The Porosomal complex and complex lipid interconversions organizing the transport and secretion of cytokines after T cell Receptor Activation by APC's

There is a requirement of cholesterol  and ceramides for the maintenance of neuronal  and T cell porosome integrity, accompanying  an interaction of phosphatidic acid (PA) and polyphosphoinositide (PI) lipids with syntaxin-1A where these lipids are necessary for neurotransmitter or cytokine secretion in association with calcium channels  modulated by lipid domain formation upon sphingomelinase and fatty acyltransferase activities. 

Complex lipid  composition and three dimensional sequence topology  differs between the inner and outer leaflet of the bilayer at descrete lipid raft domains of the endomembraneous and plasmamembrane where these  macromolecular structures contribute to the polarity of transport, access, and differential signaling uniquely essential for cell communication in the CNS and immune synapse.

Published on 05 Jan 2021 Authentic Biochemistry Dr Daniel J. Guerra, Ph.D.

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