In this episode, Renslow Sherer, MD, discusses key data on COVID-19 vaccine efficacy, including: Third doses Booster doses Mixing and matching booster doses Presenter: Renslow Sherer, MD Director , International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Health Department of Medicine University of Chicago Chicago, Illinois Review the downloadable slideset at: https://bit.ly/3Fl0yZV Link to full program: https://bit.ly/3EH2485 Hosted by Simplecast, an AdsW...
Dec 10, 2021•40 min•Ep. 110
In this episode, Martin C. Mahoney, MD, PhD, discusses new data on vaccine-preventable diseases from IDWeek 2021, including: Pneumococcal disease Respiratory syncytial virus (RSV) Herpes zoster Influenza Presenter: Martin C. Mahoney, MD, PhD Professor of Oncology Department of Internal Medicine Roswell Park Comprehensive Cancer Institute Buffalo, New York Follow along with an expanded slideset at: https://bit.ly/3Ev8ozr Link to full program: https://bit.ly/3BCHF2E Hosted by Simplecast, an AdsWiz...
Dec 06, 2021•39 min•Ep. 109
In this episode, Nancy Reau, MD, discusses new viral hepatitis data from AASLD 2021, including: HBV treatment in pregnancy Outcomes following HBV treatment withdrawal Progress toward an HBV cure HCV implementation science and current status of the cascade of care Hepatitis delta virus: understanding the clinical impact Phase III clinical trial updates for hepatitis delta virus, including data on bulevirtide Presenter: Nancy Reau, MD Professor of Medicine Chief , Section of Hepatology Associate D...
Dec 01, 2021•39 min•Ep. 108
In this episode, Tristan J. Barber, MA, MD, FRCP, discusses new HIV data from EACS 2021, including: First-line therapies BIC/FTC/TAF in a test-and-treat model in IMEA 055 FAST Week 144 data of ISL + DOR in treatment-naive patients from P011 Switch Strategies Data on the use of DTG/3TC in patients with an M184V mutation from SOLAR 3D and the French Dat’AIDS Cohort Long-Acting Therapies Efficacy and safety of LA CAB + RPV by BMI Long-term follow-up of participants who discontinued LA CAB + RPV in ...
Nov 30, 2021•36 min•Ep. 107
In this episode, Dalilah Restrepo, MD, discusses expert guidance on vaccination for the prevention of shingles complications in the COVID-19 era. Contributor: Dalilah Restrepo, MD Infectious Diseases Specialist Fountain Valley Hospital Fountain Valley, California Using a case study and the latest expert guidance, this podcast covers topics such as: Expert guidance on maintenance of routine vaccination during the COVID-19 era Common shingles complications in immunocompetent patients Additional sh...
Nov 23, 2021•15 min•Ep. 106
In this episode, William R. Short, MD, MPH, AAHIVS, explores recommendations and data on strategies to address suboptimal CD4+ cell count response in people with HIV on suppressive ART. Listen as he gives his perspectives on: The consequences of suboptimal CD4+ cell count response ART intensification ART switch strategies with data from the SPIRAL study Data on the addition of interleukin-2 from the SILCAAT and ESPIRIT studies DHHS guideline recommendations Presenter: William R. Short, MD, MPH, ...
Nov 19, 2021•11 min•Ep. 105
In this episode, Prof Ashley Brown, BSc, MD, FRCP, and Ahmed M. Elsharkawy, PhD, FRCP(UK), discuss key racial inequities of care that lead to undertreatment for migrant populations and other racial minorities globally with or at risk for hepatitis C. Topics include: HCV Burden and Care Disparities in Specific Populations Genotypes and Length of Infection in Ethnic Minorities Primary Care Education and System-Related Barriers Solutions to Overcome Barriers to HCV Care First-hand Patient Stories P...
Nov 17, 2021•40 min•Ep. 104
In this episode, Fidelia Bernice, PharmD, and Aadia I. Rana, MD, share insights on HIV ART safety and tolerability including recent data on nephrotoxicity and the use of NRTI-sparing regimens with discussion of the GEMINI-1 and -2 studies of DTG/3TC and the SWORD-1 and -2 studies of DTG/RPV, and safety with long-acting injectables with specific discussion of the ATLAS and FLAIR studies of LA CAB plus RPV and the CUSTOMIZE study. Presenters: Fidelia Bernice, PharmD Clinical Pharmacy Specialist In...
