Drs. Manish Shah and Sarah Rutherford explore the groundbreaking research presented at the 2025 ASCO Annual Meeting. They discuss key developments from this year’s meeting, including new immunotherapy and targeted therapy options, the use of circulating tumor cell (ctDNA) and minimal residual disease (MRD) testing, the importance of selecting the right patients for the right treatments, and more. They also provide insights into how personalized and precision treatment options have the potential ...
Aug 04, 2025
A familiar voice in a new role. Drs. John Leonard and Manish Shah reflect on the past seven years of cancer care and research as Dr. Leonard passes the microphone over to Dr. Shah as the new host of Weill Cornell Medicine’s CancerCast podcast. They reflect on how far podcasting has come since the launch of CancerCast in 2018 and discuss the biggest breakthroughs in cancer care and research, including how immunotherapies and cell therapies have transformed the field during this time. Drs. Leonard...
Jun 23, 2025
Join Dr. John Leonard for his special annual “Leonard List” episode. He shares his top 10 most interesting lymphoma and blood cancer-related abstracts to be presented at the 2024 American Society of Hematology (ASH) meeting. The ASH annual meeting features the latest and most exciting research in the field from global blood cancer experts. For the 7th year in a row, the Leonard List podcast tradition features a comprehensive look at this year’s innovative research plus 5 additional “bonus” abstr...
Nov 26, 2024
Immunotherapy is a type of cancer treatment that helps your immune system fight cancer. In the last 10 years, immunotherapy has joined the list of standard cancer treatment approaches, alongside chemotherapy, targeted therapy, radiation therapy, and surgery. There are a number of different types of immunotherapies that work in different ways to target cancer cells in the body. Immunotherapy expert and Meyer Director of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine and NewYo...
Oct 23, 2024
The American Society of Clinical Oncology, or ASCO, Annual Meeting is the largest global oncology conference and features state-of-the-art research presentations and cancer care insights from oncology professionals around the world. Every year on the CancerCast podcast, two of Weill Cornell Medicine’s leading experts discuss exciting research stemming from this annual meeting. This episode delves into the 2024 ASCO updates that patients should have on their radar across a wide range of solid tum...
Jul 31, 2024
Pathology has a crucial place in the medical field working behind the scenes to ensure patients and their care teams have the most up-to-date information. In cancer care, pathology plays an essential part in not only diagnosing cancer, but also treating and managing it. From examining tissue biopsies to evaluating blood samples, pathologists utilize a variety of tests and tools to ask and answer questions about what they observe in order to make accurate diagnoses and treatment recommendations. ...
Apr 29, 2024
The skeletal system keeps the body upright, but did you know that the bones play a number of pivotal roles in the body? From storing minerals to providing the home for new cell creation, the body’s bones are dynamic and critical to the body in various ways. When things go awry, deterioration, fractures, and pain can occur. Cancer and its treatments – especially those involving or disrupting hormonal systems – can have a big impact on bone health. Tune in for a breakdown of the bone-cancer connec...
Mar 27, 2024
Pancreatic cancer can be a difficult cancer to diagnose and treat because symptoms don’t often appear until the disease is very advanced. New imaging techniques, personalized therapies and genetic knowledge are helping to change the landscape, as well as enabling families and loved ones to access better screening tools and technologies. Ongoing pancreatic cancer research is leading to continued advancements in the management and outcomes for patients and their families. Guests : Despina Siolas, ...
Feb 05, 2024
Dr. John Leonard shares his list of the 10 most interesting lymphoma-related abstracts to be presented at the 2023 meeting of the American Society of Hematology (ASH). The ASH annual meeting brings together blood cancer experts from around the world to present the most exciting research in the field. This annual special episode features an in-depth look at this year’s cutting-edge research and also features 5 “bonus” podcast-only abstract selections. Host: John Leonard, MD, a leading hematologis...
Nov 29, 2023
The 2023 American Society of Clinical Oncology, or ASCO, Annual Meeting brought together oncologists from around the world to share cutting-edge updates and scientific advancements. Every year, two of Weill Cornell Medicine’s top experts come together to discuss the latest research presented across both solid tumors and blood cancers as it pertains to patient care. Guest: Manish Shah, MD, Chief of Solid Tumor Service and Director of Gastrointestinal Oncology at Weill Cornell Medicine and NewYork...
