Jen slept fine the night before she couldn’t. Just short of 29 years old and after years of excellent sleep, insomnia entered her life leading her down a years-long search for cures, treatments, or even just an explanation of why her life had been turned upside down. Jen Senior is the author of an article, “ Why Can’t Americans Sleep? ” in the Atlantic and she joins us to talk about the intersection of sleep, depression, anxiety, shame, and so much more. We also discuss sleeping pills, antidepre...
Jul 14, 2025•49 min•Ep. 218
Brandon Stickney remembers booze being everywhere growing up in Lockport, New York and he definitely remembers getting a taste for it growing up. Over time, he developed bipolar disorder and his substance use disorder added cocaine and opioids as favorite drugs. Brandon’s love of getting high would cost him his marriage, his successful career as a journalist and author, and his freedom, after getting busted selling drugs and being sentenced to two years in prison. He tells us about what it’s lik...
Jul 07, 2025•56 min•Ep. 217
When the comedian, actor, and author Maria Bamford has something to say about mental health, it’s a pretty good idea to give a listen. For one reason, she’s hilarious. Also, she comes at the issue not just as an observer. Maria has a long history with mental health conditions. SHe has spent a good bit of time in in-patient facilities, has dealt with problematic intrusive thoughts, and has been diagnosed with bipolar disorder, type 2. Maria talks about the issue of access to mental health treatme...
Jun 30, 2025•49 min
Hollywood doesn’t exactly have a stellar track record when it comes to portraying mental illness in a sensitive, honest, and appropriately complex way (think Psycho or the notorious caffeine pill episode of Saved by the Bell ). But the top show on Netflix right now, Ginny & Georgia went to great lengths to show mental health conditions honestly. The series tells the story of Georgia, a mother with a traumatic background, Ginny, her daughter with a habit of self-harming, and it includes chara...
Jun 23, 2025•43 min•Ep. 216
"Beneath the Lilypad" is singer-songwriter Alexandra Savior's third album, but her first in five years. Several years ago, she was diagnosed with bipolar disorder, type 1. That’s a condition marked with manic highs that can last for weeks or months as well as crushing lows of depression, she’s had both, you’ll hear about that. She’s also dealt with psychosis, and has spent time in an in-patient facility. That mental health journey has informed her work as a songwriter and a musician and inspired...
Jun 16, 2025•46 min•Ep. 215
As temperatures and sea levels rise, the effects of climate change are being felt in weather patterns, natural disasters, and in both public and personal mental health. We talk with Dr. Caroline Carney, President of Behavioral Health and Chief Medical Officer at Magellan Health in Phoenix about the connection between your mind and the dire conditions Earth is facing. She says the damage is being done by the traumatic effects of fires, floods, and other severe weather incidents but also by the gn...
Jun 09, 2025•40 min•Ep. 214
Rep. Andrea Salinas (D-Ore.) is one of four chairs of the bipartisan Mental Health Caucus in the U.S. House of Representatives, a 93-member group of Republicans and Democrats pledging to fight stigma, improve accessibility, and generally make the country’s mental health better. But as the Trump administration floats huge cuts to Medicaid and other social services and as the tone of politics in America gets more divided and vitriolic, does a well-intentioned group like that really have a chance t...
Jun 02, 2025•52 min•Ep. 213
Ethan Sacks is a veteran comics writer, having created stories for Marvel, DC, and numerous Star Wars comics. In the comic A Haunted Girl , Ethan enlisted his daughter Naomi as co-writer to tell a story much more personal than anything involving Star Wars or the Avengers. A Haunted Girl tells the story of Cleo, a character inspired by Naomi’s real life experiences in her teens dealing with depression, anxiety, and suicidality. She spent time in in-patient facilities and now, at 21, is doing bett...
May 26, 2025•45 min•Ep. 212
It would take an entire section of show notes here to list all the things Felicia Day has accomplished in her career. Here’s an attempt at making that brief: acted in a bunch of TV shows you know, created and starred in web series, made just so very many online videos, and is now the author and star of an audiobook called Third Eye about someone who is supposed to save the world but fails. In our interview, Felicia talks about doing all those things while dealing with mental disorders like depre...
May 19, 2025•44 min
Aperture is the sixth studio album by the indie-folk band The Head And The Heart and it’s kind of a return to the more grounded, collaborative sound of their earliest work. It’s less polished, less highly produced, not as poppy. That’s not an accident. The band has been putting in the work to be more of a cohesive unit by sharing songwriting and singing duties, going to therapy together, and trying to closely protect the health of both the individual members and the group itself. Kenny Hensley j...
