Multiple Transcription Factor functional integration from immune cell lineages coordinate gene expression that maintains responses to intestinal infection during aging

Since epithelial clock gene and  lymphocyte transcription factor Nfil3 expression is elevated in recombination deficient mice  the potential for  increased bacterial populations lining the gut may induce  an expansion of class 3 innate-like T lymphocytes (ILC3) in the small intestine. thus allowing for circadian clock activity maintenance and effective immune clearance of potential pathogens. This observation may provide a potential pathobiochemical link between obesity and the increasing pathophysiology associated with human aging.

Dr. Daniel J. Guerra Authentic Biochemistry Publication 10 November 2020 

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