Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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Episodes

Authentic Biochemistry Podcast Alzheimer's Disease Pathobiochemical Inception Involves Mitochondrial Dysfunction. Dr. Daniel J. Guerra.27.8.24.

References Brain Research 2024.April 15. Vol. 1829.article 148793 John Kay , Jerry Edmonton , Nick St. Nicholas , Larry Byrom , 1969. Steppenwolf. Monster title cut. https://open.spotify.com/track/0UwWLG6L2vm1r1fd1QDHqy?si=6a73e4a6eacd4328...

Aug 27, 2024•48 min

Authentic Biochemistry Podcast. Primer; Nucleotide Biochemistry I DJGPhD.25.8.24

References Guerra, DJ. 2024 Nucleotide Graduate lectures Hunter-Garcia 1970. "Attics of my Life" Grateful Dead [American Beauty, lp.] https://open.spotify.com/track/6WeLHc9eLjVJqOKhd97vaK?si=d93bcc38ba7d4bac

Aug 26, 2024•29 min

Authentic Biochemistry PodcastIntermediary metabolism, epigenetics, and the endomembranous network surveil, ascertain, and deliver upon cellular event ontology Including AD pathology.DJGPhD.24.8.24

References Free Radic Biol Med. 2021 Jul; 170: 59–69. Biomolecules.2021 Feb; 11(2): 195.

Aug 25, 2024•1 hr

Sphingolipids in AD: The Fragmentation of Mitochondrial DNA and Innate-Immune activation of inflammasomal CNS pathologies Dr Daniel J. Guerra 23.8.24 Authentic Biochemistry Podcast

Refs Front mmunol.2019; 10: 1064 Fosdick and Poulton 1956. Love me Tender https://youtu.be/v5SkY9WHekg?si=q5Xhq32IHBNYdj81

Aug 23, 2024•38 min

AD is a Neurodegenerative Disease associated with Cytoepigenetic Interactions between the Nuclear and Mitochondrial Genomes. Authentic Biochemistry Podcast.c.8.Dr. Daniel J. Guerra.19.8.24

References Front. Immunol., 2024Sec. Multiple Sclerosis and NeuroimmunologyVolume 15 22 February Mozart. WA 1778. Sinfonia Concertante. https://youtu.be/_0hTDZ0whpU?si=s4JhUsyFr1WZk4AQ

Aug 19, 2024•57 min

Immune and neuropathophysiology of CYTOEPIGENETICS Dr. Daniel J. Guerra 18AUGUST 202

References Guerra, Daniel J. 2022. December Journal of Disease and Global Health .DOI: 10.56557/jodagh/2022/v15i38023 Lamm, R. 1969. "Beginning's" CTA. https://youtu.be/lI-BMDnti4c?si=ZCt7yL3xRRrH2l_b...

Aug 19, 2024•39 min

Authentic Biochemistry Podcast Sphingolipid, ROS Mitochondrial Involvement associated with Nuclear Histone Acetylation in Alzheimer’s Disease 14.8.24 Daniel J. Guerra, PhD

References Guerra, DJ 2024 Lecture materials

Aug 15, 2024•51 min

Inter Alia, The PDH/LDH/PDHK Axis for T Lymphocyte Activation intersection with AD pathobiochemistry. DJGPhD. 12AUG24

References Neuromolecular Medicine. 2018. Jun. 20(2): 1559-1174 Cell Rep. 2018 Feb 6; 22(6): 1509–1521 Cell Cycle .2008.7(15):2296-8 Front. Immunol., 18 June 2013 Sec. T Cell Biology Tchaikovsky, PI. 1874. Piano Concerto 1. B Minor. Opus 23. https://youtu.be/W6Zr_0LYYTI?si=YlrIK-UDVGHbMp4P...