May 12, 2025•41 min•Ep. 211
There have been ten million contacts, via phone calls, texts, and chats, with the 988 Suicide & Crisis Lifeline since it first launched in July of 2022. As its third anniversary approaches, we check in to see how the system is holding up, what the funding and capacity issues are, and what the future might look like with our guest, Hannah Wesolowski, Chief Advocacy Officer for the National Alliance on Mental Illness (NAMI). We also examine the potential threat to the LGBTQ specialized service...
May 05, 2025•39 min•Ep. 210
Would you open your heart to a bot? Tell it all your problems? Look to a piece of code, a computer program, for high-quality mental healthcare? Some people have said yes and the results are hard to ignore. Dartmouth University test subjects who sought help from Therabot, a generative AI chatbot, showed a 51% reduction in depression symptoms, 31% for anxiety, 19% for eating disorders. Dr. Nicholas Jacobson, who led the study, says people really bonded with Therabot, called it Thera for short, and...
Apr 28, 2025•48 min•Ep. 209
If you were brought up in a family or a culture that never recognized, discussed, or processed things like depression and trauma, you may have learned to simply hide those difficult feelings away and simply act as if everything’s great. You can be a high achiever, striving perfection, all to keep away demons that you’ve never really faced. Your act can be so good that it even fools you. For a while, anyway. Until it doesn’t. And then things can get very ugly. Psychologist Dr. Margaret Rutherford...
Apr 21, 2025•48 min•Ep. 208
Cameron Esposito has many titles: hugely successful standup comedian, actor in television and film, writer, podcast host. After a recent rehab stay led to a mental health diagnosis, she has realized that she’s also a person with bipolar disorder, type II. Cameron has a new special, Four Pills , that’s part stand-up comedy and part reflection on the circumstances that led to this discovery as well as thoughts on what life as a treated person for bipolar will mean going forward. Cameron Esposito j...
Apr 14, 2025•44 min•Ep. 207
Statistics say that 23% of Americans are currently living with some form of mental illness. For most people, that calls for reaching out for help and receiving treatment and advice on management. But if you’re an FAA-approved airline pilot, disclosing that you have something like a depressive disorder or an anxiety problem can mean a temporary pause or permanent end to your entire career. Of course, having a mental illness, not disclosing or getting treatment, and flying anyway presents a variet...
Apr 07, 2025•38 min•Ep. 206
Hanif Abdurraqib is a MacArthur Fellow, accomplished poet, and critically lauded author of numerous books, including There’s Always This Year: On Basketball and Ascension , which is now out in paperback. He’s also a person who deals with major depressive disorder and numerous anxiety disorders. In a revealing, positive, and practical interview, Hanif talks about the numerous ways he cares for his mental health issues by both taking care of himself and building a strong community of other people ...
Mar 31, 2025•49 min•Ep. 205
Things are scary in this country these days for a lot of people. There is turmoil in the government, shakiness in the economy, and a deep divide over what America even means anymore. In times of upheaval, it’s a good idea to reach out to friends, see how they’re holding up, help carry their burdens and sorrows, and see what wise advice they can share about perseverance. We do this on our show from time to time. In this mini-episode, we check in on a good friend of the show Open Mike Eagle. He’s ...
Mar 26, 2025•20 min•Ep. 204
We’ve been seeing an influx of new listeners recently. It’s very exciting. Thank you for that and we’re delighted that you’ve joined us. So we thought we’d take a moment and explain what the show is all about and who it’s for. Spoiler alert: it’s for everyone, including you, regardless of your mental health history. It's the final week of the 2025 Max Fun Drive! Check out the fun thank you gifts and become a member of Max Fun ! Check out our I’m Glad You’re Here and Depresh Mode merchandise at t...
Mar 25, 2025•6 min•Ep. 203
“I’m very kind to Jim, I’m trying to take good care of Jim, I’m trying to love Jim,” says musician Jim James of the band My Morning Jacket. The kindness he’s showing Jim, himself, is a relatively new thing, he says, after a long time spent kind of beating up on the guy. As My Morning Jacket releases its new album, is, Jim reflects back on issues such as a need for validation through achievement, alcoholism, and depression. And he shares what he’s learned through intense therapy, meditation, EMDR...
Mar 24, 2025•1 hr 3 min•Ep. 202
In this bonus content edition of Depresh Mode, We’re joined by some Maximum Fun all-stars for some very light-hearted and delightfully competitive games that are as informative as they are silly. Our competitors: Justin McElroy of My Brother, My Brother, and Me , Adventure Zone , and Sawbones Hal Lublin of Tights & Fights and We Got This Laura Swisher, senior producer overseeing about a million Max Fun podcasts Who will win the game Antidepressant, Pokemon, or State Fair Food ? Who will emer...
