This week, please join author Sreekanth Vemulapalli as he discusses the article "Adaptive AI for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the ODYSSEY OUTCOMES and EUCLID Trials." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260601.995930...
This week, please join author Harmony R. Reynolds and Associate Editor Nicholas Mills as they discuss the article " Multimodality Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women and Men." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260526.732262...
This week, please join author Nicholas A. Marston and Section Editor Parag Joshi as they discuss the article "Effect of APOC3 Inhibition With Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260518.156242...
This week, please join author Jean-Luc Vachiery and Associate Editor Kelly Chin as they discuss the article "Sotatercept for Combined Post- and Precapillary Pulmonary Hypertension Associated With Heart Failure: Results From the Phase 2, Randomized, Placebo-controlled CADENCE Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260511.411136...
This week, please join authors Gregory D. Lewis and Ravi V. Shah as they discuss the article "Multiorgan Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure With Preserved Ejection Fraction." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260504.789757...
This week, please join Chair Roger Blumenthal and author Gregg Fonarow as they discuss the recently published "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" along with an accompanying commentary "The 2026 American College of Cardiology/American Heart Association Multisociety Guideline on the Management of Dyslipidemia: A More Precise—But More Complicated—Framework for Atherosclerotic Cardiovascular Disease Prevention and Treatment." For the ...
This week, please join author Alexander "Sasha" Opotowsky as he discusses the article "The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260420.342132...
This week, please join author Edouard L. Fu and Associate Editor Dhruv Kazi as they discuss the article "Risk of Heart Failure Hospitalization for GLP-1 Receptor Agonists Versus DPP-4 Inhibitors or SGLT-2 Inhibitors in Patients With Type 2 Diabetes: A Target Trial Emulation." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260413.101706...
This week, please join author Rik Pauwels as he discusses the article "Wearable-Derived Training Load and Coronary Atherosclerosis in Middle-Aged and Older Athletes and Physically Active Controls: A New Perspective From the Master@Heart Study." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260406.965700...
This week, please join authors Charles Khouri and Clément Jambon-Barbara as well as Associate Editor Kelly Chin as they discuss the article "Second- and Third-Generation BCR-ABL Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260330.77255...
This week, please join author Ivo Roca-Luque and Editorialist Andrew Arai as they discuss the article "PAM-VT 2 Study: Long-Term Scar Evolution and Ablation Lesion Assessment by Late Gadolinium Enhancement Cardiac Magnetic Resonance After Ventricular Tachycardia Ablation" and the accompanying editorial " Cardiac Magnetic Resonance Before Ventricular Tachycardia Ablation and During Follow-Up." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260323.157498...
This week, please join author Niklas Dyrby Johansen and Associate Editor Sandeep Das as they discuss the article "High-Dose Versus Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260316.180799...
This week, please join author Michael J. Blaha as he discusses his article "Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross Cohort Collaboration." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260309.22779...
This episode features a discussion on a large study investigating the natural history of histologically proven acute eosinophilic myocarditis, revealing high mortality rates and the crucial role of endomyocardial biopsy for diagnosis, as peripheral eosinophilia is often absent. Additionally, the hosts explore new research on the genetic contributions to athletic bradycardia, endothelial protection against chemotherapy-related cardiotoxicity, and molecular insights into cardiac recovery in heart failure patients. The discussion emphasizes the clinical implications and future therapeutic directions for these conditions.
This week, join author Moritz J. Hundertmark and Associate Editor Vlad Zaha as they discuss their article "IMPROVE-DiCE, a 2-Part, Open-Label, Phase 2a Trial Evaluating the Safety and Effectiveness of Ninerafaxstat in Patients With Cardiometabolic Syndromes." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260223.163027...
This week, please join guest hosts Sana Al-Khatib and Mercedes Carnethon as first, they briefly introduce Circulation 's annual Go Red for Women® issue. Then, our hosts welcome author Emilia Benjamin and Section Editor Maryjane Farr as they discuss the unique challenges women cardiologists have faced in the past and still encounter, and the importance of mentors and mentees in the field of cardiology. Finally, our hosts welcome Ju-Young (Judy) Shin to discuss her article "Association of Statin D...
This week, join authors Shaan Khurshid and Julian S. Haimovich as they discuss their article "Incidence, Risk Factors, and Outcomes in Stressor-Associated Atrial Fibrillation: Insights From the VITAL-AF Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260209.180892...
