Dr. Guerra presents: The CNS and the Immune System are linked to Recombination and the Epigenome. Lecture IV. 24.4.21 Authentic Biochemistry

As an hypothetico-deduction,  Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity.

In conjunction with a neutral sphingomyelinase and the subsequent synthesis of diacylglycerol thence promoting activation of a PKC-Zeta, T cell receptor translocation and activation are obtained. 

Prior RAG mediated recombination events in CNS-resident lymphocytes, associated microglia and neurons can lead to recombination event epigenomic ontologies that either promote or curtail a resident hyperimmune response   leading to classical neurodegenerative diseases of the elderly.

References:

J. Biol. Chem. 1998;273:14550-14559

Frontiers in Immunology.2014. 5:100

Front Cell Dev Biol. 2019; 7: 226.