Anabolism V. The nucleic acids. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast.28.01.22
References Dr. Guerra's lecture notes
Jan 29, 2022•30 min
Authentic Biochemistry
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Episodes
Anabolism IV. Cholesterologenesis. Dr Daniel J. Guerra. 26 January 2022. Authentic Biochemistry Podcast
From Dr. Guerra's lecture notes
Jan 27, 2022•30 min
Anabolism III. Fatty acid synthesis de novo . Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Productions. 25.01.22
References Dr. Guerra lecture notes
Jan 26, 2022•30 min
Anabolism II. The role of Acetyl CoA Carboxylase isoform expression and discrete allosteric regulation in controlling hepatic fatty acid metabolism. Dr Dan Guerra. 23.01.22. Authentic Biochemistry.
Malonyl CoA controls the categorical/biochemical logic of hepatic glucose and lipid homeostasis via metabolic inhibition of metabolic antimony. References Dr Dan Guerra Biochemistry Lecture Notes. 2010-2021 Vance and Vance Biochemistry of Lipids, Lipoproteins and Membranes 4th ed. 2002. Elsevier Publisher.
Jan 24, 2022•30 min
Anabolism I. Dr Daniel J. Guerra Authentic Biochemistry Podcast Production 22.01.22
Basic reductive biosynthesis as an exemplar for this first lecture in anabolism.
Jan 23, 2022•30 min
Membrane lipid provide the architectonic signatures for cellular interactions including avirulence and either systemic and systematic-inflammatory disease. DJGPhD. 17.1.22. AuthenticBiochemistry
References J Biol Chem. 2016 Feb. 291(7): 3658–3667 J Biol Chem 2013 Dec. 288 (52): 37355-37364 Biophys J. 2005 Feb;88(2):1091-103 Infect Immun. 2018 Jul; 86(7): e00035-18
Jan 17, 2022•1 hr
Porphyria gingivalis derived dihydroceramides and serine dipeptide lipids secretion induce periodontitis and systemic hyperinflammation as associated with obesity and high sucrose diet. DJGPhD.16.1.22
References Infect Immun. 2018 Jul; 86(7): e00035-18 J Biol Chem. 2019 Jun 7;294(23):9213-9224 Egyptian Journal of Basic and Applied Sciences. 2018. (5) 4 : 237-244 Arteriosclerosis, Thrombosis, and Vascular Biology. 2019. (39) 3: 432-445
Jan 17, 2022•29 min
Dihydroceramides as virulence factors in periodontal disease. Dr. Daniel J. Guerra Authentic Biochemistry. 15 January 2022
References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Infect Immun. 2018 Jul; 86(7): e00035-18
Jan 16, 2022•29 min
Pathogenesis and Virulence are Linked to Alterations in the Infection Court via Secretion of Bacteriocins in Dental Plaque-producing Caries and S. pneumoniae Migration to the Lower Respiratory Tract.
