Welcome to the Architect of Resilience podcast, where we explore the secrets of overcoming life's challenges and unlocking unstoppable strength through deep personal conversations and expert insights. Man, I am so excited today. Biohacking cellular energy for peak performance. The mitochondrial matrix is what we're going to call today. So we often think about mitochondria as the
powerhouse for your cells. But today we're going to dive a lot deeper around the secrets of mitochondria health and optimizing your body's energy systems for better performance, longevity, and well being. We've all heard it before. You know, they're the powerhouse of the cell.
But what if I told you mitochondria are so much more than that? These dynamic cellular structures are critical regulators not just for energy, but also cellular communication, brain function and cognition, immune system response, inflammation control, gene expression, and aging. And when mitochondria become dysfunctional, they play a major role in the progression of numerous disease pathologies from metabolic disorders such as Alzheimer's and Parkinson's, and even conditions like chronic
fatigue and autoimmune dysfunction. So in today's episode, we'll explore three cutting edge compounds that are revolutionizing mitochondrial health. We did a Separate episode on SLU PP332. It's a powerful mitochondrial enhancer that amplifies energy production and reduces oxidative stress, helping cells perform at their peak. And let's not forget, this is an incredibly unique compound because of the. The ERR Alpha receptor that's in every part of
the body. And this allows you to target tissues you'd never be able to do before. So it's a really great product to put in concert with a lot of other interventions to attack so many areas from eyes to brain to organs that you can't hit. We're going to talk about Urothin A. This is pretty popular in the biohacker scene right now. It's a compound that promotes mitophagy, the process of clearing out damaged mitochondria to allow healthier ones to thrive. That's
vital for anti aging and cellular efficiency. The last one you probably haven't heard of before. Bam 15. Remember that name. It's going to be all the rage in a few years from now. This, it's hard to get your hands on. There's very few people. But we're going to talk about that in a bit. But that's because it's so new. But man, it is, it's. It's wild. Uh, it is a potent mitochondrial uncoupler that boosts fat burning, enhances metabolic flexibility and supports energy
balance. But here's the important part. These compounds are incredible on their own, but they must be used. And we're going to talk about this specifically strategically and we'll break down why. And while combining. Why combining the products like SLU, PP332 and BAM15 at the same time or in the same capsule is counterproductive and could
undermine your mitochondrial efficiency. The science behind mitochondrial fission, fusion and cell dynamics, the crucial processes that dictate when mitochondria need to divide, merge and repair themselves. And how to build a comprehensive mitochondrial protocol. So you can do that, that strategic piece that I talked about that leverages these compounds correctly to maximize energy
longevity and metabolic function. So by the end of the episode, I hope you'll have a deeper understanding of why mitochondrial health is the foundation of your well being and how to support it intelligently with these powerful compounds. So, yeah, that's our episode. Let's get rolling. What do you think, Anthony? Welcome to the show. Great to be back on here. I always enjoy our conversations and
that was a perfect intro. Mitochondria are just fascinating topic and I think we're going to have a lot of fun with this today. Yeah. Shall we start with. Do you want to start with the. A little recap on slew? Yeah, maybe even before we get into slu, if it's all right, I think. And this will really kind of set the stage for why there has to be precision with mitochondrial compounds. What can go wrong? And it's really a simple problem that breaks down with a simple
solution. But I think as we kind of dig into this, people really be able to follow along. So if it's okay, I would love to explain to people kind of what happens, you know, what, what are, what are our energy systems we use in mitochondria? And the two primary ones we're going to focus in on are going to be oxidative phosphorylation. And the other one would be glycolysis. And when we think about both of those, you know, they're both, they both have their place. Glycolysis is if we need to burn
energy really, really, really fast. But we're not going to make a whole lot of ATP with that usually like 4 and oxidative phosphorylation, that's when things are humming along. We yield 32 to 36 ATP and that's where we have that metabolic flexibility that allows us to use fats or glucose. And the reason it's Important. The reason I wanted to kind of set the stage with this is to understand what
goes wrong with the mitochondria. It's when we start to have a breakdown in our ability to access that oxidative phosphorylation. Then when we're relying on glucose, things happen. Like we get desensitized to glucose because our body's trying to use it so fast and it starts to cause us to accumulate triglycerides and fats in the liver and we're not efficient at making ATP which our immune system needs, so it creates inflammation in the body.
