Dr. Aneil Mallavarapu is leading Humain Ventures , an early stage venture capital firm focused on TechBio. We recorded a conversation together live in San Francisco with an all star audience of friends. At the intersection of biology and AI, there’s something game changing going on and TechBio aims to capture this. Aneil and his partner, 23andMe co-founder Linea Avey are both early pioneers in TechBio so learning from them is a real treat. Thanks a ton to Brady Forrest from Ignite for hosting th...
Sep 21, 2025•1 hr•Ep. 80
Dr. Eric Leuthardt is a top neurosurgeon. Professor at Washington University in St. Louis, he is also one of my favorite inventors. Years ago, we worked together at the Intellectual Ventures Lab on a helical brain surgery tool and origami patches for aneurysms. These days, he is the founder of Aurenar , which has developed a vegus nerve stimulation device that can keep people alive in the ICU. Deep Future is one of their first investors. More Resources Aurenar Website Tim Ferriss Podcast with Dr...
Aug 30, 2025•49 min•Ep. 79
CreateMe is pioneering robots to make clothes. Cam Myers is the founder and in this conversation, we get to pick apart all kinds of things about what they are doing to make this possible. About Cam Cam Myers is CEO and Founder of CreateMe, a company revolutionizing apparel manufacturing through automation and sustainable practices. Cam was born in New Zealand, and eventually moved to the United States in 2009 to pursue greater opportunities in the business world. He went on to found CreateMe in ...
Aug 16, 2025•1 hr 6 min•Ep. 77
Pablos makes the case for Computational Maximalism. Recorded on April 19, 2025 The post Jensen’s Law appeared first on .
Apr 21, 2025•15 min•Ep. 76
If you are any kind of deep tech founder, or an early stage, deep tech investor, this is a required episode. You need to know about Newlab . It’s one of the most special things in the entire deep tech ecosystem. Scott Cohen is one of the cofounders along with David Bell. They built this thing over the last decade or so in the Navy Yard in Brooklyn partly as a civic project. This is a place where hundreds of startups that are doing very difficult, very ambitious deep tech projects have gotten the...
Oct 05, 2024•1 hr 7 min•Ep. 75
Two nerds bullshitting about the cloak and dagger marketplace of raising a venture fund. Recorded on August 16, 2024 The post General Solicitation Rules for VC – ØF appeared first on .
Sep 24, 2024•11 min•Ep. 74
For 2,000 years, there’s been this incredible mystery in material science: how do the Romans build the Pantheon? It’s made of unreinforced concrete, in a seismic zone. After they built it, nobody’s been able to figure out how they did it for two millennia. Until last year when Admir Masic, scientist, professor at MIT showed the world, publishing in the journal Science , showing exactly how the Romans did that. Cement is the most used material on the entire planet. Between 8 and 13 percent of glo...
Sep 20, 2024•1 hr 27 min•Ep. 73
Two nerds bullshitting about the most important kitchen toy. Recorded on August 16, 2024 The post You Must Buy a Ninja Creami – ØF appeared first on .
Sep 16, 2024•6 min•Ep. 72
Avi Geiger is a super creative roboticist in Seattle, and I got a chance to sit down and pick his brain. He built a company called PicoBrew a little while ago after a career at Microsoft making hardware. PicoBrew was a way for people to do their own brewing at home, he built an entirely automated factory for it. I was always really impressed with the clever things he came up with. Now he has a company working on making robotics much more practical to integrate with AI, meaning how do you get the...
Sep 13, 2024•1 hr 34 min•Ep. 71
Two nerds bullshitting about how to jettison Google. Recorded on August 16, 2024 The post I’m a Perplexity Junkie – ØF appeared first on .
Sep 02, 2024•9 min•Ep. 70
Two nerds bullshitting about electric toys you can ride. Recorded on August 16, 2024 The post Electric Motortoys – ØF appeared first on .
Aug 26, 2024•18 min•Ep. 70
Two nerds bullshitting about the massive leak of social security numbers this week. Recorded on August 16, 2024 The post Mega SSN Leak – ØF appeared first on .
Aug 19, 2024•9 min•Ep. 68
The AESCAPE robot that gave me my first robomassage. One of the really important things to solve for is how do we get robots working much more closely with humans. And this is really difficult for a whole bunch of reasons, and you guys know some of them. But the truth is they need to be able to really get close. We need them to touch our bodies. And right now what we do with robots is we put them in giant cages and keep them away from the humans in case they need it. move at the wrong time. And ...
Aug 16, 2024•56 min•Ep. 67
Two nerds bullshitting about the imminent scale of computation on Earth. Recorded on July 5, 2024 The post NVIDIA Math – ØF appeared first on .
Aug 05, 2024•14 min•Ep. 66
Demonstration of Emergency Response technology, Bill Bob Brown visit to Wireless Test Bed When I was at the Idaho National Labs , I got to meet Wayne Austad. We had a conversation about cybersecurity as it relates to physical infrastructure. People always wonder what if hackers shut down the power grid? They have shut down the power grid, in different parts of the world and we talked about that a little bit. Wayne’s at the forefront of figuring out how do we secure this physical stuff? How do we...
