Authentic Biochemistry Neuroimmune and Epigenetic Interactions in Aging III. DJGPhD 21.4.21
Apr 21, 2021•30 min
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Episode description
Single-nucleotide polymorphisms and copy-number variations (CNV’s) result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in the accumulation of chromosomal variation.
Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene proteins RAG1 & RAG2 that are canonically linked to V(D)J recombination of the T cell receptor and the B cell immunoglobulins.
- FEBS J. 2017 Jun; 284(11): 1590–1605.
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