Jul 31, 2023
Every child inherits a set of “germline” DNA from each of their biological parents. At times there are also mutations that are passed down. This differs from what are referred to as “somatic” mutations that are only present in cancer cells, but not in every cell in the body. Environmental factors can also contribute to the development of cancers. Knowing your family history and genetic makeup can help in understanding overall cancer risk, recommended screening and prevention strategies, as well ...
Jun 23, 2023
Nutrition plays an important role in cancer care, including helping people to navigate treatment side effects. Many people like to dish out diet advice, but for cancer patients, there are unique considerations to be mindful of before, during, and after treatment. From sipping to snacking, registered oncology dietitians provide invaluable advice and recommendations to optimize health. Guests: Emily Buchholtz, RD, CDN, CSO and Stephanie Roit, MS, RD, CDN, CSO; registered oncology dietitians at Wei...
Apr 24, 2023
Colorectal cancer is the third most commonly diagnosed cancer in the United States with an increasing number of new diagnoses under the age of 55. Screening guidelines continue to evolve in an effort to find these cancers at an early stage. New surgical advancements are increasingly less invasive, reducing recovery times and hospital stays. Guest: Jeffrey Milsom, MD, colon and rectal cancer surgeon at Weill Cornell Medicine and NewYork-Presbyterian Hospital Host: John Leonard, MD, a leading hema...
Mar 29, 2023
Dr. John Leonard shares his list of the 10 most interesting and impactful lymphoma and blood cancer abstracts to be presented at the 2022 meeting of the American Society of Hematology (ASH). This episode also features 5 “bonus” podcast-only abstract selections in addition to offering extra insight into one of this year’s plenary sessions. Host: John Leonard, MD, a leading hematologist and medical oncologist at Weill Cornell Medicine and NewYork-Presbyterian Hospital....
Nov 29, 2022
Lung cancer is the leading cause of cancer death, yet it receives far less research funding than other common cancers, in part due to the stigma surrounding this disease. However, smoking is not the only risk factor – many patients are diagnosed with lung cancer who have never smoked in their entire lives. Recent advancements in screening and treatment, including targeted therapies, have helped improve outcomes and quality of life. Guest: Ashish Saxena, MD, PhD, hematologist and medical oncologi...
Nov 18, 2022
Breast cancer screening aims to catch breast abnormalities and cancers early, often before the onset of physical symptoms. There are many tools available including mammography, ultrasound, and MRI as well as image-assisted biopsies. Depending on cancer risk, breast density, and other variables, a combination of these may be used to detect breast malignancies and guide cancer treatment. Additionally, in the United States, radiologists have fought to ensure access to screenings via healthcare poli...
Oct 21, 2022
Chronic lymphocytic leukemia (CLL) accounts for about one-fourth of all new leukemia cases and diagnosis typically comes from routine bloodwork. While most cases result in a watch-and-wait strategy, understanding the underpinnings of this disease has helped advance CLL care, research and treatment. Guest: John Allan, MD, hematologist and medical oncologist specializing in the treatment and care of chronic lymphocytic leukemia patients at Weill Cornell Medicine and NewYork-Presbyterian Hospital. ...
Sep 30, 2022
Pain is one of the most common, but complex symptoms for cancer patients. Both cancer and its treatments can cause pain and managing this pain is a personalized process. While there are numerous pharmacological and non-drug based approaches, improving pain can significantly impact quality of life. Oncology care teams and pain management specialists can help patients navigate options. Guest: Abhilasha Solanki, MD, pain management physician and anesthesiologist at Weill Cornell Medicine and NewYor...
Aug 29, 2022
Kidney cancer is among the ten most common forms of cancer with about 79,000 new cases annually. It is often found incidentally but certain variables may increase risk, including factors such as family history, smoking, high blood pressure, obesity, and more. Kidney cancer can present in many ways, but common signs and symptoms, such as blood in urine, can indicate a problem with your kidneys and should be discussed with your care team. Exciting research advancements continue to improve overall ...
Jul 28, 2022
Groundbreaking updates and scientific advancements were shared at the 2022 American Society of Clinical Oncology (ASCO) annual meeting, a leading conference bringing together oncology professionals from around the world. This conversation covers top research presented across solid tumors and hematologic malignancies that is changing the landscape of care for patients with cancer. Guest: Manish Shah, MD, Chief of Solid Tumor Service and Director of Gastrointestinal Oncology at Weill Cornell Medic...