And with just that little bit, I think if we take a second and kind of think about what's going on here, you know, when we lose that metabolic flexibility in the mitochondria, it's so easy to trace everything back to wow, you know, it's a cellular metabolism issue. And if we just focus on fixing that cellular metabolism, regaining that metabolic flexibility, you know, we can untangle these chronic problems, we can improve performance, we can have sharp brains, all that good
stuff. Let's dive into the world of optimizing your overall health. With pushing my physical limits I encountered significant reductions in my health and I reached out to Merrick Health as the premier telehealth service. I loved their personalized health coaching. From the comfort of my home, they empower you with the choice of self service diagnostic labs or what I chose the guided optimization with expert interpretations of blood work health coaching with medications delivered to my
door. Merrick Health is your partner in optimizing your health. Listeners conceive a fantastic 10% discount off their first blood work with code resilience@merrickhealth.com that's code resilience for 10% off your first blood work at merrickhealth.com Discover the future of health today. Yeah, I think that that's absolutely a great starting point for, for that discussion and to recap that right. It's, it's a crucial
process for our mitochondria where energy. So when we're talking about the oxidative phosphorylation in relation to mitochondrial health. Right. The energy produced from incorrect me if I'm in, if I'm making a mistake on this anymore. But produce from ATP in the final step of combining that electron transport chain is. Is that right? Yeah. And just to unpack that a little bit more so people can follow
the process. That's a perfect recap of it. But this will give us even a little bit, kind of zoom in on it a bit more so we have five different complexes, and the first one, it's the NADH dehydrogenase complex. And that's kind of like the water pump. Basically what it's going to do is it's going to take these electrons from nadh, it's going to use their energy for a proton pump, which is just moving these hydrogen
ions across the mitochondrial membrane. A good way to think about it is it's just like a water pump on a hydroelectric dam. It's moving electrons from NADH and it kind of pumps it uphill. Those protons cross the membrane and that is the beginning of the creation of energy. And kind of a cool side note, you'll remember our episode we did on ketone ester. And when we think about NAD plus to NADH ratio, that's our
redox potential. And what that means is when we wake up in the morning, we want to have a lot of these hydrogen ions available to donate through these complexes. So our mitochondria have the energy so that they can do the things they need to do, maintain metabolic flexibility. So, simple trick, you know, just taking that half a shot of ketone ester before you go to sleep, and you've improved your redox
potential. So then when we move on to complex number two, the cesinate dehydrogenase, it's kind of like a smaller side pump, like a secondary water wheel even. And it doesn't really pump the water uphill directly like complex one. What it does is it feeds water into your system at a slightly lower level. Complex two is going to accept electrons. So remember, complex one, we're donating an electron. Complex two, we're accepting an electron. So it's just kind of like passing a football
or a baton and a relay race. Then complex 3, cytochrome BCE 1, complex passing the buckets along. So just like this relay station or a bucket brigade passing the electrons down the line, it continues to pump the water uphill. These protons are moving uphill now, and it's using the energy released from handling them from one bucket to another until we start to create this potential store of energy. And kind of a cool side note, I just learned this. These protons have got the. It's like a
lightning bolt, the amount of energy that's in them. So I kind of picture like Back to the future, almost like 13,000 gigawatts or whatever. Yep. So then after complex three, we move on to complex four. That's cytochrome C oxidase, and that's kind of the final reservoir to Build on our analogy. And what's happening in this step is electrons are going to be delivered to oxygen. It's just like water flowing downhill in
a reservoir. And complex four is going to safely combine these electrons, oxygen and protons, and that creates water. And that finishes the electron's journey and allows us to. It also contributes to pumping more of these protons kind of uphill and completes that proton gradient. So thinking about our body as that electrical system, this is what's moving those electrons through that system. And then at the end of that electron transport chain,
oxygen acts on the final electron acceptor, right? Combining those electrons and hydrogens to form water. And that final step with oxygen right. In the complex 5. This is, this is like the big grand finale. And that's where we make ATP synthase. And complex 5 is like that turbine placed at the bottom of the dam. And when these protons are flowing back downhill, the turbine kind of spins. It harnesses that energy flowing of electrons.
