Authentic Biochemistry Podcast. Alzheimer’s Disease coda. Dr Daniel J Guerra.04sept24

Correction:

In my lecture I incorrectly used the W single letter designation as representing tyrosine. I miss-spoke.

W=tryptophan while Y=tyrosine.

The WW domain discussion is important for specific protein:protein interactions wherein the tryptophan (W) residues (found in the beta1 and beta 3 folds) are separated by 20 -22 amino acids that contain certain tyrosine (Y) residues in the beta2 region which may become phosphorylated thus generating phosophotyrosine binding (PTB)domains that are recognized by other proteins.

I apologize for the error.

References

Exp Biol Med (Maywood). 2015 Mar; 240(3):375–382

Cellular Physiology and Biochemistry (2017) 41 (3): 1189–1198.

PNAS 2022 Sep6;119(36):e2204069119

Alzheimer's Research & Therapy.2024.volume 16, Article number: 144 Joel, B. 1977. Vienna [Strangers;lp]

https://open.spotify.com/track/4U45aEWtQhrm8A5mxPaFZ7?si=240c0d811f164b7c

Beethoven, LV. 1816. Seventh Symphony A major. Op92.

https://open.spotify.com/album/2kDHEJxutXleLTNCctvgSB?si=qefvirqXSviiOqPmvWME7w