Diffuse large B-cell lymphoma’s long-term effects on immune profiles, plasminogen activation and prevention of venous thromboembolism, and PARP inhibitors in hematological malignancies carrying epigenetic mutations

In this week's episode we'll learn about persistent changes in immune profiles in patients who have had diffuse large B-cell lymphoma, or DLBCL, and other cancers; that plasminogen activation and plasmin activity do not appear to play a role in routine physiological prevention of venous thromboembolism, or VTE; and about a novel mechanism that makes hematological malignancies carrying epigenetic mutations susceptible to PARP inhibitors.

Featured Articles:

• Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatment
• Plasminogen activation and plasmin activity are not required to prevent venous thrombosis/thromboembolism
• Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer