Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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Episodes

Diabetes XXIII. Obesity-associated IL6 and sphingosine 1-phosphate are linked to breast cancer.Dr. Daniel J. Guerra. 31 March 2022. Authentic Biochemstry

References Dr. Guerra's lecture notes Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042 Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.

Apr 01, 2022•30 min

Diabetes XXII. Obesity and cancer are linked by inflammation and dyslipidaemia. Dr Daniel J. Guerra. 30.3.22 Authentic Biochemistry

References Dr Guerra's lectures notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725 Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.

Mar 31, 2022•30 min

Diabetes XXI. TAG accumulation in skeletal muscle of diabetics vs athletes and suggested role of Intramuscular TAG in Insulin Resistance due to subcelluar localization of lipid droplets. DJGPhD.27.3

References Dr Guerra's lecture notes Diabetologia. 2021 Jan; 64(1): 168–180 Diabetologia. 2020 Dec;63(12):2654-2664

Mar 28, 2022•30 min

Diabetes XX. Intermediary metabolic allosteric regulation in the Myocardial Infarcted heart reveals HF aetiology from obesity-linked Type 2 Diabetes. DJGPhD.25.3.22. Authentic Biochemistry Production

References Dr. Guerra lecture notes J AM Coll Cardiology Basic Trans Science.2019. (4) 3: 385-400

Mar 25, 2022•30 min

Diabetes XIX. THe ketogenesis bioenergetic system can be corrupted via DAG-kinase mediated pyroptosis in the obese/T2D CNS. Dr. Dan Guerra. 22.3.22. Authentic Biochemistry Podcast

References Dr. Guerra lecture notes Circulation Research Volume 128, Issue 10, 14 May 2021; Pages 1419-1420 Adv Exp Med Biol . 2017;960:135-160. Current Opinion in Clinical Nutrition and Metabolic Care Issue: Volume 21(4), July 2018, p 260-266

Mar 22, 2022•30 min

Diabetes XVIII. Myokine mediated muscle mass signaling is corrupted by obesity linked Type 2 diabetes via massive inflammation and dyslipidaemia.DJGPhD. 21.3.22. Authentic Biochemistry

References Dr. Guerra's lecture notes J Immunol. 2018 Nov 15;201(10):2934-2946 Endocr Rev. 2020 Aug; 41(4): 594–609.

Mar 21, 2022•30 min

Diabetes XVII. Short and medium chain fatty acid derived ketones and skeletal muscle Myokines to improve cognitive and homeostatic well-being in humans. DJGPhD. 20.3.22 Authentic Biochemistry.

References Dr Guerra lecture notes Endocr Rev. 2020 Aug; 41(4): 594–609 Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) 2021 Volume7, Issue1 e12217

Mar 21, 2022•30 min

Diabetes XVI. Fornix white matter fascicular region of the hippocampus nuclei is spared from neurodegeneration by dietary medium chain saturated fatty acid. DJGPhD.Authentic Biochemistry19.3.22

References Dr Guerra's Lecture notes Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) Volume7, Issue1 2021 e12217

Mar 19, 2022•29 min

Diabetes XIV. The Neuropsychiatric/Neurodegeneration axis from Sphingomyelin Degeneration to Increased Inflammation. Dr. Daniel J. Guerra. 17.3.22. Authentic Biochemistry Productions

References Dr Guerra Lecture archives Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) 2021.Volume7, Issue1 e12217 EBioMedicine. 2015 Dec; 2(12): 1888–1904

Mar 17, 2022•30 min

Diabetes XII. Free fatty acid dyslipidaemia associated dysregulation of hepatic and skeletal muscle Insulin Receptor Substrate (IRS)1/2 axis. Dr. Daniel J. Guerra15.3.22. Authentic Biochemistry .

References Dr. Guerra's lecture notes Curr Med Chem. 2017;24(17):1827-1852 Journal of Hepatology 2012 56, 704-713DOI: (10.1016/j.jhep.2011.09.020)

Mar 16, 2022•30 min

Diabetes XI. Biometrics in research interpretation. Dr Dan Guerra 14.3.22 Authentic Biochemistry.

Reference George A, Stead T S, Ganti L (August 26, 2020) What’s the Risk: Differentiating Risk Ratios, Odds Ratios, and Hazard Ratios?. Cureus12(8): e10047. doi:10.7759/cureus.10047.

Mar 14, 2022•30 min

Diabetes IX. The role of peroxisomes in ether-linked lipid biosynthesis. Dr.Daniel J. Guerra. 07March2022. Authentic Biochemistry Podcast production

References Dr Guerra's lecture material

Mar 08, 2022•30 min

DiabetesVIII. Subcellular organization and the role of lipid metabolism in mitochondria and peroxisomes. Dr Daniel J. Guerra. 05March22. Authentic Biochemistry

From Dr. Guerra's lecture archives

Mar 05, 2022•30 min

Diabetes VII. Cholangiocarcinomas and the corruption of the biliary system as sequalae of obesity and associated pancreatic exocrine insufficiency of diabetes. Dr Dan Guerra. 3.March.2022. A.B.