And a simplified explanation is this spinning turbine that uses stored energy from proton flow, generates ATP. ATP, of course, is our currency of energy. And everything in our body runs on it. So that's kind of a overview of these five complexes, starting with, you know, at night when we do our little ketone ester, creating a supply of hydrogen ions that can be donated into complex one and then accepted in complex two, and so on and so on until we finally make this
amazing ATP. So I think that'll provide some much needed context as we continue our discussion. Yeah, that's fantastic. And then the other side of that, let's talk about the glycolation and mitochondrial health. So glycolation, as you said before, is the. Refers to that process where sugar molecules bond to proteins, fats, DNA without enzymes, without enzyme control, forming harmful compounds known as ages. I know that comes up, that term comes up a lot
in, you know, those. Listen to the biohacker world. But advanced glycolation end products, and this process is accelerated by oxidative stress and mitochondrial dysfunction, both of which contribute to significant aging, chronic disease, and decreased cellular energy. I know I see this quite a bit with clients when we've got hyperlipidemia often. Also combined with, you know, the start of, you know, pre diabetes, they're all linked together with
that inability to process that. So mitochondria, I mean, they're, they're responsible for producing that ATP through the oxidative phosphorylation, like we talked about. But poor mitochondrial function increases oxidative stress, which accelerates that glycolation by forming these ages. And as the efficiency of the mitochondria decline, the cells produce these excessive free
radicals, further driving. So this glycolation process is, you know, it just wants to cycle up because it's damaging the proteins like collagen and elastin, leading to skin aging, cardiovascular issues, cognitive decline. All these things are starting to happen. Kind of a really cool side note to build on that. If you're sitting next to a friend right now, look on the back of their neck. And if you see creases, looks like little cracks in the skin, those are literally associated
glycation end products. And it's a sign that their sugars are kind of spiking and dropping. And exactly what Chris is talking about is going on. So it's a real non invasive, accurate way to measure am I making these associated glycation end products? And if I am like, oh, probably need to think about what I'm doing. Yeah, that's. That's great. So did you want to jump in? Where. Where did you want to jump to next? I think few. The cell
dynamics. Yeah, I think if we talk a little bit about kind of how mitochondria grow, so to speak, like the fission, the fusion, then I think we're going to have a real clear sense of these are what the mitochondrial compounds do. We want to speed this up, we want to slow this down. These go together, and I think it'll really come together nicely. All right, yeah, let's dive into that. I think this is another one
for you to take the lead on. But the science behind mitochondrial fission, fusion, and those cell dynamics and how mitochondria are these dynamic organelles that are constantly undergoing these processes of fission, fusion, and these processes are crucial for maintaining mitochondrial quality control, production, and cellular health. Yeah, absolutely. So mitochondrial fission is acting as an early
sensor of cellular stress. And when we think about cellular stress, like, if we've got like, low calories or oxidative stress or other exogenous factors like toxins, this is going to create mitochondrial fission. And fission essentially is these things are kind of splitting apart during, like, prolonged stress. The mitochondria are going to go undergo this fission. And the mild. When we have a more mild stress, like something we can adapt to, we favor more fusion. And I'll unpack that a
little bit more so it makes sense. So fission, basically what's happening is you've got this mitochondria and it's been working its ass off to keep up with our energy demands. And just like, if we had a power tool, you know, it starts to break down a little bit and that brilliant mitochondria starts to segregate the damaged components. And the reason it does that is so that it kind of can facilitate this mitophagy, which is going to be essentially removing the bad parts and leaving like a better
mitochondria. Then when we think about fusion, what's happening is just kind of like what it sounds. These little mitochondria are fusing together. So you've got two that kind of have like maybe one has like three quarters of a good mitochondria, one has half a good mitochondria. Now they fuse together. You've even got spare parts and you have a better mitochondria. So fusion is really good. We want that to happen.
And as long as that division process is kind of kept under wraps, you know, we're able to essentially have that division, we're able to have that kind of partitioning of bad parts and we're able to join good things together. So that's really our ultimate goal. I, like a gearhead like me, loves the spare parts analogy. But yeah, for mitochondrial quality control, this balance between the fission and fusion, that's what ensures
the mitochondrial health. So fission isolates damage, pairs that off so you know, for degradation, while the fusion, you know, rescues partially damaged mitochondria, allowing them to share components which for healthier mitochondria. And you know, that's why it's so important for mitochondrial health. The efficient, you know, dynamics are crucial for those things that we've talked about. Energy production through ATP synthesis, cellular repair and regeneration,
metabolic function and longevity. And anti aging dysregulation in these processes is going to be linked to aging, neurodegenerative disease, metabolic disorders and cardiovascular issues. And it makes perfect sense when you think about it too, all these things. Essentially what's happening is we've accumulated bad
parts in mitochondria, we don't have enough good mitochondria. So when we have a mitochondria with bad parts, it's not going to be able to effectively maintain that metabolic flexibility that allows it to use oxidative phosphorylation, where we have that significantly higher yield of ATP than glycolysis. And that's what you see in cancer, basically. When we talk about a Warburg effect, it's
