Hear how human genetics is transforming neuroscience (0:55), understand how sphingolipids are key signaling molecules during development(16:34), and learn about a critical interaction in noncanonical Wnt signaling (25:34).
Learn how a sodium-calcium exchanger helps humans see in the dark (0:42), understand why one microRNA is critical for stopping autoimmune attacks in mice (7:43), and hear how light pollution is coercing some songbirds to cheat on their mates (13:21).
Hear about a strategy to reverse the muscle wasting that accompanies cancer (00:55), learn about a kinase that is a key regulator of gut regeneration (07:42), and find out about new insights into brain metabolism (14:02).
Learn how matrix metalloproteinases are involved in Huntington's disease (00:50), hear about the functions of telomere DNA sequences (9:46), and learn how the lipid diacyl glycerol helps to fight bacterial infection (16:13).
Learn about a key step in the reprogramming of fibroblasts to induced pluripotent stem cells (00:49), hear about an unexpected connection between Alzheimer's disease and autophagy (10:44) and learn how our DNA stays neatly folded (18:44).
Hear how the influenza virus mobilizes immune cells, learn about the peripatetic habits of dendritic cells, and hear about the structure of a large transcription factor called SAGA.
Hear about two new inhibitors that block the toxin ricin, keep up to date with the latest research news about type 1 diabetes (10:13), and learn how brown fat can keep you thin (16.40).
Hear how social behaviors are connected to neural circuitry (0:54), learn how optogenetics tools track the activity of neuronal populations in animals (12:38), and learn about ovarian cancer cells that are addicted to the ERBB3 oncogene.
Learn about the earliest journeys of our ancestors revealed by archaeogenetics (0:50), a versatile transcription elongation factor with several key functions in the cell (11:12) and an oncoprotein and its many partners, which are involved in leukemia (16:21).
Learn about daughter yeast cells that retain the fountain of youth (0:48), how a singing contest helps mosquitoes find the ideal mate (8:22), and a nuclear receptor that keeps fruit flies slim (13:51).
Dr. Emilie Marcus talks with two of this year's Nobel Laureates, Dr. Elizabeth Blackburn and Dr. Venki Ramakrishnan about their groundbreaking research on telomeres (1:04) and the ribosome (14:29), respectively. Learn about the connection between two major molecular players in Alzheimer's disease (29:15).
Learn about two new studies identifying a protein complex that helps with intracellular membrane trafficking (start 0:47) and hear how a key cell-cycle regulator that is overexpressed in breast cancer cells is itself regulated (9:35).
Learn about a clever way that the influenza virus outwits the host immune system (start 0:47), hear why our ancestors abandoned hunting and fishing and took up farming instead (8:55), and discover what fruit fly memories are really made of (start 13:05).
Unravel the enduring mysteries of why we sleep (start 0:52), learn about the regulation of clock genes and circadian rhythms (9:45), and hear about a study that identifies rare variants associated with breast cancer risk (start 15:42).
Learn about an X chromosome variant that protects against the progression of AIDS (start 0:50), hear about a microRNA that is decreased in both normal and cancer stem cells (start 8:08), and learn about migrating cells in the worm embryo (start 17:08).
Learn how cancer cells evade detection by macrophages (start 0:46), hear about a screen for genes that keep the genome stable (start 10:37) and new therapeutic targets for treating tuberculosis (start 16:12).
Learn how stem cells can repair damaged lung tissue (start 1:04), how delivery of a microRNA to liver tumors in mice halts tumor growth (start 10:25), and why RNA could be a useful drug target (start 18:41).
Learn how bladder epithelium regenerates after infection (0:53) and which amino acids are involved in developing insulin resistance (9:50). Hear the latest news about regulatory T cells (14:37).
Learn about a microRNA that confers robustness on the pathways regulating fly development (start 0:50), the cytokine interleukin-1 which acts as a key player in the production of Th17 cells (start 10:23) and using stem cell therapy to treat heart disease (start 15:22).
Learn about an unexpected pro-apoptotic role for the retinoblastoma tumor suppressor (start 1:22), a cytoplasmic filter in neurons (start 9:35) and an intricate molecular interaction that underpins the oxidative stress response in yeast (start 17:13).
Hear about a new study that reveals how human melanoma cells elude signals from a key growth control pathway, how to reprogram cells back to a pluripotent state, and how variations in human genes possibly contribute to human evolution.
Hear about a new study that reveals how aging cells end up with leaky nuclei and how the glossy leaves of crop plants may help to counteract global warming. And stay tuned to hear about a study in Cell Metabolism that explains how the body keeps cholesterol synthesis in check.
Hear about "TRAP," a new technique for looking at gene expression in the brain and the curious classification of the Hawaiian honeyeater. You'll also learn about a large-scale screen for mutations involved in Diamond-Blackfan anemia.
Hear about a lipid hormone made by fat that can keep you thin, and learn from the immunologist who discovered dendritic cells how these enigmatic cells can help to make better vaccines, and stay tuned to discover how the human brain controls responses to fearful memories and the implications for treating post-traumatic stress disorder.
Hear about a study that brings us a step closer to treating neurological diseases with stem cell therapy and a metabolic hormone that conserves energy during starvation. Learn more about the inner workings of a calcium ion sensor. Finally, stay tuned for our quarterly roundup of exciting research highlights published in the Cell Press family of journals.
Hear about reprogramming the body's immune B cells and also what makes brain tumors so deadly. Discover more about the insidious pathogen that causes tuberculosis ...and don't forget our quarterly round-up of exciting research highlights published in the Cell Press family of journals.
Dr Ben Barres talks about about a molecule in the immune system that is important for eliminating synapses in the nervous system and we hear about a cluster of exciting research including a gene that is important for pigmentation differences in stickleback fish and humans and a protein that controls master regulators of gene expression called microRNAs
Includes interviews with Dr Jim Collins about how several common antibiotics kill bacteria by generating lethal hydroxyl radicals and with Dr Rudi Grosschedl on how gene regulation can be coordinated by interactions between chromosomes.
Includes interviews with Dr Jonathan Weissman about new technologies that are changing the research enterprise, Dr John Kuriyan about how kinases keep themselves switched off until they are needed, and Dr Wolf-Dieter Schubert about coaxing a human pathogen to invade a mouse.
Includes interviews with Dr Francis Collins on the international mouse knockout program, Dr David Fisher on the role of p53 in tanning, and Dr Greg Hannon on pi RNAs silence transposons in the fly genome.