References Dr Guerra's lecture notes World J Gastroenterol. 2013 Nov 14; 19(42): 7258–7266. Int J Endocrinol. 2015; 2015: 595649. PLoS One. 2017; 12(10): e0186643. BMC Cancer. 2019; 19: 185

Mar 04, 2022•30 min

Diabetes V . PEI and Diabetic Dyslipidaemia with Primary Cholagiocarcinoma. Primer on lipid digestion and Lipoprotein Trafficking. Dr. Dan Guerra. Authentic Biochemistry 01.March.2022

References Dr. Guerra lecture notes BMC Cancer. 2019; 19: 185.

Mar 02, 2022•30 min

Diabetes IV. Pancreatic Exocrine Insufficiency in Types I, II, and III Diabetes Mellitus. Dr DAniel J. Guerra. 28.2.22. Authentic Biochemistry

References Dr. Guerra Lecture notes Int J Endocrinol. 2015; 595649

Mar 01, 2022•30 min

Diabetes III. Sphingosine 1-Phosphate in glioblastoma and prostagladin E2/EP4 in diabetic nephropathy-an axis of angiogenesis. Dr. Daniel J. Guerra. 25.2.22 Authentic Biochemistry

References Journal of Biological Chemistry.2013. 288 Issue 52 Pages 37355-37364. Prostaglandins & Other Lipid Mediators. 2022(April) . Volume 159, 106621

Feb 26, 2022•30 min

Diabetes II. The Insulin resistance factor and glucose intoxication associated dyslipidaemia and introduction to diabetic nephropathy. DJGPhD. 23.2.22. Authentic Biochemistry Podcast.

References Dr. Guerra's lecture notes Prostaglandins & Other Lipid Mediators 2022.April. 159. 106621 Reviews in Endocrine and Metabolic Disorders. 2020. 21: 631–643

Feb 24, 2022•30 min

Type 2 Diabetes I. Initial lecture describing insulin resistance and dyslipidaemia. Dr Daniel J. Guerra 22.2.22 Authentic Biochemistry Podcast.

References Dr. Guerra lecture notes Reviews in Endocrine and Metabolic Disorders. 2020. 21: 631–643. J Lipid Res. 2015 Mar; 56(3): 588–598.

Feb 23, 2022•30 min

Fatty Acids IX. The Monounsaturated fatty acid inhibition of ferroptosis and apoptosis leads to cancer progression. Pharmacotherapeutic Considerations. Dr Daniel J. Guerra. 17.2.22 Authentic Biochem.

References Dr. Guerra's notes-unpublished Cancer Res. 2019 Oct 15; 79(20): 5355–5366.

Feb 18, 2022•30 min

Fatty Acids VIII. The Potential for Ferroptosis enhancement via inhibition of Stearoyl CoA Desaturase as pharmacotherapy in Pancreatic Ductal Carcinoma.DJGPhD.16.2.22. Authentic Biochemistry.

References Redox Biol. 2021 Jan; 38: 101807 Cancer Res. 2019 Oct 15; 79(20): 5355–5366.

Feb 16, 2022•30 min

Fatty Acids VII. Stearoyl CoA Desaturase biochemistry and assocation with immune and metabolic disease. Dr Dan Guerra

References Dr Guerra Lecture notes Chem Biol Interact. 2019 Dec 12; 316: 108917 Chapter 7. Cook and McMaster. 2002. in Biochemistry of lipids, lipoproteins and membranes 4th edition. Elsevier Science. Vance and Vance eds.

Feb 12, 2022•29 min

Fatty Acids VI. The Inflammasome paradigm and transcription factor-mediated cytokine production as result of high carbohydrate diet and obesity. Dr. Daniel J. Guerra. 10.Feb 2022. Authentic Bichem.

References Chem Biol Interact. 2019 Dec 12; 316: 108917 J Neuroinflammation. 2019; 16: 236.

Feb 11, 2022•27 min

Fatty Acids V. Ketogenesis as a therapeutic to redistribute preserved Heart Failure cardiac ejection fraction via blockage of mitochondrial protein hyperactylation. DJGPhD.9FEB22. Authentic Biochem.

References Circulation Research 2020.Volume: 128, Issue: 2, Pages: 232-245, DOI: (10.1161/CIRCRESAHA.120.317933) J Neuroinflammation. 2019; 16: 236.

Feb 10, 2022•30 min

Fatty Acids IV. Adipocyte lipases and the Diacylglycerol PKC/PKD circuit of cellular degeneration leading to chronic inflammation-associated obesity. DJGPhD.07.Feb.22. Authentic Biochemistry

References Adv Exp Med Biol . 2017;960:135-160. Lipids in Health and Disease volume 19 , Article number: 113 (2020) Circulation Research. 2020.Volume: 128, Issue: 2, Pages: 232-245

Feb 08, 2022•30 min

Fatty Acids III. The inflammatory diseases and the correlation to dyslipidaemia. Dr Dan Guerra. 05 February 2022. Authentic Biochemistry Studios.

References Dr. Guerra's lecture notes Infect Immun . 2013 Dec; 81(12): 4478–4489 Am J Gastroenterol. 2004 Nov;99(11):2147-9 Front Immunol. 2019 Jun 7;10:1309 Nat Rev Gastroenterol Hepatol. 2019 Dec 9.

Feb 06, 2022•30 min