Nov 16, 2021•40 min•Ep. 103
In this episode, Tracy Zivin-Tutela, MD, discusses expert guidance on vaccination against shingles. Tracy Zivin-Tutela, MD Infectious Diseases Specialist Department of Infectious Diseases Fountain Valley Regional Hospital Los Alamitos Medical Center Fountain Valley, California Using a case study and the latest expert guidance, this podcast covers topics such as: Counseling patients on benefits and efficacy of vaccination against shingles Vaccine safety Vaccination guidelines for adults with or w...
Nov 11, 2021•11 min•Ep. 102
In this episode, William R. Short, MD, MPH, AAHIVS, explores recommendations and data on switching to 2-drug single-tablet ART regimens. Listen as he gives his perspectives on: Indications for the available 2-drug single-tablet regimens: DTG/RPV and DTG/3TC The SWORD-1 and SWORD-2 studies evaluating switching to DTG/RPV in virologically suppressed patients Real-world experience with switching to DTG/RPV from the OPERA study The TANGO study evaluating switching to DTG/3TC from a stable TAF-based ...
Nov 10, 2021•18 min•Ep. 101
In this episode, Gregory Dore, MBBS, PhD, FRACP, MPH, and Stacey Trooskin, MD, PhD, MPH, share lessons learned in the care of patients with HCV infection during the COVID-19 pandemic, including: Telehealth Treatment of PWID TEMPO pilot study MINMON study Presenters: Gregory Dore, MBBS, PhD, FRACP, MPH Professor, Head Viral Hepatitis Clinical Research Program Kirby Institute University of New South Wales Infectious Diseases Physician St. Vincent's Hospital Sydney, Australia Stacey Trooskin, MD, P...
Nov 10, 2021•24 min•Ep. 100
In this episode, hepatologist Giada Sebastiani, MD, discusses why the presence of obesity, metabolic syndrome, persistent elevation of ALT, or exposure to dideoxynucleoside analogues can trigger an evaluation for NAFLD and NASH, particularly in our aging population of patients with HIV with topics including: Metabolic factors HIV-related factors Which patients with HIV are at risk Presenter: Giada Sebastiani, MD Associate Professor of Medicine McGill University Health Centre Division of Gastroen...
Nov 10, 2021•7 min•Ep. 58
In this episode from the series “Key Decisions in HIV Care,” Milena Murray, PharmD, MSc, BCIDP, AAHIVP, and Jonah Musa, MBBS, MSCI, PhD, discuss important considerations for ART use in pregnancy, including DHHS and WHO guideline recommendations and data supporting recommended ART regimen options in pregnancy from IMPAACT 2010, Tsepamo, and DoLPHIN-2. They also discuss pharmacokinetic considerations and drug–drug interactions. Following their dialogue, the faculty field questions from healthcare ...
Nov 08, 2021•43 min•Ep. 99
In this episode, Renslow Sherer, MD, discusses new COVID-19 data from IDWeek 2021, including: Prevention of COVID-19 ChAdOx1 nCoV-19 Ad26.COV2.S Tixagevimab plus cilgavimab Outpatients with COVID-19 Remdesivir IV Molnupiravir Hospitalized patients with COVID-19 Baricitinib Lenzilumab Casirivimab plus imdevimab Long-term COVID-19 outcomes Sustained recovery Presenter: Renslow Sherer, MD Director International HIV Training Center Professor of Medicine Section of Infectious Diseases and Global Heal...
Oct 29, 2021•56 min•Ep. 97
In this episode, Oni Blackstock, MD, MHS, and Nina T. Harawa, PhD, MPH, discuss racial disparities in COVID-19 outcomes, including: Background on healthcare inequities among BIPOC COVID-19 racial disparities and the healthcare inequities driving them Overcoming barriers to optimal COVID-19 care among BIPOC Addressing concerns about COVID-19 vaccination Motivational interviewing principles and the brief negotiated interview to earn trust and increase vaccine acceptance Presenters: Oni Blackstock,...
Oct 29, 2021•39 min•Ep. 98
In this episode, Nicholas Chamberlain, MD, provides an overview of the different antiretroviral drug formulations and dosing strategies in various stages of clinical development for long-acting HIV PrEP—advances that collectively offer the potential for highly individualized approaches to HIV biomedical prevention. Presenter: Nicholas Chamberlain, MD Medical Director AHF Healthcare Center – Atlanta Midtown Department of Medicine AIDS Healthcare Foundation Atlanta, Georgia Content based on an onl...
Oct 21, 2021•18 min•Ep. 96
In episode 1 of an ongoing series of conversations between a physician and patient, Stacey Trooskin, MD, PhD, MPH, and patient advocate Brother Dan Palmer discuss approaches to improve access to HCV therapy. The conversation focuses on how barriers to care affected Dan’s health after his hepatitis C diagnosis and the strategies he employed to overcome them. Presenter: Stacey Trooskin, MD, PhD, MPH Chief Medical Officer Philadelphia FIGHT Community Health Centers Faculty Division of Infectious Di...
Oct 19, 2021•18 min•Ep. 95
In this podcast episode, Paul E. Sax, MD, and Renslow Sherer, MD, discuss the clinical significance of new data on the prevention and treatment of COVID-19, including: COVID-19 in immunocompromised hosts Prime-Boost Strategy for COVID-19 vaccination COVID-19 surge effects Monoclonal antibody therapy for prevention and treatment Remdesivir update Repurposed drug, fluvoxamine What does the future of the pandemic look like? Presenters: Paul E. Sax, MD Clinical Director HIV Program and Division of I...
Oct 14, 2021•42 min•Ep. 94
In this episode, Milena Murray, PharmD, MSc, BCIDP, AAHIVP, explores recommendations and data to support the management of missed CAB plus RPV injections. Listen as she gives her perspectives on: Prescribing information recommendations for managing missed injections of CAB plus RPV Pharmacokinetic modeling data to support management strategies for missed injections Data from the ATLAS and FLAIR studies on missed injections and patient outcomes Presenter: Milena Murray, PharmD, MSc, BCIDP, AAHIVP...
Oct 13, 2021•10 min•Ep. 93
In this episode, Milena Murray, PharmD, MSc, BCIDP, AAHIVP, explores recommendations and data on maternal weight gain associated with ART use in pregnancy. Listen as she gives her perspectives on: IMPAACT 2010 data on maternal weight gain with DTG + FTC/TAF vs DTG + FTC/TDF vs EFV/FTC/TDF SMARTT study data on gestational weight gain by ART class Tsepamo Surveillance study data on maternal weight and birth outcomes among women receiving ART, as well as weight outcomes with DTG vs EFV DHHS Perinat...
Oct 12, 2021•11 min•Ep. 92
In this episode, Darcy Wooten, MD, discusses new HIV data from IDWeek 2021, including: A rapid test-and-treat program to start DTG/3TC in patients newly diagnosed with HIV (STAT) Efficacy when switching from 3-drug to 4-drug TAF-based regimens to DTG/3TC (TANGO) Virologic outcomes with 2-drug vs 3-drug ART regimens (Trio Health HIV Network Study) Metabolic complications in treatment-naive patients (Study 1489 and Study 1490) Resistance analysis of an investigational agent, lenacapavir (CALIBRATE...
Oct 11, 2021•42 min•Ep. 91
During this episode, Lynora Saxinger, MD, FRCPC, CTropMed, updates listeners on the latest Emergency Use Authorizations and guideline recommendations for optimal clinical management of COVID-19. Gain practical insights on patient identification, risk stratification, and treatment. Key points include: Treatment of COVID-19 can be broken into antiviral and immune-modulating therapies Each agent should be used at the correct disease stage to maximize benefit Antiviral medications and mAbs show the ...
Oct 11, 2021•44 min•Ep. 90
In this episode from the series “Key Decisions in HIV Care,” Jason Halperin, MD, MPH, and Jürgen K. Rockstroh, MD, discuss important considerations in the rapid initiation of ART, including guideline recommendations and data supporting recommended ART regimen options for rapid initiation and emerging data for the 2-drug regimen dolutegravir/lamivudine for rapid start from the STAT study. Following their dialogue, the faculty field questions from healthcare professionals. Presenters: Jason Halper...
Sep 29, 2021•41 min•Ep. 88
In this episode, Milena Murray, PharmD, MSc, BCIDP, AAHIVP, explores the data to support the use of tenofovir alafenamide in pregnancy. Listen as she gives her perspectives on: DHHS guideline recommendations for the use of TAF in pregnancy Pharmacokinetic data to support adequate TAF concentrations throughout pregnancy Available antiretroviral pregnancy registry information on the use of TAF in pregnancy Data from the IMPAACT 2010 study to support the use of a TAF-containing regimen in pregnancy...
Sep 29, 2021•10 min•Ep. 89
In this episode, Tracy Zivin-Tutela, MD, discusses factors that put your patients at risk for shingles and its complications. Tracy Zivin-Tutela, MD Infectious Diseases Specialist Department of Infectious Diseases Fountain Valley Regional Hospital Los Alamitos Medical Center Fountain Valley, California Using a case study and the latest data, this podcast covers topics such as: Pathophysiology and epidemiology Disease burden and potential complications in older patients, including postherpetic ne...
Sep 24, 2021•8 min•Ep. 87
In this episode, Jason Halperin, MD, MPH, explores the data to support rapid ART initiation in adolescent patients. Listen as he gives his perspectives on: DHHS and IAS-USA guidelines for rapid initiation and specific recommendations for adolescents and young adults CrescentCare data comparing the virologic outcomes for patients 18-24 years of age compared with those aged 25 years or older Data to suggest that rapid ART upholds equity In addition, hear his patient’s perspective on the importance...
Sep 23, 2021•12 min•Ep. 85
In this episode, Jason Halperin, MD, MPH, explores the data to support rapid ART initiation in patients with OUD. Listen as he gives his perspectives on: DHHS guidelines for rapid initiation of ART and specific recommendations for patients with substance use disorders SAMSHA recommendations for the treatment of OUD Medications that are recommended for the treatment of OUD, including drug–drug interaction considerations with ART Data to support the treatment of OUD to improve HIV viral suppressio...
Sep 23, 2021•12 min•Ep. 86
In this episode, Colleen Kelley, MD, MPH, discusseskey features and available safety and efficacy data on investigational long-acting HIV pre-exposure prophylaxis strategies that are in late stages of clinical development. Presenter: Colleen Kelley, MD, MPH Atlanta, Georgia Colleen Kelley, MD, MPH, has disclosed that she has received funds for research support from Gilead Sciences, Moderna, Novavax, and ViiV Healthcare. Content based on an online CME program supported by an independent education...
Sep 16, 2021•15 min•Ep. 84
In this second of 2 episodes, Shobha Swaminathan, MD, and Eric S. Daar, MD, review key data influencing their practice following the IAS 2021 Conference, including data on investigational antiretroviral agents, lenacapavir and islatravir, and alternative dosing of BPaL for MDR-TB. This episode includes discussion of: An extension of FLAIR, demonstrating virologic efficacy and safety of long-acting CAB plus RPV at Week 124 A Week 26 safety and efficacy analysis of CAPELLA, a study of lenacapavir ...
Sep 14, 2021•42 min•Ep. 83
In this podcast episode, Sharon R. Lewin, AO, FRACP, PhD, FAHMS, and Arthur Kim, MD, discuss data on the potential use of monoclonal antibodies (mAb) for the prevention and treatment of COVID-19, including: Rationale for use of mAb Potential for resistance to mAb Single vs combination therapy with mAb Challenges in implementation of mAb as treatment or prevention Bamlanivimab Sotrovimab Casirivimab plus imdevimab Link to full program, including downloadable slidesets: https://bit.ly/3zVTwYW Pres...
Sep 14, 2021•43 min•Ep. 80
