In this episode, Timothy J. Wilkin, MD, MPH, provides a case-based overview of switching antiretroviral therapy in a patient with viral suppression on their current regimen who has a history of virologic failure with drug-resistance mutations. Key findings from 2 relevant studies—the SWITCHMRK trial and Study 380-4030—are reviewed. The case discussion also highlights several other challenges that can be encountered in the switch setting, including incomplete immune recovery, comorbidities, and g...
Oct 20, 2022•7 min•Ep. 202
In this episode, Tristan J. Barber, MA, MD, FRCP, and Darcy Wooten, MD, discuss switching ART with virologic suppression, including: Switching with prior or unknown resistance Data on switching to BIC/FTC/TAF with a preexisting M184V/I mutation from a pooled analysis of 6 phase III studies The impact of baseline resistance on outcomes following a switch to BIC/FTC/TAF in Black PWH from the BRAAVE 2020 study A post hoc analysis of the SALSA study of DTG/3TC outcomes at Week 48 by baseline resista...
Oct 19, 2022•57 min•Ep. 201
In this episode, Lilian Abbo, MD, FIDSA; Julie Ann Justo, PharmD, MS; and David van Duin, MD, PhD, FIDSA, FAST, discuss key concepts about extraintestinal pathogenic Escherichia coli , including: Diverse strains and virulence factors associated with invasive disease Antimicrobial resistance profiles seen in clinical practice Various disease manifestations Prevalence and burden of invasive infections Populations at risk Risk factors for multidrug-resistant strains Emerging vaccine technologies Ac...
Oct 18, 2022•1 hr 19 min•Ep. 200
In this podcast, Gary S. Marshall, MD, summarizes the burden of meningococcal disease and the importance of immunization, including: The unpredictability and severity of meningococcal disease Differences between meningococcal serogroups and available vaccines Current meningococcal vaccine recommendations, distinguishing between routine vs shared clinical decision-making recommendations Vaccine recommendations in high-risk populations Use of immunization platforms to help complete age-appropriate...
Oct 12, 2022•13 min•Ep. 199
In this episode, Cristina Mussini, MD, shares her approach to caring for aging patients with HIV. This includes not just focusing on their HIV, but their over well-being, such as: Maintaining a healthy weight, eating healthy and staying mobile Overcoming the obstacle of stigma from society and self-stigma Empowering patients to care for themselves In women who are often caregivers most of their life: Encouraging self-care Staying up to date with preventive care such as cancer screenings (eg, mam...
Oct 12, 2022•9 min•Ep. 198
How do we define “older” in our older patients living with hepatitis B virus (HBV)? What monitoring and treatment options should be considered for these older patients with chronic HBV infection? Listen as Nancy Reau, MD, discusses strategies and considerations for monitoring and treating older adults with HBV, illustrated with a patient case. Presenter: Nancy Reau, MD Professor of Medicine Chief , Section of Hepatology Associate Director , Solid Organ Transplantation Richard B. Capps Chair of H...
Oct 10, 2022•9 min•Ep. 197
In this episode, listen to Priscilla Y. Hsue, MD, and Jens D. Lundgren MD, DMSc, discuss the latest data about ARV-related weight gain and cardiometabolic toxicities in PWH. Hear faculty: Review risk factors associated with significant weight gain Consider possible implications of weight gain and cardiometabolic toxicities Share their approaches to ARV-related weight gain and/or cardiometabolic toxicities Faculty: Priscilla Y. Hsue, MD Professor of Medicine University of California at San Franci...
Oct 04, 2022•22 min•Ep. 196
In this episode, Chloe Orkin, MBChB, FRCP, MD, discusses new HIV data from AIDS 2022, including: Prevention strategies Oral therapies LA therapies Cure COVID-19 in PWH Faculty Chloe Orkin, MBChB, FRCP, MD Professor of HIV Queen Mary, University of London Consultant Physician Lead for HIV Research Barts Health NHS Trust The Royal London Hospital London, United Kingdom Follow along with the slides at bit.ly/3SLuhBq Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about...
Oct 04, 2022•36 min•Ep. 193
In this episode, Roger Bedimo, MD, MS, FACP, discusses key considerations for switching ART in virologically suppressed patients who are pregnant or trying to conceive. His discussion includes: DHHS Perinatal Guideline recommendations French Perinatal Cohort study on the implications of viral suppression when changing ART in the first trimester of pregnancy IMPAACT 2010 Update on the safety and efficacy of DTG vs EFV and TDF vs TAF in pregnancy DolPHIN-2 study of virological suppression with DTG...
Oct 03, 2022•12 min•Ep. 194
In this podcast, Melanie Reese, a woman aging with HIV, shares her perspectives on the added challenges faced by older women with HIV—an underserved, underresourced, and underresearched group—and talks about potential solutions that should be considered, such as: Listen and prioritize concerns brought to you by older women with HIV to improve trust in you and the medical profession Promote self-advocacy for women to improve their interactions with healthcare professionals, such as opening the di...