This week, join author Chao Jiang as he discusses the article "Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20260202.172048...
This week, join authors Xiangbin Pan and Jie Dong, as well as Associate Editor Dharam Kumbhani as they discuss the article "Transcatheter Closure of Patent Foramen Ovale with a Novel Biodegradable Device: A Prospective, Multicenter, Randomized Controlled Clinical Trial." For the episode transcript, please visit: https://www.ahajournals.org/do/10.1161/podcast.20260112.347892...
This episode features a discussion on Caramatug, a humanized monoclonal antibody designed to remove amyloid protein from the heart in transthyretin amyloid cardiomyopathy patients. Dr. Matt Maurer shares promising Phase 2 trial results, highlighting significant reductions in NT Pro BNP and a favorable safety profile, paving the way for a large Phase 3 study. Additionally, the hosts review updates to PCI-related myocardial infarction definitions and other important articles in the latest Circulation issue.
This episode features discussions on three distinct studies: the role of ferroptosis in heart injury, the safety and prognostic importance of procainamide infusion for Brugada syndrome diagnosis, and how histone lactylation contributes to aortic aneurysm. The main segment analyzes the ES-BempedACS trial, which found no significant additional benefit of triple lipid-lowering therapy (statin, ezetimibe, bempedoic acid) over dual therapy in achieving LDL targets after acute coronary syndrome. Experts interpret these surprising findings, discuss trial limitations, and envision future directions for personalized lipid management.
This episode highlights the STORM-PE trial, a randomized controlled study demonstrating the superiority of mechanical thrombectomy with anticoagulation over anticoagulation alone for intermediate-high risk pulmonary embolism. It also covers research on PCSK9 inhibitors in heart transplant patients, the biological underpinnings of cardiorespiratory fitness, and an AI-based system for continuous QT interval surveillance. The discussion concludes with an overview of significant new publications from various Circulation subspecialty journals and a look into future PE research.
This week, please join our guest hosts Peter Kennel and Gurleen Kaur as they interview the recipient of the 2025 James T. Willerson Award, Michael Waight and discuss his article, "Personalized Heart Digital Twins Detect Substrate Abnormalities in Scar-Dependent Ventricular Tachycardia." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251229.893259...
This week, join author Marcely Bonatto and Associate Editor Torbjørn Omland as they discuss the article "Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251222.180775...
Drs. Reddy and Al-Khatib delve into the VCAS trial, highlighting a novel high-voltage pulsed field ablation catheter specifically designed for scar-related ventricular tachycardia. The trial demonstrated remarkable procedural success, efficient transmural lesion creation, and significant reduction in VT recurrence, marking a potential breakthrough for patients with this life-threatening condition. They also explore the future implications, including multicenter trials and applications for non-ischemic cardiomyopathy.
This week, join author Sara Moura-Ferreira and Associate Editor Ntobeko Ntusi as they discuss the article "Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251208.238882...
This week, join author Hans-Josef Feistritzer and Associate Editor Stefan James as they discuss the article "Peri-Interventional Anesthesia Strategies for Transcatheter Aortic Valve Implantation: A Multicenter, Randomized, Controlled, Noninferiority Trial." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251201.586148...
This week's Circulation on the Run covers diverse cardiac research, including insights into rare coronary artery anomalies and the molecular mechanisms of RNA splicing in heart failure. It also explores the pathogenesis of peri- and myocarditis following COVID-19 vaccination. The main feature discusses the ABC-AF risk score study, revealing that its biomarker-guided treatment strategy did not improve outcomes for atrial fibrillation patients compared to standard care, emphasizing the need for rigorous prospective testing of precision medicine tools.
This episode explores key cardiology and neurology topics, including a trial on SGLT2 inhibitors for hospitalized acute heart failure and novel research into post-heart attack scar tissue formation. The main feature details the ANGEL-REBOOT trial, examining the 1-year outcomes of bailout intracranial angioplasty or stenting following unsuccessful thrombectomy for acute large vessel occlusion stroke. Despite initial complications, long-term benefits in reducing disability and stroke recurrence are highlighted.
This week, please join authors Shingo Fukuma and Yuichiro Mori as well as Associate Editor Shinya Goto as they discuss the article "Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251110.703752...
