biosights: March 18, 2013

Breaking egg symmetry

During the first meiotic division of mammalian oocytes, the meiotic spindle and chromosomes move from the interior to the periphery of the cell. Yi et al. reveal that chromosome migration occurs in two sequential phases driven by the actin nucleators Fmn2 and the Arp2/3 complex. This biosights episode presents the paper by Yi et al. from the March 4, 2013, issue of The Journal of Cell Biology and includes an interview with senior author Rong Li (Stowers Institute for Medical Research, Kansas City, MO). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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