Episode 210: Understanding Over The Counter Drug Interactions

spk_1:   0:00
Hello, everybody.

spk_0:   0:01
Hello, everybody. And welcome to the show dog. Big show. The amazingly important show. Okay, Not really, uh, for this car most quickly, critically acclaimed podcast, it is recorded in her car. We're in the red studio today. We're headed down the road. We're going towards co Moh, Columbia, Missouri, one of the best towns in the United States. But that's not where every time I gotta I gotta admit right now I got kind of a sore knee. It is not my knee that itself to this or it's the muscles around the knee because I was over using this leg because I had some really strange where the strangest episodes of I've always had bad knees from the way back to my youth, the strangest me episode I've ever had. And there is a proper prepping point to this, By the way, there's several, but I've never seen anything quite like it. It's just one day. It was just hurting. It was swollen. It was difficult to bend. And I'm like, Oh, my goodness, have I turned something? I don't think so. It just doesn't feel structural. I've had structural problems before had multiple knee surgeries and wow, this is weird. And it got to be, too. We're getting up out of a chair was almost excruciating. It was the weirdest thing.

spk_1:   1:23
It's tricky for £120 woman help a guy that size out of a chair.

spk_0:   1:27
Yeah, I'm a bigger guy. I mean, I'm a six foot three and I'm not a small person in any way. And it was just strangest thing. And over the weekend I was just like I was taken ibuprofen, I was taking acetaminophen, and we could talk about the taking of the two at the same time a little bit in this podcast, because that's actually a thing. And I was taking what else was I take O s have some salary and cream. You have a prescription

spk_1:   1:57
for tropical topical, anti inflammatory

spk_0:   2:00
right? It is for when I have any problems that studies exactly what it's for. That's why I I have the prescription because it does pop up from time to time but never like this. And then it's the strangest thing I got up from work. I got to go to work Monday morning, and I kind of told my my my peeps, there that I was not gonna be moving around much in the office that day. I kind of have a little self under my desk, work and stick my feet up. And I kind of sat there and I worked on my desk for 23 hours and I had Thio, as we like to say in our office go south, because the the restrooms in the building are south of almost everybody, actually north of me. But that's beside the point. So I had to quote unquote go south and I got up. No swelling, no pain, no nothing. It was gone in two hours, and I have no idea how it's even possible.

spk_1:   2:54
Randomly appeared randomly disappeared with, which isn't that odd for knee problems of his type, But the speed of it wasin,

spk_0:   3:03
that is, It was I got up and I could bend my knee fully. So yeah, but what's the point of my story? Was the idea profits and the acetaminophen? It's kept me functional girls. Otherwise I probably would have been nonfunctional.

spk_1:   3:25
The ice packs helped, too. My suspicion. I am not a physician. I know some things about medicine, but I am not a licensed medical professional. So this is just me talking, all right. But one of the things the immune system does is once it gets going, it feeds itself. And it's, ah, self amplifying system. And I was tryingto interrupt that system of inflammation in his knee. So we were doing everything we could without poisoning his liver to interrupt that inflammation. So we were using two different kinds of anti inflammatory drugs that work on different pathways. So if he didn't have to Max out the dosage on any one of them, we could alternate which one's he was getting? And then if he really needed some an hour earlier than he could have taken the second dose of ibuprofen, well, it's safe to give a dose of acetaminophen if he hasn't had that for 66 hours or so. Doing that and the topical.

spk_0:   4:29
So I want to throw it a caveat. Here. Ibuprofen is over the counter drug that you really need to not overdo. We gotta

spk_1:   4:38
train. Yes, we did.

spk_0:   4:39
Um, we live. We Drake reading over trains. That's one spot of this road where we can print over train doing B A. Have you profit in particular is one that can really mess up your liver if you take way too much of it.

spk_1:   4:53
And to see the minute things on that list, too.

spk_0:   4:55
Is it? Yeah, yeah.

