E5 - Timing of exercise and why it can matter with Saar Ezagouri

M.Sc. Saar Ezagouri (Gad Asher's Lab, Weizmann Institute of Science, Rehovot, Israel) talks about his study on daily variance in exercise capacity, in which he showed that mice as well as humans have a higher capacity to perform moderate intensity endurance exercise in their respective late activity phase of the day, corresponding to evening hours in humans. We discuss the role of the molecular clock, liver glycogen, and other mechanisms underlying this daily variation. We also address potential practical implications of theses findings in everyday life and whether the general population should worry about when to perform workouts for general health purposes.

Main paper that we discuss:

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity

https://doi.org/10.1016/j.cmet.2019.03.012

Other papers that we refer to in our discussion:

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial (Savikj et al. 2019)

https://link.springer.com/article/10.1007/s00125-018-4767-z

A circadian gene expression atlas in mammals: Implications for biology and medicine (Zhang et al. 2014)

https://doi.org/10.1073/pnas.1408886111

CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity (Jordan et al. 2017)

https://doi.org/10.1016/j.cmet.2017.06.002

Clock proteins and training modify exercise capacity in a daytime-dependent manner (Adamovich et al. 2021)

https://doi.org/10.1073/pnas.2101115118

PER2 controls lipid metabolism by direct regulation of PPARγ (Grimaldi et al. 2010)

https://doi.org/10.1016/j.cmet.2010.10.005

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex (Wu et al. 2019)

https://doi.org/10.1016/j.cmet.2018.11.006

AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization (Asby et al. 2015)

https://doi.org/10.1016/j.chembiol.2015.06.008

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain (Horowitz et al. 2020)

https://doi.org/10.1126/science.aaw2622

Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle (Maier et al. 2022)

https://doi.org/10.1113/JP281535

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis (Kräuchi et al. 1999)

https://doi.org/10.1016/j.cmet.2021.12.016

Saar's and Gad Asher's review on circadian control in mitochondria:

Circadian control of mitochondrial dynamics and functions (Ezagouri & Asher 2018)

https://doi.org/10.1016/j.cophys.2018.05.008

References to the marathon mice (Ronald Evans):

https://www.hhmi.org/news/researchers-identify-drugs-enhance-exercise-endurance

https://www.cell.com/fulltext/S0092-8674(08)00838-6

Saar Ezagourio on Social Media:

Twitter: @SaarEzagouri_RD

Email: saare@weizmann.ac.il