where we're more glycolytic. And just to kind of highlight the inefficiency of being in that constantly glycolytic state, you're basically starting with 2 glucose, 2 ATP and you're ending up with 4 ATP. So your, your cell's working a lot harder than it needs to. And kind of on a side note, and this would be a whole nother podcast, but when we think about, and I was guilty of this for years, you know, I skinny kid, wanted to put on muscles. So I'm like mtor, mtor,
mtor. And when we're in that MTOR dominant state, we tend to use glycolysis weight training. You know, it's primarily going to be glycolytic activity. And then when we build those fast twitch muscle fibers that prefer glucose and we have this dominance in our system of things that would are more adept at using glucose, we start to lose that metabolic flexibility. And when we lose that metabolic flexibility, we're under
fueling our immune system. So that's going to create inflammation and we're not really meeting our energy demand. So we start to feel fatigue. Things like our heart, which is the most metabolically demanding tissue in our body, and our brain, which is the second most, they don't have enough energy. So that's where your brain fog comes in. That's where your cardiac events come in. So you can really, really see the importance of just simply
maintaining metabolic flexibility. And again, going back to the ketones, how when we start to tend towards this more glycolytic state, that's a simple intervention where we can start to re establish some metabolic flexibility. And there's a lot more to it than that. But hopefully that gives people a little bit more context and understanding of some of the things we'll be talking about. Yeah, and for reference, without diving into it, the, the ketone that Anthony and I are referencing is beta
hydroxybutyrate. It's sold as KE4. I think there might be some other versions out there as other products as, as well besides that one, but that's the one that you're looking for. Should we dive into then how we remediate this? Yeah, I think it's a perfect opportunity and probably kind of a fun time to jump right in and introduce people to the concept of BAM15, what it is and why it works in a situation like this. So to set the stage, imagine I'd. Like to mention like this discussion around
BAM15. We've, we've been doing this podcast and discussion back and forth now for I don't know, six, eight months, something like that, Anthony, since we first and like the very first call we got on I was like, hey, I want to talk to you About I've got this, you, unique approach to how I subdue some things that, you know, people I've been doing for a long time. And we're talking about some compounds that are, you know, not normally talked
about. And it was a little tentative around bringing it up and, and Anthony's like, yeah, let's talk about that. And so it was a fun discussion. Pretty well came out of it. Yeah. Now here we are, you know, quite some time later, we're going to dive into it now. Yeah. So BAM15 is a mitochondrial uncoupler. And when we think about mitochondrial uncouplers, basically what it is. And this is why I wanted to talk about the different
energy processes. It's going to be a type of compound that disrupts that normal process of ATP production in cells, in particular the mitochondria. And unlike traditional fat burning, compounds that are going to increase the metabolic rate by stimulating the nervous system, like caffeine or epidrine or even slew, increases metabolic rate. BAM15 works at a cellular level, making mitochondria burn more fuel without producing additional ATP. So at first, you know, we start thinking, or at least
I would think, like, didn't we just say we need ATP? Like, how is this a good thing? Well, and it's bypass, it's allowing those protons to bypass this ATP synthase process through the mitochondrial membrane. So that's, that's quite unique. Precisely. Yeah.
The. If we think about the mitochondria as a power plant and their job being to kind of burn fuel, like whether it's glucose or fat, to create the ATP, usually they've got this well organized system where these protons, it's just like what we were describing, are being pumped across this gradient and creating this electrochemical gradient. And what BAM15 does when it uncouples, it makes our mitochondria leak these proteins back across the membrane without
making ATP. And the forces in the mitochondria end up burning even more fuel to restore the lost gradient. So essentially our cell is like, man, you know, we're supposed to be making 36 ATP and we're not making 36. We got to work harder. And when things work harder, we have this increased energy expenditure without stimulation, like caffeine or something like that, that could blood pressure. Essentially it kind of
slows down these, these processes. This gets us back to where fusion is going to be dominant because essentially it's kind of letting our cells, it's an oversimplification, but it's letting our cells kind of get Caught up on clearing out the non working parts in that mitochondria from the rapid fission that was occurring and saying like, all right, let's sort this out, let's get some good parts, let's divide, let's find some other good parts so we can start putting together good mitochondria.
And our body really wants to do that because remember, it's having a really hard time making energy. So it can either create a more efficient energy producing process, the oxidative phosphorylation, but we're cheating it out of electrons, or it can make more mitochondria, mitochondrial biogenesis. So that's kind of the mechanism behind how that ends up working.
Yeah, I should be. We should note that this process generates heat instead of ATP, so that effectively increases the energy expenditure without the additional physical activity as well. And by promoting this mitochondrial uncoupling, as you noted, BAM15 drives the body to burn more calories to maintain its core temperature and metabolic function. But as you noted, unlike stimulants, caffeine, ephedrine, so on, BAM15 doesn't act on the central
nervous system. So what it's going to do is reduce the risk of anxiety, jitteriness, or that cardiovascular strain associated with it, or the demand on the pituitary and the adrenal release over time, which is going to cause some depletion as well. Yeah. And people are probably, they've probably heard of the DNP and I think it's a good opportunity to kind of highlight just some of the nuances that make BAM15 essentially safe. Where DNP can be problematic if you don't know what you're doing.