spk_1:   4:56
People do damage their livers. Taking too much of these over the counter drugs. They are safe is prescribed a CZ long as you have a decent liver and they do a lot of good. I'm not saying they're a bad thing or anything, but I'm saying people who take too much of them run themselves and deliver problems because they mistakenly think that if it's sold over the counter, it must be safe to abuse as well. It's safe to use,

spk_0:   5:23
right? Emin? You got other over the counter drugs that have their own else. Why? Side benefits like her side repercussions. Like some of them, uh, aspirin and some accommodation. Do the bleeding thing.

spk_1:   5:38
Aspirin does a couple of different things. One of the things it does is irritate the stomach lining in many people, and another one is it inhibits the platelet activation, which is part of how your blood clots. So people who Max dose on aspirin confined can actually give themselves ah, mild and transient form of Ah, hemophilia right where they believe much damage. It's not a good time to be in a car accident when you've been high dose ing with aspirin

spk_0:   6:07
or don't play hockey, roller derby or football while you're over those aspirin. You really don't want to do any of those things.

spk_1:   6:14
And the kids can get something called rise syndrome when they take aspirin. Where I'm not really sure how that works. I'm not sure is. Anybody's figured it out yet, but aspirin is not one you want to give the kids, and we burn all these up because they're nice over the counter medications you confined in any dollar store, and they're really useful

spk_0:   6:30
right now. We did it. Um, one moment, please. Sorry about that. We had a We had to have a conference on where we were going to go with this. I'll be straight up Originally. We have. We're agreed to record this a short little podcast to go with the dollar store, which she was signaling to the dollar store drugs article, which by the time you hear this will have been several days ago on

spk_1:   6:59
there'll be a link on the shooting.

spk_0:   7:00
Yeah, and it will be weak to the shows. Will put that lead to that in there because we did. So let's take just a minute, because we're not going to do the podcast for that. We'll just cover that article is well, in this podcast just freaking out.

spk_1:   7:12
That one was just about useful things. You confide it literally. We went to AA, one of those stores where everything in there just cost $1 so they don't

spk_0:   7:21
want family dollar. But you know, there's a whole thana. Yeah, dollar tree year. There's all kinds. Were

spk_1:   7:27
just thinking about how some people get the thought that they can't prep because they don't have enough money. And here's ah, whole store full of stuff for a dollar each.

spk_0:   7:35
We pay that.

spk_1:   7:36
We decided to wander through there and find some things that were prepping useful from the medicine section and a showcase him just to give people an idea of Okay, you can do yourself some good, even if you I have nothing but what's under the couch cushions, too. Prep list.

spk_0:   7:55
Now I wanna throw something in your the thing about medicines at the dollar store. Is these are medicines. They're labeled as medicines. Therefore, in America, at least day fall under the F D. A regulatory regulation system

spk_1:   8:17
and the FDA has zero sense of humor about miss labelling drugs or not producing them according to the specifications that are required. So even cheap actual medications are, in my opinion, quite safe and effective in the US,

spk_0:   8:38
right? You would have these journal supplements not so much. Yeah, herbals upwards are totally different story. We're wasting time. But you look at these and you look it says acetaminophen. The same ingredients is in the brand. Blam. You know, whatever this boot, whatever Brandon it happens to be. And you look at ibuprofen, the same ingredients as in the brand bone. And when it says the same ingredients active or same active ingredient is in the brand boom, they cannot lie about that without facing, like, really serious finds

spk_1:   9:16
there. Yeah, there are some differences in formulation that make a relatively minor. Generally,

spk_0:   9:23
I'm gonna tell you my personal preference in in all of these for over the counter pain relief is the gel caps because or actually the liquid is a hit you a lot faster,

spk_1:   9:33
but not for prepping because those

spk_0:   9:35
were not problems. Those are the ones I keep around for my use for prepping. You want pills? Not capsules. Not Caplets Hill.