Aug 13, 2024•1 hr 5 min

AD and Sphingolipids c.5 Sphingomyelinase and Ceramide molecular heterogeneity in AD is associated with bioenergetics and Ketone availability. Authentic Biochemistry. 11Aug24 Dr. Daniel J. Guerra

References EBio Medicine. 2015 Dec; 2(12): 1888–1904. J Atheroscler. Thromb.2023. Dec 1; 30(12): 1751–1758. Russian Orthodox Voices: https://youtu.be/z_M6YbsmT-I?si=l-U5ZwH90oCBbwAR

Aug 12, 2024•58 min

Authentic Biochemistry Podcast. Sphingolipids and Alzheimer’s Disease c.4 [09AUGUST24] Dr Daniel J. Guerra

References Front. Cell Dev. Biol.2019. 15 August Nat Rev Methods Primers. 2021. 1:30. Chemical Reviews. 2021.Vol 121/Issue 12 RSC Adv. , 2024, 14 , 7383-7413 Lennon/McCartney. 1970 "Let it Be https://youtu.be/QDYfEBY9NM4?si=b6-yGPS63sh8fEtC Lamm, R.1972. "While the City Sleeps" [Chicago V.lp] https://youtu.be/qCrgrGsBlr0?si=OSzuavyf40aEDn-r Mozart WA . 1791.Requiem in D minor K.626 https://youtu.be/YaH3zI0bYkM?si=o6vConcxFJYVXrqP...

Aug 10, 2024•55 min

Sphingolipids and AD. c.3. 07Sept 24.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra

References Pharmaceutical Research. 2018, March. 35:49 J. Lipid Research. 2018 Apr;59(4):596-606. J Biol Chem. 2016 Jan 22;291(4):1957-73 Front. Cell Dev. Biol. 2019. 15 August Nat Rev Methods Primers. 2021. 1:30 Hunter, R. 1974. "It Must Have Been the Roses" Grateful Dead. https://youtu.be/OhFGxZZpdls?si=fWanXYQv3iJzaZKw Dawson, J. 1971."Last Lonely Eagle" NRPS. https://youtu.be/WGxSYOZVhlM?si=bHzJXV0OiKXWBAic Bruch, M. 1866. Violin Concerto 1 in G Minor.Op.26 https://youtu.be/KDJ6Wbzgy3E?si=BG...

Aug 08, 2024•1 hr 13 min

Authentic Biochemistry Podcast . Alzheimer's Disease involves intercellular trafficking of A-beta to the microglia via ceramide stereoisomer specified exosomal transport. c.2. DJGPhD.05Sept24

References FASEB J .2008. 22:2541-2551 Nat Commun. 2023 Jul 7;14(1):4029. Seminars in Cell & Developmental Biology.2015. Volume 40, April : 115-126 CHIRALITY. 2023. Volume35, Issue9 September:577-585 Lake, G . 1972. "From theBeginning". Trilogy.lp ELP. Begihttps://open.spotify.com/track/1rw12PalmC8IDoygHT3fm1?si=535ae4023d064b16 Telemann, GP. 1720-1740. Various Concertos. https://open.spotify.com/album/1KYduuF73q2mCqoeEWmpw9?si=pNd2NVG1Sbu_B_z8vbQalA...

Aug 05, 2024•1 hr 19 min

Authentic Biochemistry Podcast. “Scientism non fengo” Dr Daniel J. Guerra 02August24

References Guerra, DJ. 2024. unpublished Sarasate, P.de, 1881. The Carmen Fantasy, Op. 25. https://youtu.be/sYh0fnhKJEo?si=uRDSfFyNgI2o_fNs Anderson,Squire, Bruford,Wakeman. 1971."Heart of the Sunrise" Yes, [Fragile,lp.] https://youtu.be/0vNcgL9Fi4w?si=szH6TVaeyHy_vc2D

Aug 03, 2024•1 hr 1 min

Authentic BiochemistryPodcast. Sphingolipid Involvement in AD. c.1. 01August 2024. Dr Daniel J. Guerra

