biosights: June 11, 2012

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form between lymphocytes and antigen-presenting cells. Babich et al. reveal that the retrograde flow of actin, largely driven by continuous polymerization, is required to sustain downstream signaling events and T cell activation. This biosights episode presents the paper by Babich et al. from the June 11, 2012 issue of The Journal of Cell Biology and includes an interview with senior author Janis Burkhardt (University of Pennsylvania, Philadelphia). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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