Mar 20, 2025•6 min
It’s not MaxFunDrive without a wild kickoff spectacular! Former real-life VJ and host of MTV's Spring Break 1999, Dave Holmes, takes your favorite MaxFun hosts through some wacky ‘90s- and Spring Break-themed mini games!! Featuring: Dave Holmes, Jeremy Bent, Oscar Montoya, Dimitry Pompée, Tom Lum, Ellen Weatherford, Alex Schmidt, Brenda Snell, Drea Clark, Alonso Duralde, Dan McCoy, Jordan Morris, Manolo Moreno, Ella Hubber, Caroline Roper, Ella McLeod, John-Luke Roberts, Justin McElroy, Clint Mc...
Mar 17, 2025•1 hr 19 min
The alcohol, says J. Kenji Lopez-Alt, came about in young adulthood, when it solved persistent social anxiety and made him the life of the party. As Kenji found tremendous success in food writing and restaurateuring, he found that he couldn’t really make it through the day without downing between two and five drinks. This wasn’t hard to pull off in the food business, surrounded by booze and a culture that heartily encouraged its consumption. Kenji found that, as is so often the case with mental ...
Mar 17, 2025•54 min•Ep. 201
Maybe you’re one of those people who dreads even looking at the news these days, with stories of layoffs, tariffs, upheaval in foreign policy, and a lack of knowledge as to where this is all going and what it might mean for the future of America and the world. It’s a tumultuous time. When things are chaotic, it can be good to check in with one’s friends and that’s what Depresh Mode does this week. We have conversations of commiseration, of humor, and of hope with comedian and actor Paul F. Tompk...
Mar 10, 2025•51 min•Ep. 200
Lamb of God is a very popular heavy metal band with Grammy nominations, gold records, and a huge headbanging following. Randy Blythe, front man for the band and author of a new book, Just Beyond the Light , is in recovery from drugs and alcohol and tells stories of finding sobriety, including how it was pretty easy to stay sober while on an Australian vacation surrounded by koalas but a lot harder once he returned to the States and the old patterns and routines of his life. Randy also talks abou...
Mar 03, 2025•49 min•Ep. 199
Microdosing involves taking very small amounts of psychedelic substances such as LSD or psilocybin, maybe seven to twelve percent of a regular dose. It’s not enough to “trip out” but enough, proponents say, to yield very positive results, especially in terms of treating depression that hasn’t responded well to other methods. The catalog of extensive clinical, scientific trials about the practice of microdosing is pretty limited but James Fadiman and Jordan Gruber have collected what scientific m...
Feb 24, 2025•47 min•Ep. 198
Ophira Eisenberg once believed that everyone had a trauma quota, a maximum amount of hardship that a person would face in life and once that mark was hit, nothing bad would ever happen again. It was a way of comforting herself after a car accident at age eight that seriously injured Ophira and killed her friend. Turns out that’s not how life works and Ophira still had cancer and a miscarriage to deal with later on. Ophira joins us for a wise and actually very funny conversation about trauma, bei...
Feb 17, 2025•48 min•Ep. 197
Would you get a device the size of a Nilla wafer implanted in your body if it meant relief from treatment-resistant depression? There are big advances being made in vagal nerve stimulation therapy, a process by which electrical impulses are fed into a patient’s vagus nerve to alleviate depression that hasn’t responded to more common treatments. We take a look at the science, the breakthroughs, and why your insurance might be more likely to cover it. Then we have an interview with actor and write...
Feb 10, 2025•49 min•Ep. 196
The cover of Neko Case’s memoir features a young Neko in a swimsuit she says she wore for six months straight and she’s accompanied by a drawing of a big spiky-toothed monster who she says is there to protect her. The invention of such monsters can feel necessary when one’s parents are unavailable, simply not physically present, or, in the case of her mother, faking their own death only to reappear a year and a half later. Neko talks about the trauma of her childhood, what music meant then and a...
Feb 03, 2025•46 min•Ep. 195
Sex is not always an easy topic to discuss. Issues like how to get what you want, how to make sure your partner is getting what they want, these are delicate conversations and often intimidating ones as well. Add in issues like depression and anxiety for one or more of the people involved and it becomes more complex still. Fortunately, we have Dr. Emily Nagoski with us who is an expert on sex and how to talk about it. She’s the author of the new book, Come Together: The Science (and Art!) of Cre...
Jan 27, 2025•45 min•Ep. 194
Hari Kondabolu has never been afraid to talk about sensitive topics on stage. The veteran comedian, who has appeared on Conan, Kimmel, Letterman, and NPR’s Wait Wait... Don’t Tell Me mined material about race, immigration, and other societal hot button issues. But unlike some comedians, he was hesitant to discuss himself and in particular the depression that has followed him for years. He goes there in this interview that also includes exploration of panic attacks, the ups and downs of therapy, ...
Jan 20, 2025•53 min•Ep. 193