Yeah, BAM15 is the one that has been used in the human clinical trials and for the sake, like it was developed for the safety profile as it relates. Yeah, the essentially what's happening with the BAM15, it's going to have a high fat burning output because it's shuttling these protons back across the membrane that collapses that proton gradient. And as a result, the mitochondria burn more fat and more glucose to compensate for that lost energy. What's unique about it
is generally uncouplers generate heat. DNP definitely generates heat, so does fccp, which they use in research a lot. But bam, you don't have this increase in body temperature. DNP can affect the heart rate. BAM does not affect the heart rate. As far as toxicity, there's low to no toxicity with bamboo and even at small doses with DNP there's high toxicity. And when we think about Things like diabetes, bam. It shows a lot of promise for
correcting things like diabetes. And that really just kind of comes back to when it collapses that proton gradient, it restores metabolic flexibility. DNP does not have that ability. So BAM is kind of DNP version 2.0. They made it more tissue specific. They took out the excessive dissipation of heat, reduced the half life. So it's a one hour half life. Whereas fully clearing the metabolites from DNP can take up to 36 hours. So those can accumulate and essentially create a
greater uncoupling. And it works. ENP works on more uncoupling proteins than BAM does. So you have uncoupling proteins in your brain, your heart, all different tissues. BAM is a little more tissue specific. So really kind of a cool, cool compound. Yeah, yeah. The, the research on the metabolic syndrome, the type 2 diabetes is really, really fascinating with, it relates to BAM15 and with the
fat loss component. The research on fatty liver is also really, really interesting as well, being able to target and remove the, the, the fat in that area as well. And thank you for the correction on the, the heat dissipation as it relates to BAM15 on that. The. Yeah, it's really interesting because uncouplers, I mean, if we're losing an electron, it should
increase heat, but for some reason it doesn't. And my theory on that is because it doesn't hit the broad spectrum of uncoupling proteins that DNP does. But honestly, I don't have an answer, so that'll be something fun for me to read about. Yeah, yeah. And when we talk about the, the research and the impact on the type 2 by diabetes, I think it's important to note that it really does effectively reduce the visceral fat, which is the dangerous type linked to these metabolic
disorders as well. And that is one of the, you know, it is hard to target that, that area and that's, that's really impactful. Yeah, there was a really interesting study they did where they compared BAM 15 FCCP. The GLP1s looked at weight loss and BAM outperformed them by 23%. Now there's no effects on digestion, no effects on suppressing hunger, anything like that. This is all just happening at a metabolic level. And that's a
hard concept sometimes for people to kind of get their head around. They're like, you know, we're so conditioned to think we need to eat less to lose weight, but once we really. And that's why I'm so fascinated by learning about different energy systems and how to turn them on and off. Once we understand those dynamics, we can see, you know, it starts to fill in the blanks for like, how do we have these people that say they're eating 5,000 calories and they're, you
know, pardon my English, but dick skin lean. And then they have these people that are eating 800 calories and it looks like you could roll them down a hill. And it just kind of comes back to again, the metabolic flexibility, understanding how we make energy and a healthy mitochondria. Yeah, so you noted the GLP. So obviously GLPs are really popular for fat loss and there's a lot of other health benefits. We've got an entire episode on those, so I won't recap that, but really, really
fascinating. But they do work on the weight loss side simply through crushing the, the appetite if you take them at the higher dose. Now, there is some impact on metabolic and cardiovascular. Again, don't need to go there. But one of the areas that's unique with BAM15 is the impact on preserving lean muscle
mass as well. So we've got preserving lean muscle mass, improving metabolic flexibility, reducing visceral fat, improving metabolic disorders like reducing oxidative stress, and repairing your mitochondrial tissue through that fusion process. Like, that's, that's. I mean, that's just a fascinating, amazing
compound. Yeah, absolutely. And what's really cool, now that we kind of have an understanding of it, we can start to kind of piece together, you know, how we can leverage this in a training program. The. If we think about on days that we're working out, basically, we want to have that high energy production, we want to ramp up that, that engine, and we want to have mitochondria really, really, really
working hard. So that on a day that we're working out, slu makes perfect sense that essentially we're increasing the amount of ATP we're producing and we're increasing the amount of ATP we're using. So it's basically a futile cycle. But that increases the cell's capacity to make and use energy. And because of that, there's a stimulus for mitochondrial biogenesis. The cells like, man, you know, I'm humming along, but I'm really not gaining any more ATP than I was.
Like, I need more mitochondria. So that's going to kind of accelerate that rate of mitochondria cleaning house, splitting up and make more parts available. Now then, on the day that we're not training that repair day after we've sent that inflammatory response, then that's when we want to have that quality control. That's when we want to slow those processes down. And that's exactly what BAM does.