Jun 30, 2022
Marijuana, also known as cannabis, may evoke certain stigmas and associations, but when used in medicine, marijuana is a highly regulated botanical. If prescribed under proper guidance, medical marijuana can often be a helpful tool in cancer symptom management, from nausea and lack of appetite to chronic pain and beyond. Multidisciplinary cancer care teams can offer knowledge and support in navigating state-by-state legislation and prescription logistics, as well as in determining if this treatm...
Jun 10, 2022
Precision medicine leverages genetic and genomic information to help create individualized treatment plans for cancer patients. One example is an emerging test called a liquid biopsy. While traditional biopsies use more invasive tissue samples, liquid biopsies use blood tests to detect circulating tumor cells throughout the body. This technique can provide easier access to information, helping determine next steps in the cancer care journey. Liquid biopsies are a powerful tool with potential in ...
May 18, 2022
While cancer screening methods and treatments have improved over the years, there are still significant barriers that prevent access to care for many individuals. Community outreach and engagement can help to combat these health disparities and dismantle myths and stigmas surrounding cancer. Through the help of community health workers and dedicated teams, efforts are underway to bring health equity issues to the forefront in healthcare and work towards a better tomorrow with optimal health for ...
Apr 21, 2022
Procedures involving stem cell and bone marrow transplants were one of the first successful forms of immunotherapy in cancer care. Recent scientific and medical advances have led to novel approaches making transplant safer and more effective than ever before. Innovations continue to transform the field, offering alternative treatments that help the body’s immune system better recognize and fight the cancer. CAR T-cell therapy is one example which has demonstrated promising results and continues ...
Mar 28, 2022
Cervical cancer is the fourth most common form of women's cancer worldwide. While cervical cancer used to be the most common cause of cancer death for women, advances in testing and prevention – from the pap smear to the HPV vaccine – now makes it one of the most preventable forms of cancer. With all gynecologic cancers, regular check-ups are key to early diagnosis and treatment. Guest: Eloise Chapman-Davis, MD, gynecologic oncologist and Division Director of Gynecologic Oncology at Weill Cornel...
Jan 21, 2022
For the fourth consecutive year, Dr. John Leonard shares his list of the 10 most interesting and impactful lymphoma and blood cancer abstracts – with 5 “bonus” podcast-only selections – to be presented at the 2021 meeting of the American Society of Hematology (ASH). Host : John Leonard, MD, world-renowned hematologist, and medical oncologist at Weill Cornell Medicine and New York-Presbyterian Hospital....
Dec 01, 2021
Testicular cancer is an uncommon form of cancer and yet remains the #1 cancer among young men. Testicular cancer is highly treatable and curable, especially when caught early, but it’s not often talked about. Normalizing the topic and increasing awareness for regular self-checks is critical to proper detection, diagnosis, and treatment. Guest: Doug Scherr, MD, urologist and Clinical Director of Urologic Oncology at Weill Cornell Medicine and NewYork-Presbyterian Hospital. Host: John Leonard, MD,...
Nov 18, 2021
Clinical trials are pivotal in developing medical breakthroughs and advancing cancer treatments. Patient volunteers are instrumental in this research process. This behind-the-scenes look offers insight into how clinical trials are conducted and what participation entails, including safety precautions, risks and benefits, and much more. Guest: Peter Martin, MD, clinical investigator for new and promising therapies, and Chief of the Lymphoma Program at Weill Cornell Medicine and NewYork-Presbyteri...
Oct 28, 2021
Cancer and heart health can be interconnected. Cardio-oncology is an important, emerging field to help cancer patients and survivors manage pre-existing heart disease and better tolerate the cardiac side effects of certain cancer therapies. Guest: Syed Mahmood, specialized cardio-oncologist at Weill Cornell Medicine and NewYork-Presbyterian Hospital Host: John Leonard, MD, world-renowned hematologist and medical oncologist at Weill Cornell Medicine and NewYork-Presbyterian Hospital...
Sep 29, 2021
Demystifying supportive and therapeutic procedures that may be performed in the course of a cancer patient’s journey. From biopsies to port placements, tumor ablations, and other minimally invasive means of treatment, interventional radiology is a rapidly evolving field at the forefront of minimally-invasive techniques for patient care. Guest: Bradley Pua, MD, Chief of Interventional Radiology at Weill Cornell Medicine and NewYork-Presbyterian Hospital. Host: John Leonard, MD, world-renowned hem...
Aug 18, 2021
