Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
May 14, 2021•30 min
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Episode description
TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling.
TLR interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's.
J Neuroinflammation. 2014 Sep 20;11:166
Brain Behav Immun. 2019 Oct;81:41-51
J Mol Neurosci. 2021 Mar 9
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