Dr. Guerra explains the ID2 HLH pseudo transcriptional corridor in leukemia and aging. 11 November 2020
Episode description
1.Id proteins are helix-loop-helix (HLH) proteins lacking the basic amino acid domain necessary to bind DNA.and therefore ID functions in a dominant negative manner by sequestering ubiquitously expressed or cell- restricted basic HLH transcription factors: this results in effective blockade of transcription since ID causes a failure of dimerized basic HLH proteins to bind DNA.
2. Id proteins regulate transcription factors that are involved in developmental processes such as myogenesis, neurogenesis, bone morphogenesis, lymphopoiesis hematopoiesis, and myeloid differentiation
3. Id2−/− mice lack lymph nodes and Peyer's patches*,
*Peyer's patches are discrete masses of lymphatic tissue found throughout the ileum of the mammalian small intestine
Oncogene volume 22, pages1–9(2003)
PNAS January 15, 2019 116 (3) 890-899
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