Aug 02, 20240•Ep. 65
Two nerds bullshitting about turning your dead relatives into diamonds.. Recorded on July 7, 2024 The post Cremation Diamonds – ØF appeared first on .
Jul 29, 2024•4 min•Ep. 64
One of the awesome guys that got to meet at the Idaho National Labs is Nicholas Woolstenhulme. He’s a mechanical engineer working on the fuel for nuclear reactors, and his whole career has been working on the fuel for nuclear reactors. He gets to learn about all the fuels that are possible to make, test them out, figure out how to make them better, make them safer, make them more efficient. In this conversation, we dig into that. He brought me an amazing example of a 3d printed model of how fuel...
Jul 25, 2024•29 min•Ep. 63
Two nerds and an Australian architect bullshitting about turning CAD software into a giant world simulating video game. Recorded on July 5, 2024 The post CAD World Game – ØF appeared first on .
Jul 22, 2024•10 min•Ep. 62
Recently, I got to go hang out at the Idaho National Labs in Idaho Falls. There are thousands of people at those labs, working on the future of energy for the United States. They’re working on renewable energy of course. They’re working on all kinds of things that I had no idea were happening. Around recycling and waste processing, but primarily they are working on nuclear reactors. It was such a treat for me to go see all the work they’re doing. We have engineers who spent their entire careers ...
Jul 18, 2024•18 min•Ep. 61
Two nerds bullshitting about alternatives to college that would provide some of the same benefits. Recorded on July 7, 2024 The post College Experience Alternatives – ØF appeared first on .
Jul 15, 2024•21 min•Ep. 60
Frank Rieger is a hacker in Germany and one of the most well-known spokesman for the chaos computer club. This organization is unlike anything we have in the United States, unlike anything I’ve seen anywhere else in the world. It’s computer hackers who’ve taken an interest in figuring out how to be activists for policy decisions in government that affect technology, especially computers, privacy, data. All the things that actually matter, but get thrown by the wayside by our corporate overlords....
Jul 11, 2024•1 hr 22 min•Ep. 59
Two nerds bullshitting about LinkedIn basically being Dungeons & Dragons for squares. Recorded on July 5, 2024 The post LinkedIn is D＆D – ØF appeared first on .
Jul 08, 2024•11 min•Ep. 58
Two nerds bullshitting about robots that can give a good massage. Recorded on May 15, 2024 The post Massagebot 5000 Part I – ØF appeared first on .
Jun 18, 2024•10 min•Ep. 48
I got to hang out with Dr. Bruce Damer recently on the beach at Kaplankaya in Turkey. Bruce is an amazing scientist, a humble guy. Who has spent his whole career trying to figure out how did life begin on Earth? He and his co-conspirator Dr. David Deamer have figured out something that not only works as a hypothesis for how life began on Earth – but they’ve been able to reproduce it – in hot Springs. Bruce is also a brave pioneer of using psychedelics to change his own mind, to change his own li...
Jun 13, 2024•1 hr 5 min•Ep. 54
Two nerds bullshitting about making amino acid Legos that kids can plug together to make proteins. This turned into a completely unrelated conversation about delivering personalized pharmaceuticals. Recorded on May 15, 2024 The post Amino Acid Anal Bead Toy for Kids – ØF appeared first on .
Jun 10, 2024•12 min•Ep. 53
Robert Green is a professor of genetics at Harvard Medical School. He’s the director of Genetics Research at Brigham and Women’s hospital and the co-founder of Nurture Genomics , where they’re doing genomic screening for infants to detect and mitigate actionable genetic conditions. If you don’t understand what that means, you’re in the right place because we have a long conversation, digging into that topic and picking it apart for your understanding. Robert Green and Pablos This is a super exci...
Jun 06, 2024•1 hr 1 min•Ep. 52
Two nerds bullshitting about feeding the output from one industrial process as the input for another. Recorded on May 15, 2024 The post Industrial Ouroboros – ØF appeared first on .
Jun 03, 2024•10 min•Ep. 51
Dan Shapiro with his game Robot Turtles. Photo by Jonathan H. Liu I met Dan Shapiro years ago when I went out to fly kites with Elan Lee . What a delightful guy! Dan is an inspiring entrepreneur with boundless energy, always upbeat. He’s had, I think, four companies that succeeded, maybe three that were venture backed. Dan did something super cool. He got excited about making a board game that would teach kids how to program called Robot Turtles. He made that game using Kickstarter or something,...
May 30, 2024•1 hr 25 min•Ep. 50
Two nerds bullshitting about using X-PRIZE and Kickstarter to get nuclear reactors built. Recorded on May 15, 2024 The post Nuclear Reactor Kickstarter – ØF appeared first on .
May 27, 2024•21 min•Ep. 49
Two nerds bullshitting about their search for the ultimate black t-shirt. We tried shirts from Vollebak , Ministry of Supply , ETON , Wyr . Recorded on March 13, 2024 The post Black T-Shirt Review – ØF appeared first on ....
May 23, 2024•10 min•Ep. 48
