biosights: February 18, 2013

Erecting a myosin scaffold for cytokinesis

Cell division requires the coordinated action of proteins that promote actomyosin contraction, membrane trafficking, and extracellular matrix remodeling. Wloka et al. reveal that, in budding yeast, the type II myosin Myo1 acts as an immobile scaffold at the bud neck to organize proteins involved in forming the primary septum during cytokinesis. This biosights episode presents the paper by Wloka et al. from the February 4, 2013, issue of The Journal of Cell Biology and includes an interview with senior author Erfei Bi (University of Pennsylvania, Philadelphia). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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