Thrombin Time & Fibrinogen Assays

Basics to Brilliance: Haematology Podcast

May 18, 2025•38 min•Season 2Ep. 4

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00:54 Intro and table of contents

1:48 Case 1: pre-op, prolonged PT and ++ prolonged APTT…thrombin time done

03:44 Case 2: post-op, normal PT and prolonged APTT…thrombin time done

04:46 Thrombin Time definition and ingredients (its all about the fibrinogen!)

10:45 Differentiating causes of prolonged thrombin time- protamine, reptilase, ecarin

17:24 Case 3: Major Haemorrhage (Variceal), due OGD, Derived PT Fibrinogen normal

20:45 Clauss Fibrinogen- methodology, causes of change and treatment of deranged fibrinogen

30:09 Derived PT Fibringoen

31:20 ELISA, TEG and ROTEM (brief)

33:07 Summary

36:56 David’s request (email us your questions!)

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