References Chirality. 2023. Volume35, Issue9 September Pages 577-585. J. Lipid Res. 2018 59:(3) 488-506. JME 2017. -16-0182 V.58.Issue1. r59-71 Pharmaceutical Research 2018, March.35:49 Barber, S. 1967. Agnus Dei https://youtu.be/0LYnNEALm6o?si=M0Y7qsDRgDznmEOI Scarlotti, D. 1720-1740. Various Sonatas. https://youtu.be/X-JaVGYG2i8?si=9s6RXDgTkNFsJEwp

Aug 02, 2024•1 hr 4 min

Photosynthesis. IV. Authentic Biochemistry Podcast. Dr Daniel J. Guerra.31.7.24

References Guerra, DJ 2024. Lecture material Anderson and Howe 1972. "Close to the Edge" Yes. https://youtu.be/51oPKLSuyQY?si=p1MBzMqcJ8QHpAb-

Aug 01, 2024•48 min

Photosynthesis III. Midsummer. Authentic Biochemistry Podcast.DJGPhD.29.7.24

References Guerra, DJ. .2024. Lectures series notes Phys. Chem. Chem. Phys. 2020.22.7912-7934 Biber,HF. 1674. Rosenkranz Sonaten. The Mystery SonatasI https://youtu.be/Mq-SrUZUluU?si=um9GDZWWmw52uRUX Baker&Taylor. 1968 "Those Were The Days" On Wheels of Fire; lp CREAM. https://youtu.be/zofyj090Exw?si=Qy62A2xKC3YUytEb

Jul 30, 2024•1 hr 28 min

Authentic Biochemistry Midsummer Lecture Series. Plant Biochemistry Interlude II. Chloroplast Lipids and Photosynthesis. 27.7.24.

References Plant Physiology 2011. 157(4):1746-64 Methods Mol Biol. 2016; 1376: 175–194 J Biol Chem. 2018 Sep 21; 293(38):14786–14797 Mozart, WA. 1786. Voi che sapete" (from: Le nozze di Figaro, K492.) https://youtu.be/tH93uhBs5m8?si=GVfvA5r_QlrVJJgq

Jul 28, 2024•50 min

Authentic Biochemistry Midsummer Lecture Series. Plant Biochemistry Interlude. Photochemistry I. Dr Daniel J. Guerra 26.7.24

References Guerra, DJ.2024. Lecture notes Plant Cell. 2013 Jul; 25(7): 2661–2678 Peer J. 2023; 11: e15696 Gilliland and Massey. 1955. Sid King and the 5 Strings. "Sag, Drag and Fall." https://youtu.be/9KJzeOmHgc4?si=4GjA5H4stZDDl9nT

Jul 26, 2024•1 hr 20 min

Immune Cell Biochemistry. B cells C.23 Postscript Authentic Biochemistry Podcast. Dr Daniel J. Guerra 23.7.24

References Ungurianu, A., Manuela Drăgoi, C.,CrenguțaNicolae, A., Dumitrescu,I.-B., Grădinaru, D.,& Margină, D. (2024). Sirtuins and Melatonin: Linking Chronobiology to Inflammation andAging. IntechOpen. doi: 10.5772/intechopen.1003914 Christina M. Ridley et al. J. Biol.Chem. 2013;288:26052-26066 Journal of Cell Science 2005 118:4605-4612 PLoS One. 2015; 10(9): e0137193. Goffin and King. 1968. "Wasnt Born to Follow" Byrds. https://youtu.be/PrU9iI2VxPE?si=H3txVRenVEJ6KkNs...