It slows things down. So we have time to make sure that we're getting rid of all the mitochondrial garbage and we have time to fuse the good mitochondria together. So now we have this army of just awesome mitochondria. Rinse and repeat. We go to the gym the next day and we use our slew. That's going to really work those mitochondria, make them on a divide and then quality control the day after. So that is a very easy strategy to follow. Slew days of training, ramp that up. Better ATP
energy production, and BAM. 15 on the off days, move the other direction. How. Would you employ the urolithin A with this protocol? And what are the benefits of that? Yeah, urolithin A is a fascinating compound. So kind of a little bit about it. Urolithin A, it's naturally derived metabolite and it comes from dietary polyphenols. They're called ilogatinins. And they're found in things like if we eat pomegranate or walnuts or berries.
And what's interesting about these is if you think about these ilagitinins as precursor molecules in certain fruits and nuts, when you eat them, what happens is the bacteria are. Microbiome are going to digest these and they convert olegic acid to urolithins, primarily urolithin A. And then that's going to be absorbed and it's going to be circulated. But here's the interesting part. Not everybody can produce urlithin A. And the reason for that, it
comes down to microbial diversity. Some people have, you know, not good gut health. And that's why, you know, so many people, I mean, it's. It's almost cliche these days, but, like, fix your gut, it's at the core of everything. And this is a perfect example of that. The biggest claim to fame, when we think about, like, what can urlithon A offer is it enhances our mitochondrial health through that mitophagy. And mitophagy is the body's way of removing these old, damaged mitochondria
and replacing them with new healthy ones. So urolithin A really simply boosts mitophagy. And just another way to say it's just selectively recycling damaged or dysfunctional mitochondria is the way I think about it. Just, it's a recycling process. Yep. And when we think about when is this going to be the most beneficial? So let's think about what we put together so far. We know on training days we'd be using slu and that's going to be rapid division, a lot of
garbage produced, hint, hint. Then on our repairing days where things are able to kind of slow that process down and we've got that quality control, main thing we gotta mitigate is gonna be excessive oxidative stress from the previous day. So something like a CoQ10, hint, hint, or a debenone makes perfect sense. So when we think about kind of now, you know, painting the landscape for how can we
really maximize some of these mitochondrial compounds? How can we put them together and make sure they're, we're getting the most out of them and we've got these, this robust alliance of healthy mitochondria. It makes, makes a lot of sense why on days where we're training, we're doing the slew, the urolithin, then we have our rest days, we're doing our BAM and CoQ10, maybe some Alpha lipoic acid. And that simple strategy, you're really going to be maximizing mitochondrial
biogenesis. You're going to be having mitophagy where you're clearing out the bad parts. You're going to have quality control so you're dominant infusion, not fission. And then, you know, we can even talk about what can we do to take it to the next level. We already mentioned the ketone esters the night before. To maximize redox potential. Some other simple things we can do, and we've covered these in previous podcasts, are things like 5amino, 1 MQ or 1 MNA that are going to decrease the
NNMT enzyme. So we have more electrons available for these new healthy mitochondria that we've been making. And we can use things like carnitine that's going to help shuttle fat to the cell so that we can burn more of it and prevent, you know, that accumulation of triglycerides intramuscularly and in the liver. And yeah, we're, we're
really shaping up to have a pretty good protocol here. Yeah, yeah, the acetylly now carnitine, carnitine, really, really valuable in that process for, you know, we're freeing up with, you're doing this, you're, you're, you're increasing, you know, those fats in that bloodstream from all those processes. And now we want to shuttle and drive that to your muscle. The carnitine is really powerful for that. Does a
bunch of other things besides upregulating angiogen receptors and so on. I'm a huge proponent of it. Should probably have a separate discussion at some point. I really love to mix with that vasoblitz because then we're also creating the volume of movement of fluids into the tissue, into the muscle and training. So on your training days, you know that, that, that, that, that carnitine and then the vasoblitz.
If you're doing this protocol, absolutely, you're gonna have just some, your workouts, you're just gonna have this pump and just feel amazing. Alright guys, we talk a lot about mental resilience on this podcast, but let's talk about another type of resilience. That's movement resilience. We want to move well, recover better and do it for life. And it starts with your feet. And you can start today with Naboso. Naboso is a
sensory technology company founded by a functional podiatrist. And all their products feature a texture to stimulate, strengthen and awaken your feet. I use their splay toe spacers and neuroball to release my feet at the end of every day. They also have these textured recovery socks that feel like a mini massage when you walk around. If you're looking for an effective way to bulletproof your feet, head to nemoso.com that's n a b o s o.com and use code resilience for 20% off.
