biosights: March 5, 2018

The nucleus comes through in the clutch

In addition to its roles in DNA replication and gene expression, the nucleus has an important physical impact on cellular behavior. Graham et al. reveal that, although the nucleus is dispensable for cell polarization and migration on 2D surfaces, it is crucial for regulating the cell's responses to mechanical cues. This biosights episode presents the paper by Graham et al. from the March 5th, 2018, issue of the Journal of Cell Biology and includes an interview with the paper's first author, David Graham, and its two senior authors, Jim Bear and Keith Burridge (University of North Carolina at Chapel Hill). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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