Jul 23, 2024•1 hr 17 min

Saturday evening biochemical metaphysics. Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 20.7.24

References Guerra, DJ. 2024. Unpublished material. La Flame and baker. 1970. Its a Beautiful Day. "Hot Summer Day" https://youtu.be/PUXOSe_m_dc?si=752n4PanhqKP8nFv

Jul 21, 2024•41 min

Immune Cell Biochemistry II. B lymphocytes. c.22. Final Synthesis Authentic Biochemistry Podcast Dr. Daniel J. Guerra 18.7.24

References J Pineal Res. 2017;62:e12391 PLoS One. 2015; 10(9): e0137193 Aging. IntechOpen. (2024). Sirtuins and Melatonin: Linking Chronobiology to Inflammation and Aging. doi: 10.5772/intechopen.1003914 Blood Cancer J. 2024 Dec; 14(1): 24 The Byrds (multiple artists). 1968. ""Sweetheart of the Rodeo". (Lp). https://youtu.be/zxzV5XoLpto?si=OFb3eHDb2ghdz16V Ravel, M. 1928. "Bolero" . M 81. https://youtu.be/E9PiL5icwic?si=a9rYVLbBexOhR0M4...

Jul 19, 2024•56 min

Immune Cell Biochemistry II. B lymphocytes. c.21. CD38 NAD+ hydrolase mediates the Inflammatory Response Authentic Biochemistry Podcast Dr. Daniel J. Guerra 16.7.24

References Cells 2020, 9(1), 228 Front. Immunol. 2020. vol 11. 29 November. FEBS 2013. Volume280, Issue15 August:3530-3541 Cell Metabolism 2016. 23, 1127–1139 Beethoven. LV . 1800. Septett Es-Dur op. 20 https://youtu.be/pXsj43qCcUA?si=r5vW4PpfzvywF9b3 Jacques Revaux Gilles Thibaut and Claude François 1967. "My Way". Sinatra https://youtu.be/qQzdAsjWGPg?si=YWKurvGp9Xt0TYK1...

Jul 17, 2024•1 hr 1 min

The Prevailing Gignesthai of Biological Systems: “In inceptum finis est”.Dr. Daniel J. Guerra. Authentic Biochemistry Podcast. Lectures on Biochemical Epistemology.14.7.24

References Guerra, DJ. 2024. Unpublished works Schubert, F. 1827. Piano Trio No. 2, op. 100 (D929) https://youtu.be/yFyv7c1XyYU?si=T0VYKT-EJ5wQmQZU Moody Blues. 1968. In Search of the Lost Chord lp. https://youtu.be/gEj3NOW_ctw?si=Uwc1evf38wMAXdJ_...

Jul 15, 2024•1 hr 8 min

Immune Cell Biochemistry II. B lymphocytes. c.20. The gignesthaic a priori events controlling pro and anti-oxidative metabolism are linked to the core circadian oscillator complex via multiple events.

References Circ Res. 2018 Sep 14; 123(7):868–885. IntechOpen. 2024. doi: 10.5772/intechopen.1003914 Intl Myeloma Foundation 2024. Clin Biochem Rev. 2009 Aug; 30(3): 105–111. Br J Pharmacol. 2018. Aug; 175(16): 3251–3262 Int J Mol Sci. 2020. Nov; 21(22): 8609 Telemann, G.P. 1733. Tafelmusik https://youtu.be/VTP9evStK64?si=3m_Mw3B7IFo0i_el

Jul 14, 2024•54 min

Immune Cell Biochemistry II, c.19. Fine e. CNS and Immune B cell Sirtuin and melatonin regulation of inflammation and gene expression in senescence and disease. DJGPhD.11.July.24.

References Circ Res. 2018 Sep 14; 123(7): 868–885 Ungurianu, A., Manuela Drăgoi, C.,Crenguța,Nicolae, A., Dumitrescu,I.-B., Grădinaru, D.,& Margină, D.2024. IntechOpen. doi: 10.5772/intechopen.1003914 Blood Cancer J. 2024 Dec; 14(1): 24

Jul 11, 2024•57 min

Immune Cell Biochemistry.Authentic Biochemistry Podcast Glucosyl Ceramide and NAD+. B cells lecture c.18 Fine d July 9, 2024 Dr Daniel J. Guerra