Sep 29, 2022•23 min•Ep. 192
In this episode, listen to Dorothy Onyango, patient and patient activist, share her views on the many barriers encountered by aging patients with HIV living in resource-limited settings and the need to work on solutions to overcome such barriers, including: The major burden of poverty affecting access to care/medications, healthcare services (eg, treatment for noncommunicable diseases, home-based care), and social support The added social obstructions to HIV care for older women (eg, sexual repr...
Sep 20, 2022•18 min•Ep. 191
In this episode, an international expert panel shares their thoughts on key considerations for incorporating long-acting cabotegravir as an additional HIV pre-exposure prophylaxis option for appropriate individuals at high risk of acquiring HIV infection. Topics include anticipated patient interest in this new paradigm, the role of the oral lead-in phase, new guideline recommendations for monitoring during PrEP, patient care and follow-up after PrEP discontinuation, and remaining unanswered ques...
Sep 08, 2022•21 min•Ep. 190
In this podcast, Jonathan Appelbaum, MD, FACP, AAHIVS, summarizes the many medical challenges faced by aging people with HIV, including: Underrepresentation of older patients in medical research Consequences of early experiences in the epidemic such as late HIV diagnosis and low CD4+ cell count nadir, incomplete or short-lived virologic suppression with early regimens, and toxicity associated with early antiretroviral agents Added challenges of multimorbidity and psychosocial challenges, especia...
Aug 25, 2022•13 min•Ep. 189
In this episode, Babafemi Taiwo, MBBS, discusses strategies for reaching people with HIV who are not yet diagnosed. His overview includes: HIV diagnosis by global region Disparities in serostatus awareness Patient perspective on importance of HIV testing Barriers to HIV diagnosis Complications from late HIV diagnosis Strategies to improve rates of HIV testing Presenter: Babafemi Taiwo, MBBS Gene Stollerman Professor of Medicine Chief , Division of Infectious Diseases Northwestern University F...
Aug 24, 2022•15 min•Ep. 186
In this episode, Chloe Orkin, MBChB, FRCP, MD, discusses strategies for successful antiretroviral therapy (ART) initiation. Her overview includes: Recommendations for rapid ART First-line ART regimens for treatment-naive people with HIV IMEA 055 FAST study STAT study DIAMOND study Antiretroviral resistance mutations Patient perspectives on the importance of rapid ART initiation Presenter: Chloe Orkin, MBChB, FRCP, MD Professor of HIV Queen Mary, University of London Consultant Physician Lead ...
Aug 24, 2022•16 min•Ep. 188
In this episode, Nagalingeswaran Kumarasamy, MBBS, FRCP, PhD, discusses the importance of linking people to care after a positive HIV diagnosis. His overview includes: HIV care continuum Factors that delay linkage to care Organized strategies to improve linkage to care for people with HIV Interventions that may improve linkage to care for people with HIV Patient perspective on how to engage patients in their HIV care Presenter: Nagalingeswaran Kumarasamy, MBBS, FRCP, PhD Chief and Director VHS ...
Aug 24, 2022•12 min•Ep. 187
In this episode, hear Dr. Jean Rene Anderson and Dr. William Short discuss special factors to consider when selecting HIV treatments during pregnancy, including: Key elements involved in evaluating ARV medications during pregnancy (eg, efficacy, pharmacokinetic, and safety data) Approach to optimizing ART regimens prior to and during pregnancy Faculty: Jean Rene Anderson, MD Professor Department of Gynecology and Obstetrics Johns Hopkins University Director, Johns Hopkins HIV Women's Health Prog...
Aug 23, 2022•15 min•Ep. 185
You can think of the “D” in HDV as standing for difficult, disadvantaged, and dangerous. Hepatitis delta virus (HDV) is difficult to diagnose, is often diagnosed in disadvantaged patient populations, and leads to dangerous sequelae. Listen as Dr. Kosh Agarwal and Dr. Graham R. Foster and discuss challenges and opportunities for linking patients to care after a positive test for HDV. Presenters: Kosh Agarwal, MD Consultant Hepatologist and Transplant Physician Institute of Liver Studies King's Co...
Aug 03, 2022•23 min•Ep. 172
In this episode, an international expert panel shares their thoughts on key considerations at the operational level for incorporating long-acting injectable antiretroviral therapy into the HIV treatment armamentarium. Topics include the duration of injection appointments in real-world settings, managing additional patient volume/workload (particularly the key role of nurses), and preventing and addressing planned and unplanned missed doses. Other episodes in this 4-part series cover additional a...
Aug 02, 2022•13 min•Ep. 184
In this episode, an international expert panel shares their thoughts on key steps for switching patients to long-acting injectable cabotegravir plus rilpivirine for HIV treatment, including selecting the most appropriate patients, introducing patients to the long-acting option, and preparing patients for what to expect from long-acting treatment in terms of efficacy, visit timing, and the injection experience. Subsequent episodes in this 4-part series will cover additional aspects of long-acting...
Jul 14, 2022•17 min•Ep. 183
In this episode, hear HIV activist Marc Thompson share his perspectives on aging with HIV including: His early experiences after receiving his diagnosis Persisting issues of the HIV epidemic including stigma and discrimination Changes in healthcare with the advent of HIV treatment Added issues of aging with HIV like polypharmacy, multimorbidity, and mental health concerns (eg, loneliness, social isolation) Actions needed to improve the path for the future: addressing opportunities to expand rese...
Jul 06, 2022•11 min•Ep. 182
In this episode, Stefan Zeuzem, MD, discusses new viral hepatitis data from EASL 2022, including: Novel HBV therapeutics, including the REEF-2, B-Clear, and SAVE-1 studies HBV cure from the Everest Project in China HDV therapeutics from MYR301 and a study of bulevirtide in patients with cirrhosis and portal hypertension HCV retreatment in patients with prior direct-acting antiviral therapy failure Presenter: Stefan Zeuzem, MD Professor of Medicine Chief , Department of Medicine I JW Goethe Unive...
Jul 06, 2022•37 min•Ep. 181
In this episode, Nancy Reau, MD, discusses new viral hepatitis data from EASL 2022, including: Novel therapeutics for HBV Therapeutic vaccination for HBV Emerging treatment options for HDV HCV care cascade HCC monitoring after HCV cure Presenter: Nancy Reau, MD Professor of Medicine Chief , Section of Hepatology Associate Director , Solid Organ Transplantation Richard B. Capps Chair of Hepatology Rush University Medical Center Chicago, Illinois Follow along with the downloadable slideset at: htt...
Jul 05, 2022•7 min•Ep. 180
In this episode, Carla S. Coffin, MD, MSc, shares her thoughts on the different investigational approaches under evaluation for their potential to achieve HBV cure, including entry inhibitors, capsid inhibitors, siRNAs, immune modulators, TLR agonists, therapeutic vaccines, and checkpoint inhibitors. Presenter: Carla S. Coffin, MD, MSc Professor of Medicine Division of Gastroenterology and Hepatology Department of Medicine University of Calgary Medical Director of Calgary Liver Unit Division of ...
Jun 30, 2022•15 min•Ep. 179
In this episode, Yvette Raphael provides her perspectives and advice as an individual living with HIV in South Africa for more than 20 years. She shares her experiences and ideas for how to improve processes related to HIV diagnosis, care linkage, and treatment. Presenter: Yvette Raphael Content based on an online CME program supported by an independent educational grant from Gilead Sciences, Inc. Link to full program: https://bit.ly/3tmgozy Hosted by Simplecast, an AdsWizz company. See pcm.adsw...
Jun 21, 2022•12 min•Ep. 178
In this episode, Pietro Lampertico, MD, PhD, discusses what to do when treatment for hepatitis B virus (HBV) infection is not indicated, covering topics such as: The different phases of chronic HBV infection Which patients in different phases require immediate HBV treatment and which can be monitored without therapy The critical importance of ongoing monitoring for patients who do not meet indications for immediate therapy The tests and frequency that should be used for monitoring patients not r...
May 26, 2022•14 min•Ep. 177
In this episode, Michelle D. Collins-Ogle, MD, FAAP, FPIDS, AAHIVS, explores the data and recommendations for HIV postexposure prophylaxis (PEP). Listen as she gives perspectives on: The CDC algorithm for evaluation and treatment of potential HIV exposures The CDC guideline preferred and alternative PEP antiretroviral therapy regimens Data for the use of the single-tablet regimen bictegravir/emtricitabine/tenofovir alafenamide for PEP Recommended laboratory monitoring with PEP The initiation of ...
May 26, 2022•25 min•Ep. 176
In this episode, Michelle D. Collins-Ogle, MD, FAAP, FPIDS, AAHIVS, explores key considerations for choosing antiretroviral therapy (ART) for pediatric patients. Listen as she gives perspectives on: Department of Health and Human Services (DHHS) guideline recommendations for infants at risk for perinatal HIV transmission DHHS guideline–recommended ART regimens for children The ODYSSEY A and B studies evaluating dolutegravir-based ART in children and adolescents Data for the use of the fixed-dose...
May 25, 2022•21 min•Ep. 175
In this episode, Michelle D. Collins-Ogle, MD, FAAP, FPIDS, AAHIVS, explores key considerations for transgender people with HIV (PWH). Listen as she gives perspectives on: Department of Health and Human Services (DHHS) guideline recommendations for transgender PWH Providing HIV care within a gender-affirmative care model, including discussion of strategies, barriers, and facilitators Gender-affirmative hormone therapy options Drug–drug interaction potential between gender-affirmative hormone the...
May 25, 2022•28 min•Ep. 174
In this episode, Sharon R. Lewin, AO, FRACP, PhD, FAHMS, discusses: Principles for antiviral agent use in nonhospitalized patients Preferred and alternative treatment options Treatment prioritization when there are logistical or supply constraints Outpatient remdesivir use PINETREE data (adult patients) CARAVAN data (pediatric patients) FDA approval and treatment candidacy Therapeutic updates Ivermectin and the TOGETHER study Monoclonal antibody use during current omicron era Presenter: Sharon R...
May 24, 2022•35 min•Ep. 173
