biosights: April 11, 2016

Sac1 works its contacts

The plasma membrane phosphoinositide PI(4,5)P2 is derived from PI(4)P, whose levels are controlled by the essential lipid phosphatase Sac1. Sac1 is an integral ER membrane protein, but Dickson et al. reveal that it localizes to dynamic ER–plasma membrane contact sites to regulate plasma membrane PI(4)P and PI(4,5)P2 levels. This biosights episode presents the paper by Dickson et al. from the April 11th, 2016, issue of The Journal of Cell Biology and includes an interview with the paper's corresponding author, Eamonn Dickson (University of Washington School of Medicine, Seattle, WA). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

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