References J Dent Res. 2019 Nov;98(12):1315-1323 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1996.Vol. 335, No. 1, November 1, pp. 102–108,. Nature Reviews Microbiology. 2003. volume 1, pages219–230 Front. Microbiol. 2021. 14 July
Jan 14, 2022•30 min
Acquired Molecular Evolution of Antibacterial Resistance Unintentionally Selected via Pharmacotherapy to Counteract Natural Avirulence. DJGPhD. Authentic Biochemistry. 12.Jan2022
References Infect Immun . 2013 Dec; 81(12): 4478–4489 Journal of Molecular Evolution 2020. 88:26–40 PLoS One. 2016; 11(11): e0166656
Jan 13, 2022•29 min
Avirulence protein factor heterogeneity in multiple mammalian host/pathogen interactions. Dr. Dan Guerra. Authentic Biochemistry Production.11.Jan.2022
References International Journal of Pharmacy and Pharmaceutical Sciences 2015 7(9):20-29 PLoS One. 2016; 11(11): e0166656. PLoS Pathog. 2019 Nov15;15(11):e1007687 Clin Microbiol Rev. 2006 Oct;19(4):728-62 Expert Rev Vaccines. 2009 Apr;8(4):447-54 Front. Microbiol., 14 July 2021
Jan 12, 2022•30 min
Avirulence in the Streptococci and the Two-Component System of Histidine Kinase and Response Regulator. II. DJGPhD. Authentic Biochemistry 09Jan2022
References Front. Microbiol., 14 July 2021 PLoS One. 2016; 11(11): e0166656. The Lancet Microbe 2021; 2(7 ) Pages e291-e299
Jan 10, 2022•30 min
Avirulence and the mechanisms of pathobiochemistry I. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production. 08.Jan 2022
Reference Front. Microbiol., 14 July 2021
Jan 09, 2022•30 min
The neuronal porosomal and synaptosomal structural anatomy as a product of membrane lipid vesicular trafficking, Dr. Daniel J. Guerra Authentic Biochemistry. 05 January 2022
PLoS One. 2015 Jan 21;10(1):e0116919. Neurochem Res. 2015 Jan;40(1):59-69 Physiology. 2009. Volume 24 Issue 6 : 367-376
Jan 06, 2022•30 min
The bioenergetic glucose sensing network of the appetitive reward pathway is linked to the periphery via the neuroendocrine system. DJGPhD. Authentic Biochemistry. 04.Jan.2022
The human neuroendocrine system is directly regulated and in communication with the autonomic nervous system via cortical and diencephalonomic CNS nuclei. These converging networks coordinate satiety, glycemia, bioenergetics, oxygen transport, dietary input, digestion and muscular activity in direct association with pancreatic insulin/glucagon ratio dynamics. References Molecular Neurobiology volume 56, pages769–796 (2019) Molecular Neurobiology volume 56, pages7950–7965 (2019)...
Jan 05, 2022•29 min
The Motor Neuron Association to Reward Pathway: Motor Neuron Disease , an Introduction. Dr. Daniel J. Guerra. 03 January 2022. Authentic Biochemistry Productions.
Introduction to motor neuron structure/function relationships and the MND's including Amyotrophic Lateral Sclerosis.
Jan 04, 2022•30 min
The CNS and Pandemic Obesity: The Appetitive Reward Pathway, Energy Expenditure, and Neuroendocrine Signaling. DJGPhD. 02.Jan.2022 Authentic Biochemistry Productions.
The CNS processes nutritional (biochemical) signaling from the external and internal environment during and subsequent to dietary ingestion. During the initiation phase, affective (limbic) and executive (PFC/OFC) attention is facilitative toward ingestive behavior linked to appetitive hunger stimulation via neural, visceral, and endocrine networking including memory cues that obtain opportunity to consume pleasurable high caloric density nutrition. Gastroenterology. 2017 May; 152(7): 1728–1738 I...
Jan 02, 2022•30 min
A short Pharmacology lecture on New Year's Day 2022. Dr Daniel J. Guerra. Authentic Biochemistry
Pharmacokinetics are discussed.
Jan 01, 2022•30 min
Appetitive Reward Pathway III.-Neurobiochemistry and Epigenetics of Addiction. DJGPhD. 31.12.21 Authentic Biochemistry
Dopaminenergic pathways are corrupted by addictive behaviors especially the use/abuse of psychoactive drugs that may become behavioral reward saliencies linked to epigenomic modifications.
Dec 31, 2021•30 min
Anhedonic and MDD- Associated Appetitive Reward Pathway Biochemistry and Pathophysiology II. DJGPhD. Authentic Biochemistry.30..12.21.
References Front Neurosci. 2019; 13: 707 Nature Metabolism 2019. 1:754–764 Int. J. Mol. Sci. 2019, 20(6), 1505 Neuropsychiatr Dis Treat. 2015; 11: 875–888 Mol Psychiatry. 2016 Oct; 21(10): 1358–1365.
Dec 31, 2021•30 min
Appetitive Reward Pathway Biochemistry and Neural Circuitry Regulation I. Dr. Daniel J. Guerra. 29.12.21. An Authentic Biochemistry Production.
References Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Front. Neurosci., 26 November 2019
Dec 29, 2021•30 min
AMPK and Immuno-Epigenetic Biochemistry Part 2/2/ DJGPhD. Authentic Biochemistry 27.12.21
J Neuroinflammation. 2019; 16: 34 Nature Cell Biology, 02 Sep 2011, 13(9):1016-1023 Critical Reviews in Clinical Laboratory Sciences Volume 56, 2019 - Issue 7 Pages 472-492
Dec 28, 2021•30 min
AMPK and Immuno-Epigenetic Biochemistry Part 1. Dr. Daniel J. Guerra. 27.12.21. Authentic Biochemistry
References Nat Cell Biol. 2019 Mar; 21(3): 397–407 CELL Volume 126, Issue 3, 11 August 2006, Pages 503-514 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Int J Biol Sci. 2015; 11(11): 1272–1280 Sci Signal. 2017 Jan 31; 10(464): eaaf7478. Front Immunol. 2019; 10: 345. J Neuroinflammation. 2019; 16: 34.
Dec 27, 2021•30 min
AMPK negatively regulates lipogenesis by phosphorylating ACCase 1&2 plus HMGCoA reductase thus supporting beta oxidation of fatty acids . Dr. Daniel J. Guerra. 22.12.21. Authentic Biochemistry
Cell Metabolism 2020 31472-492 Amino Acids. 2012 Oct;43(4):1803-7 Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690
Dec 23, 2021•30 min
AMPK is associated with the POMC vs, NPY neuronal axis under Leptin Control. DJGPhD. 20.12.21 Authentic Biochemistry
References HORMONES 2013, 12(2):172-191 Proc Natl Acad Sci U S A . 2002 Dec 24;99(26):17155-60 Eur J Endocrinol. 2017 176(5): R235–R246.
Dec 21, 2021•30 min
AMPK Allosteric Regulation and Interaction with the Opposing mTORC Network. Part 2. Dr. Daniel J. Guerra. Authentic Biochemistry 19.12.21
Eur J Endocrinol. 2017 176(5): R235–R246 Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690
Dec 20, 2021•30 min
Bio-Molecular Regulator Series . AMPK. Part One. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production.19.12.21.
An introductory lecture on the biomolecular sensor kinase, Adenosyl Mono-Phosphate (protein) Kinase; AMPK. References Mol Genet Metab. 2013 Jul;109(3):260-8 PLoS One. 2016 Aug 16;11(8):e0161252. Experimental & Molecular Medicine volume 48, 224 (2016) Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690
Dec 19, 2021•30 min
T-lymphocyte and macrophage membrane CD38 ecto-enzyme mediated NAD catabolism is associated with ageing and the decline in Sirtuin-mediated deacylase activity. DJGPhD.11.Dec.21' Authentic Biochemistry
References Cell Metabolism. 2016. 23, 1127–1139 Cells 2020, 9(1), 228 Front. Immunol., 31 May 2019 Int J Mol Sci. 2020 Nov; 21(22): 8609 Circ Res. 2018 Sep 14; 123(7): 868–885. Int J Mol Sci. 2019 Mar; 20(5): 1223
Dec 12, 2021•30 min
Aposteriori synthesis of neuroendocrine linked clock chronicity and the Senescent associated Secretory Phenotype through the synthetic apriori lens of NAD+. DJGPhD.10Dec21. Authentic Biochemistry
References Nat Cell Biol. 2019 Mar; 21(3): 397–407 J Diabetes Metab Disord. 2020 Jul 21;19(2):1797-1825 Int. J. Mol. Sci. 2014, 15, 16848-16884
Dec 10, 2021•30 min
How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21
Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppressor genes like p16INK4a while DNA Damage Repair (DDR) from pro-inflammatory cytokine production from senescent cells and Th1 lymphocytes can inhibit commitment to mitosis and cytokinesis by generating the paracrine SASP paradigm. Refs. Am J Physiol Cell Physiol 2012;302:C1026-C1034 Steroids Volume 75, I...
Dec 08, 2021•30 min
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