spk_1:   9:46
Absolutely not. Gel caps Because one day in a hot backpack and you have a mess. Trust me on this one, dressed that

spk_0:   9:54
way. Actually put the picture up about some of the message we've had painted pelican gel caps. Yeah, so yeah, we learned the lesson on that. So not Joe Capsule right out for prepping.

spk_1:   10:06
Now, would I actually buy those medications for prepping at the dollar store? Generally not because you can get him in higher quantities, so they're lower cost per dose elsewhere. Right? And that's more a space efficient way to keep them for prepping. And space is an issue when you're have a lot of prepping stuff,

spk_0:   10:27
if you can afford it, a really great way to do it. It's not that expensive, but a really great what we what we d'oh with our stuff is we buy it at our warehouse club. We're Sam's people just because that's the only thing close to us, but Costco have it. Any other warehouse club that's out there will have to leave these humongous bottles. That's how we buy weed. Subdivide him up out of the bottles. Like

spk_1:   10:50
you know, we rotate. We've got a fridge where we keep the stuff. That's,

spk_0:   10:53
uh, the Pepper Chef. I did not realize I was. Now what we had to look going to look for the for the cream the other day because I needed a new tube way. Keep it course in the fridge. I had no idea. The entire bottom shelf of our refrigerator is

spk_1:   11:08
nothing. He doesn't dig in the back booth. That's where I put them with the extra extra

spk_0:   11:16
drugs. Would you say that to holy cow? I can see why you don't want a bite. The war? Yes, he's

spk_1:   11:24
wanting a weakened by its spare bottle. I'm like, Nope, really don't want to, because every time we buy a new bottle, I go to they're and I pull out the oldest one I've got. I label them is to date. When we get him, pull out the oldest one we've got. We used from that. So none of them get ridiculously old and we've always got a stock of stuff. And if something that gets really old. We just take it to the sheriff's office and dispose of it safely because they're cheap enough. And that's a cheap insurance plan. I'll do that.

spk_0:   11:54
One thing I will say about the dollar store stuff, though you could put yourself together are really nice. Little is gonna be cheap, but nobody cares on really nice little cheap, 72 hour bag type, uh, medical kit out of the dollar store. You could put almost the whole thing together and not spend 20 bucks on and get plenty of amount so that not only you have enough to use, you have enough to share, and they're gonna be in these little bitty bottles anyway. So you know, it's it's gonna be easy, Carrie. It's gonna be like, um, take a look at the article. Some of the things we put on this medical article, um, dollars from our things you might not think. What's that got to do with medicine? Dental floss? What does that got to do with medicine? Has a lot to do with preventive medicine. Toothbrushes. I don't know if we put one of those on there. They didn't rush.

spk_1:   12:50
We did not

spk_0:   12:50
know, but his toothbrush is a toothpaste. Toothpaste is medical supply. Yes, it actually is. I don't

spk_1:   12:58
want to see what happened to the cavity right in the US when we started putting fluoride started using fluoride. Oh, that's not a political comment. It's

spk_0:   13:05
political government.

spk_1:   13:06
It is not.

spk_0:   13:06
No, it isn't. You know whether

spk_1:   13:09
or not we do it to the public health supply. Okay, that's a political question. But whether or not cavity rates went down is a factual statement

spk_0:   13:17
right now, I will tell you, and some people will blow their minds. I actually use the floor. I'd wash every day, but I spit it out. So you know, I'm not actually swallowing the fluoride. So But ideas in my cavity rate, I'm he's a pro. I'm really prone. But my cavity rate has gone from riel. Serious health problem to virtually non existent since I started that. So it just is. But anyway, that's not the point of we have sun tan lotion,

spk_1:   13:50
not tan lotion.