And guess what? You're burning off all this bad stuff in your body. And you know, on a side note, just to add to that and why vasoblitz is such a good choice. And I stand corrected. Previously, when we had discussed methylene blue, I was, I was big on it and Dr. Seeds educated me on why that's not a good idea. So I think it's really worth talking about. And I think this will really underscore the importance of having a Vasa blitz in there
and other things to boost nitric oxide. So when you take methylene blue, essentially what you're doing, you recall we talked about those complexes, you're able to, it can work as a reducing or an oxidizing agent, so it can kind of hop over those first two complexes. Sounds like a good thing. Easier to make energy. Here's the problem. It inhibits way upstream the ability to make nitric oxide. And when we don't have nitric
oxide, everything takes a hit. That's going to be our endothelial cells like our, it's going to be our heart, our brain, our muscles, we need to have nitric oxide. So hold up on that methylene blue. Unless you're recovering from like a Covid or something. I am so glad to hear you say this, Anthony. I have been, I've been struggling with this. Everybody on the methylene blue train, I'm like, I just can't get on board with this because of the, the impact of
nitrogen oxide. I'm like, if you want to have that uptake of those photons through life, there's a lot of, through light. There's so many other ways to, to do that where you've got natural compounds, unlike this chemical methylene blue, that comes out of the industrial realm, you know, like I use ghku. Hey, guess what, it's blue too, by the way. Doing some red light therapy, like, you'll notice the effects, you'll see your HRV values come down. All of that. I think that there's other ways
to do this. There's times and times and places for that methylene blue. But the methylene blue is the answer, I just think is the wrong approach. Which is why, you know, I promote those products that have that, that the nitrogen response in them. So yeah, I really, really great to hear you on track with that this morning. No, I, again, I stand corrected because I was, when I first learned about methylene blue and I was just looking at the complexes and
thinking like this is efficient. It increases absorption of red light. Who wouldn't want that? But fortunately, Dr. Seeds corrected me on that and I've been standing on my podium and yelling as loud as I can, please stop taking methylene blue. Lean on things that are going to improve nitric oxide like your Vasa blitz or citrulline or arginine alpha ketoglutarate. Yeah, that's all that, that's all the stuff that's in there. So, yes, lean on those and give the GHKU a try
before your red light and let me know what you think. Yeah, I love the thought of using the ghk. That's brilliant. So, yeah, the urolithin A, just to recap that, best known for its ability to stimulate mitophage recycling, as I noted, damaging dysfunctional mitochondria. By clearing out inefficient mitochondria and encouraging production of healthier ones, Urolithin A improves energy efficiency and cellular
performance. This effect is particularly important in those individuals with metabolic dysfunction, fatigue and just that, age related mitochondrial decline, which is why it's been so popular in the biohacking community. Those impacts are going to be anti aging and longevity. It's really noted for the improved exercise performance like the recovery and lack of soreness post from post exercise is something that you can definitely see. As noted cognitive support.
Those mitochondrial boosting effects extend to the brain cells with improved energy production helping cognitive clarity, overall mental performance and anti inflammatory properties to reduce neuroinflammation contributing to to cognitive decline. And then the anti inflammatory properties and cellular protection those are strong. By reducing those and the oxidative stress it supports tissue from damage and supports
recovery. I guess I already hit on that with. You can literally feel that with the the less soreness post exercise. So metabolic cardiovascular concerns it's going to have an impact on that. So the strategy though is important and that's what I hope people can take away from this. These compounds aren't
necessarily an everyday product. If you want to combine them together and get the best of all these worlds doing them in this fashion where you've got your ural thin A and your SLU PP on your training days, ramping that up. Then you've got your BAM 15 CoQ 10 the Alpha Lipic acid, things like that on your off days. Really great strategy and you're going to be amazed with the results with this absolutely phenomenal compound. And don't forget some some carnitine always a go to some
vaso blitz. Throw that in on your training. You're going to love it. And people that really want to take it to the next level that beta hydroxybutyrate the ketones just a small bit before bed, some in the morning on your, you know when you're fasted or before or during training. Absolutely phenomenal. And if I could add a couple more nuggets in there like if you really want to take this to the next level.
