E2 - Muscle clocks with Karyn Esser

Prof. Karyn Esser from the University of Florida introduces the circadian clock present in skeletal muscle. We discuss how muscle clocks... work when comparing mice that are active at night to humans that are active during the day; influence metabolism and exercise performance; can be altered by environmental factors such as light, temperature, food intake and muscle contractions at different times of the day; are possibly involved in the development of type 2 diabetes and are affected by alcohol intake.

Main papers that we discuss:

1. Ticking for Metabolic Health: The Skeletal-Muscle Clocks https://onlinelibrary.wiley.com/doi/10.1002/oby.22826

2. Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP279779

3. Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids

https://journals.physiology.org/doi/full/10.1152/ajpendo.00187.2021

Other papers that Karyn refers to:

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock https://pubmed.ncbi.nlm.nih.gov/24567902/

How jet lag impairs Major League Baseball performance https://www.pnas.org/content/114/6/1407.long

Diurnal Differences in Human Muscle Isometric Force In Vivo Are Associated with Differential Phosphorylation of Sarcomeric M-Band Proteins https://www.mdpi.com/2227-7382/8/3/22

Karyn Esser on Social Media:

Twitter: @kaesser