spk_0:   13:51
No, no suntan. A sudden sunblock. Sunscreen. So the block and we have the highest number that they had we picked, which was only 50

spk_1:   14:01
fifties pretty high,

spk_0:   14:02
but yeah, go hire

spk_1:   14:04
nobody. Well, most people don't use is much as recommended. I certainly don't cause it feels nasty. I seldom use this stuff at all, Honestly, that if you have somebody who's gonna have to be out there who isn't usually especially if they're delicate skin like a kid

spk_0:   14:20
or if they're on the water or in the water. Or if the snowy out

spk_1:   14:25
snow in the where the skin's gonna be exposed Anyone

spk_0:   14:29
actually at altitude or you're going down,

spk_1:   14:31
you totally toast yourself it out, stupid,

spk_0:   14:34
or you're You know, if you are, If you're one of these fairs, get like redheads, whole poor people. I love you, redheads. I do. But I pity you. 100 suntan. A sunburn thing?

spk_1:   14:45
Yeah, and it's It's a real health issue. I'm not just talking a long term risk of skin cancer thing I'm talking about. If you get blisters and blisters break, you've got open skin and open skin invites germs.

spk_0:   14:57
Yes, So all of this stuff is dollar. Read the article. Let's get back to just briefly another. Take a look. I want you to go through the pathways, things that people really understand, how that works

spk_1:   15:12
in a few minutes. I can't do a great job, but I'll give you an idea. You

spk_0:   15:15
could put it in the article. I read the article. We've

spk_1:   15:18
got immune cells, and when they find something that they object to, like damaged tissue or invaders, they activate, and they start releasing a whole host of chemicals that starts these little chemical cascades where one triggers the next triggers. The next triggers an X, and you get a whole bunch of impressive reaction's going, like the readiness and the swelling and the heat and the fever on the loss of appetite and the body aches. All that stuff is created by the immune system when the immune system is trying to clean up stuff, and all of it has a good physiological point. It just happens to be miserable in the meantime, so the immune system can get out of hand and create more of those symptoms than are good for anybody, and certainly more than are comfortable. So we've got a variety of drugs that interrupt those pathways. Stop the production of all those immune signals that cause all those signs and symptoms. But there are multiple pathways and different over the counter drugs can work on different pathways, and different drugs are disposed of differently by the liver. So if the liver is busy getting rid of a set amount of ibuprofen and you give it some acetaminophen, well, the liver can do that at the same time, because it's using a different set of enzymes to do it. If you give it more ibuprofen, then you start to get toxicity problems. So using different things that use different pathways gives you a wider array of effects, and it reduces the risk of toxicity. That's my best short form.

spk_0:   16:52
It's pretty good shirt for mo, you know, Rubble strip. Yeah, that that's I was pretty good, you know? So, yeah, well, she's gonna She's going to do an article at some point in time. Yeah, volunteered. I love it when I'm old here. I

spk_1:   17:15
hear it on the podcast. As we're talking, I'm gonna write an article of this. How surprising.

spk_0:   17:21
But it's a good article, and it's something I've never actually seen anybody talking about in prepper circles. I just haven't and I've read a lot of prepper med stuff. I've never seen this.

spk_1:   17:32
Yeah, it's kind of ah, coming from a different angle on the path of Physiologist. I'm not a emergency med provider.

spk_0:   17:39
One moment, please. No, of course. Sorry. Go ahead. You didn't hear that? Um, I had to, uh, bring up the fact that not all, even though you have these drugs and they're labeled like, desperate, not all drugs are created equal. And not all drugs work as well as they do another. And some of these drugs have serious. And I mean serious side effects that you need to know about if you plan to use a for example, Um, the brand name is Benadryl. I don't know what

spk_1:   18:14
I think Hydra mean.

spk_0:   18:15
Diphenhydramine, dive and hydra mean knocks me out like a sledgehammer.

spk_1:   18:23
It is, in fact, what you find, they call it now they make zoom. So Zeke will to go along with e ny Quil, and they've got the same diphenhydramine in him. But one of them has the other stuff for cold and flu relief. And the other one doesn't because the diphenhydramine really really increases sleepiness and a lot of people, and they use it as a relatively safe over the counter sleep aid.