References Nature Reviews Endocrinology 2020.volume 16:224–233 Blood Cancer J. 2024 Dec; 14(1): 24 Blood (2009) 114 (22): 1349. BioMedicine Hub 2021. 6:138-144. Int J Mol Sci. 2019 Mar; 20(5):1223. Lamm, R. 1969. "Does anybody really know what time it is? "[CTA lp] https://youtu.be/9FzCWLOHUes?si=kh_0eQNVliY_YieT Miller, S. 1970. "Industrial military complex blues. [Steve Miller Band V. lp] https://youtu.be/VNQsNq4zBIM?si=xeB3npYCqIw287_q Byrd. J. 1969. "American Metaphysical Circus" https://you...

Jul 09, 2024•57 min

Immune Cell Biochemistry. Authentic Biochemistry Podcast Multiple Myeloma Sphingosine 1-P Associations. B cells lecture c.17 Fine (c) July7, 2024 Dr Daniel J. Guerra

References Guerra, DJ. 2024. Lipid lectures. Blood Cancer J. 2024 Dec; 14(1): 24 Haydn.JM.1771. Requiem Mass in C Moll. https://youtu.be/0ywDPn2Ykks?si=hkL4RzjRl7WbiVER Mann, M . 1978. "Institute Chicago" Manfred Mann Earth Band. [Watch, lp] https://youtu.be/99306Peyit0?si=dQgB8m7_TmkRpXsW

Jul 07, 2024•1 hr 3 min

Dialectical Synthesis IV. The GABA/Glutamate axis and the complexity of symmetry composed a priori. DJGPhD.03July24. Authentic Biochemistry Podcast

References Guerra, DJ. 2024. Manuscripts in preparation. Paganini , N. 1819. Violin Concerto No 1. Op6. https://youtu.be/e52mkjorLAY?si=YhamClbb9LkUWOGf Hunter-Garcia. 1972. "US Blues" Grateful Dead https://youtu.be/cr-iGxbALnc?si=ImRdGq0Evh03vUd2 Miller, S. 1968. "Livin' in the USA" https://youtu.be/6Hv6WXSt7vs?si=JLdzYmlWuyRp8uIm Simon, P. 1968. "America" https://youtu.be/Eo2ZsAOlvEM?si=ahFS-qll3oKvw-bl

Jul 04, 2024•51 min

Immune Cell BiochemistryAuthentic Biochemistry Podcast Multiple Myeloma Dyslipidaemia B cells lecture c.16 FineB July2, 2024 Dr Daniel J. Guerra

References Nature Metabolism.2019.volume 1, pages754–764 Blood Cancer J. 2024 Dec; 14(1): 24. Front Oncol. 2022; 12: 925807 Miller, S. 1970 "Going to the Country" SMB-V https://youtu.be/c6yZI0fWtSI?si=03JpEJx0LzZqKD4D

Jul 02, 2024•42 min

Immune Cell Biochemistry.Authentic Biochemistry Podcast Multiple Myeloma Dyslipidaemia. B cells lecture c.15 Fine(a) 30.6.24 Dr Daniel J. Guerra. Authentic Biochemistry.

References Clin Exp Med. 2023; 23(7): 3373–3390. Blood Cancer J. 2024 Dec; 14(1): 24. Archivum Immunologiae et Therapiae Experimentalis. 2013 .Apr;61(2):119-25. Int. J. Mol. Sci. 2019, 20(6), 1505. Winkelmann, B. 1970."Good Morning" Steve Miller Band V. https://youtu.be/RhI-46SbsDk?si=ovfiAZREgBKUBOBw Lennon-McCartney. 1967. "Good Morning" Beatles. Sgt. Pepper's Lonely Hearts Club Band. https://youtu.be/sjb9AxDkwAQ?si=lK_S8CJ8sfeYil3g Saint-Saëns, C. 1886.Symphony No 3 in C minor, Op 78 https://...

Jul 01, 2024•52 min

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