Again thinking about the mitochondrial peptides that we know about like AMAT C which is an exercise mimetic and SS31 which is going to stabilize cardiolipin. I was thinking about mentioning those two but I want to get to too many things out there because we also mentioned the 5Amino 1 MQ. The 5Amino 1 MQ. Would you use that still daily with this protocol? So I used to use it daily and there's nothing wrong with that at all. What I've switched to is on days that I'm training I use the
5amino 1 MQ. Days that I don't train I use 1 MNA. The reason reason for that is 1 MNA reduces inflammation in the endothelial tissue. So again We've got our anti inflammatory stuff on that non training day to accelerate the recovery process and both of those are a great way to increase NAD without having to worry about feeding the wrong cells. But there's not a deficit like if you mix the SLU and the BAM together. If you did a everyday type approach the so the, the one mq
the. The five amino one MQ you could do every day. Yep. Yeah. The what you wouldn't want to do is BAM and slew in the same capsule at the same time. You're going to be dissipating a ton of electrons and that will generate excess heat and you're negating the benefits of both of them. One of them is trying to speed you up, the other one's trying to slow you down and it's like having your car in neutral and
pushing down the gas all the way. Like you're going to burn crap ton of gas and you're not going to go anywhere and you're going to ruin your engine which is separate those apart. So the day apart works but let's say somebody's training in an evening and then next day in the morning. Like what is just from a you know, a time fence standpoint. Yeah. So the beauty of it is both of
them have a really short half life. As long as you're doing them kind of an every other day thing, you're not going to run into any problems there. The Ideally, you know, 24 hours but with Bam only having a one hour half life and being fairly tissue specific and slew I think I'd have to look it up. I really don't know off the top of my head but I think it's six hours. You're. You'd be fine. There should be enough clearance even if you worked out in the evening and then next day for
recovery. Took your. Took your bam. Nice. The last thing that and I don't mean to overwhelm people with stuff but this is just such a cool compound. It's going to protect your kidneys, it's going to protect your heart. If you're Apoe4 it crosses the blood brain barrier so helps with accumulation of harmful byproducts from fat metabolism in the brain. And it's a PPAR gamma agonist which means it's going to signal your cell to use more fat for an energy. So there's
a lot of synergy with the compounds we've talked about. And ready for this drum roll. Telemacerton that Yep, that makes sense. I what's the dosage that, is it 10? So you could go as low as 20 milligrams twice a day. It comes in up to an 80 milligram tablet, depending on if you're. If you've got, like, kidney issues or high blood pressure, they might put you on a higher dose, but as little as 20 milligrams. You should see
the benefits with the PPARY signaling. And I'd even go so far as to call it a longevity compound. You would need to get a prescription for that from your doctor, but I don't think they'd have any problem writing for that one, especially with all the literature that's coming out for its neuroprotective benefits and protection for the kidneys and all that good stuff. Yeah, I take that. Me, too. Yeah. All right. This has been absolutely so much fun.
I don't know if we should do a recap. I feel we've kind of recapped things a bit. Oh, yeah. Important. We talked about. BAM15 is hard to find, Right. Well, you can find that somewhere, right? Indeed. Yes. Yes. Go to Christmas should hopefully be up by the time this podcast posts. We'll try to get that time together so that it's available. We do have. We do have the COAS posted for all
of the. The SLU and the BAM 15, which, if you're buying from any source, please check and make sure that they've got that available, because we've definitely seen some potency issues with some of the products available on the market. So, yeah, I think you'll be happy. Go check it out. And
if you. Yeah, if you don't want to try it, that's cool, too. But we love trying to talk about fascinating things, and if it's something that we truly believe in, and it's hard to come by trying to make those available to our audience in a high quality, controlled manner that you can trust. Anything that you'd like to add today? No, as. As always,
I love our conversations. I think this is such a cool topic, mitochondria, and we're really just kind of scratching the surface for future of health performance when we get into the mitochondria stuff, you know, having these compounds available, if you're using them responsibly, of course, and strategically, you really have an awesome toolbox where you can get that fat loss, get that boost in performance, and improve your health. So, yeah, just be
strategic. Make sure you're using a good quality product and enjoy the benefits for your mitochondria. Yeah. And if you haven't I need to. Here's our our guest spot for Lift Lab. Amazing. The best as far as the most technologically advanced training program out there that is literally a coach in your pocket with bionic vision watching you, telling you exactly what to load on the bar.
Bar making one of one training programs looking at both your movement, your physiological readiness, which it knows by how fast that bar is moving and adapting the workout specifically to you. Every workout is custom tailored and then the weights are developed for you as you progress finding how your own individual recovery is. There's literally nothing like it. It's the closest thing you can get to hiring me to coach you. So. Yeah, yeah, definitely. Check it out. 29amonth.
You should be able to find a link to that in any of my bio links or kristoffen.com. Yeah, it's really a good investment. I think the challenge people have when they work out from my strength coaching days, it's always how much should I lift or what should I lift? And the app takes the guesswork out of it. It's a smart app, makes training fun, easy, and as Chris said, it's like having a coach in your pocket. Can't say enough good things about it. Yeah. Thank you, sir.