spk_0:   18:49
Right now you look, but

spk_1:   18:51
it's also a strong and a histamine,

spk_0:   18:53
but which is why it is a prime prime thing

spk_1:   18:57
for represents a very useful drug. Glad to have a lot of it around, but I'm careful about when I take it.

spk_0:   19:05
Yeah, I have to watch myself. Who are you to sleep at night? I'll take one of the things I

spk_1:   19:11
don't get all that sleepy when I do take them.

spk_0:   19:14
Oh, I data slaughters, but you don't ever I take take a pill 30 minutes later. Boo. I'm gone. That's that. That's good if I'm sitting at home and I have to fall asleep in my recliner. Yeah. Do

spk_1:   19:29
you have a sick day for a cold? Fine. Take a nap.

spk_0:   19:33
Right. But if I'm getting ready to go out, drive tow. You know a town 150 miles away. Don't take your cape, tiger. Mean? I mean, just bad things will happen.

spk_1:   19:44
We did that once by by accident, Actually, when we were young and silly and he even while I was talking to him and he was driving,

spk_0:   19:54
that was a wild ride. Apparently I slept through it.

spk_1:   19:56
Yeah, he thought of you. Thought it was fun and exciting when he woke up, but he didn't see how we missed the head on with a telephone pole by six inches,

spk_0:   20:03
was driving a limo of the time and she was in the back. I used to drive the most one of the many zillion things I have done in my life. But anyway, I was driving a limo and we were driving weary, probably five miles from town. I was almost home, and, uh, we were on an area that had ah, elevated road with a relatively mild slope and its slope down into like a farm field,

spk_1:   20:30
meaning we didn't quite roll over when we went right.

spk_0:   20:33
Um, but the problem was there were power lines running down here in. So she's talking to me, and all of a sudden I hear screaming in the car's kind of sideways almost. And I opened my eyes and, you know, I see we're kind of half fighting down the slope and we're still doing 45 miles an hour, and I mean, this is the kind of thing where you roll a car. This is a rolling, tense situation. So I counter steered, got the card going straight, and I'm like, Oh, man is gonna cost me a ton of money to get towed out here. I looked up. There s low. I could take that. I could make this. I can do this. And

spk_1:   21:18
you would have said, Hold my beer and watch this if he had a beard. Time

spk_0:   21:21
that saw. So I just I just floored it up the slope. We shot back onto the highway. Thankfully, there was nobody there out into the other lane, the oncoming traffic. Lee. Fortunately, there was nobody there. He and I'm going to tell you, Spice and I do not yell at each other. We just don't. I could probably, um, hold on the number my hand up and count the number of times that we have yellow at each other. Since we've been together for 35 years

spk_1:   21:55
out of emotion, not need another emotion project over loud.

spk_0:   21:58
Yeah, I'm not ejaculation were yelling each other because there's a lot of noise. That's what I'm talking about. Hot. Okay, that is one of the fingers I can hold because she there were There was no doubt I had offered a thriving ivory towers. The level of happiness was very very low. At this point in time, like this customer satisfaction, it would be

spk_1:   22:31
in the little one. Yeah, I would have been leaving him a bad review if I had been one of his paying customers for the

spk_0:   22:38
limo. I Oh, yeah. Excuse my language, but that was fun. Um,

spk_1:   22:49
except the part where we almost rolled and then almost hit the telephone pole. It was

spk_0:   22:52
great fun. Yeah, Yeah. I don't remember the telephone book. All right off today. I don't remember the total Bowl at all, which probably increases my level of joy over the years. So we are. We're at a stopping point. So we're gonna hang this podcast up and she's gonna stop at the farmer's market and pick up her peppers that she forgot at home so she could, like, cut one apart, eat it for breakfast, e, and we'll catch you the next time. Thanks for listening.