Scientia Labs does exactly that – fights cancer and climate change with AI. She is a computer scientist special...
Nov 28, 2021•36 min•Ep. 32
Send us a text AI-powered algorithms for digital pathology and tissue image analysis are not new, also digital cytology and hematology already have their share of AI algorithms helping pathologists with faster and more accurate diagnoses. But what about parasitology or microbiology? Techcyte has a tool for that as well. Today my podcast guest is Ben Cahoon, the CEO of Techcyte, a software start-up that provides AI-powered diagnostic tools for everything smearable: fecal, blood, cytology, and mic...
Nov 03, 2021•42 min•Ep. 31
Send us a text This episode contains affiliate links. Learn what that means here Have you ever tried to take a picture through your microscope with your smartphone? If you have, you know how much hassle it is to consistently take good, sharp microscope pictures. So maybe, annoyed with how cumbersome it is and how much time it takes, you have already looked for a microscope phone adapter? I know I have, and the one I got from Amazon quickly ended up in my drawer and never saw the light of day aga...
Oct 18, 2021•36 min•Ep. 30
Send us a text How many times did you get annoyed when using non-intuitive digital pathology software? Have you already given up on digital pathology and image analysis or are you still looking for something powerful but easy to use? Today’s guest, Tuomas Ropponen, the chief technology officer at Aiforia, is talking about the creation of a pathology image analysis platform whose core principles are “easy to use” and “accessible” - Aiforia . Aiforia stands for artificial intelligence (AI) for ima...
Oct 05, 2021•40 min•Ep. 29
Send us a text With more than 170K total downloads and over 700 citations in scientific literature, QuPath is arguably the most popular open-source software for quantitative pathology and bioimage analysis. Today’s podcast guest, Pete Bankhead , the author of QuPath , is taking us behind the scenes of his software creation. Even though Pete is now a senior lecturer in digital pathology at the University of Edinburgh, his digital pathology career actually started by accident. With an undergraduat...
Sep 24, 2021•56 min•Ep. 28
Send us a text This episode is brought to you by Visiopharm Cancer immunotherapy, aka immuno-oncology, is tapping into the power of our own immune system to fight cancer. There are multiple processes and immune cell populations involved in tumor immunology and digital pathology and whole slide imaging has allowed scientists to leverage the power of tissue image analysis to detect and quantify them. Today’s podcast guest, Prof. Elfriede Noessner will walk us through the complexities of the immune...
Sep 06, 2021•35 min•Ep. 27
Send us a text Are you looking for a whole slide scanner for your digital pathology projects? In this podcast episode Doug Stapleton, the Service Manager of the digital slide scanner division of Hamamatsu , is guiding us through this process. He is listing 10 questions you need to ask before purchasing a whole slide scanner tailored to your digital pathology needs. Question 1: What is your budget and throughput? Question 2: What is your intended use now and in the future? Brightfield, immunofluo...
Jun 13, 2021•25 min•Ep. 26
Send us a text Have you ever wondered if the pathology turn-around time could be faster and came to the conclusion that the only way to achieve that is to skip the tissue sectioning and staining? Now it is possible, with optical scanning microscopy by Instapath. Today’s guest, David Tulman, is the chief clinical officer of Instapath, a small startup using optical scanning microscopy to image fresh tissue without fixing and staining it. Working as a clinical trial manager exposed David to differe...
May 16, 2021•35 min•Ep. 25
Send us a text This episode is brought to you by Visiopharm. In this third and last episode of the multiplex mini-series with Regan Baird from Visiopharm we look at the considerations when choosing an image analysis software for phenotyping. The two main points to consider when choosing phenotyping image analysis software are segmentation assistance and data visualization. Segmentation assistance : Before different markers are attributed to different cells in the tissue and cell phenotypes are d...
May 11, 2021•14 min•Ep. 24
Send us a text This episode is brought to you by Visiopharm. Multiplex tissue staining can generate large amounts of data to help identify distinct information about particular cells in tissue. Immuno-oncology is a field where it is common practice to use multiplexing, in particular for cell phenotyping in tissue. Phenotyping is the ability to classify every individual cell in the tissue based on the biomarker panel used. The panels are designed to identify cells of different lineages as well as...
May 04, 2021•11 min•Ep. 23
Send us a text Founded in 2011 by this episode’s guest, Lorcan Sherry, along with co-founder John Waller, OracleBio entered the digital pathology market with a unique value proposition – to be a contract research organization for tissue image analysis and help other organizations in their biomarker discovery work. Fast forward 10 years and they evolved from a small service provider into a Good Clinical Practice (GCP) compliant organization supporting clinical trials, but still within the same pa...
May 02, 2021•47 min•Ep. 22
Send us a text This episode is brought to you by Visiopharm. After experimenting with multidimensional, multimarker, and multicolor single-cell imaging modalities during his postdoc at Beth Israel Deaconess Medical Center in Boston, looking at 2D images of tissue stained just with hematoxylin and eosin (H&E) seemed to him a bit simplistic…and then he was tasked with doing tissue image analysis (IA). When relying just on H&E, IA can be a very challenging task. So, to both simplify it and ...
Apr 26, 2021•10 min•Ep. 21
Send us a text As a computer scientist, he knew that to make a real impact with image analysis there were only two areas: military and life sciences. Sylvain Berlemont, the founder of Keen Eye chose life sciences and never looked back. He started consulting for the industry during his biomedical image analysis research work in academia and he quickly saw that regardless of the applications, the questions asked and the problems to be solved were very similar. Patterns started to emerge and the ne...
Apr 04, 2021•31 min•Ep. 20
