CM#4 Exercise in a Pill? Exploring the Metabolic Magic of SLU-PP-332

Welcome to the architect of Resilience podcast, where we explore the secrets of overcoming life's challenges and unlocking unstoppable strength through deep personal conversations and expert insights. Chris Duffin and Anthony Kastor with you today. We have something very exciting to dive into that probably hardly anybody's heard about, because, one, it's just not available, but actually

it is. Uh, so we'll talk about that later. Uh, we just had a nice warm up on glucose shuttling on another episode that we randomly shot off the. Off our hip. Uh, the. Today, I'm probably going to be doing a little bit more interview fashion, but we're going to be covering a very unique compound. It's a small molecule that is, it's an exercise mimetic, right. And it does this by targeting estrogen related receptors. Errs.

Uh, it's an err panel pan agonist. And that is a group of nuclear receptors involved in regulating energy metabolism. Mitochondrial biogenesis. Actually, I just talked about that with the four hil, uh, uh, compound because there was kind of some overlay and discussion. Uh, and oxidative, uh, metabolism, long and short like this is an incredible product for stripping fat off your body, preserving muscle, and improving metabolic health. So, yeah. Do you want to give us a rundown on the key

mechanisms? Oh, I guess I haven't said what it is. What are we talking about today, Anthony? Yeah, I'm super excited about today's discussion. As Chris said, like, some people may have heard of it, but not really accessible until basically now we're going to be talking about SLU pp 332. And that's not a combination to a lock or a secret code name. It's actually secret code made to some radical fat loss and metabolic health, but. Yeah. Yep, exactly. And you have to have a secret knock to order

it. But other than that, I think maybe before we talk about it, just kind of a quick refresher on the mitochondria is going to make this make a lot of sense. And when we think about our mitochondria and then being so, so crucial, it's kind of like our body's this high performance car, like a Tesla or Bugatti or something. And your choice on that shoot, it could be a Corvette. Mitochondria are going to be the engine. And the better the engine is, the faster and more efficiently your car runs.

And before you ignore your engine maintenance, like the mitochondrial health, you're going to end up running on fumes. And no matter how shiny the exterior looks, when it comes to performance, whether it's crushing it in the gym. Or if we're talking about, like, recovering after a workout or even just living longer. Your mitochondria are basically the unsung heroes of this. And the way that slupp 332 is going to fit into this is a couple different things. It's an exercise memetic,

which is fascinating in and of itself. We'll talk about that a little bit, and basically what that means. Exercise memetics can essentially mimic some of the effects of exercise without having to do the actual workout. So, kind of imagine, like, you're getting some of the benefits of a jog while you're binge watching Netflix. I know for a lot of people, that probably sounds pretty, pretty appealing, and at the same time, it's like, well, how can I

do that? And definitely, it's doing that by causing an increase in the mitochondrial function and enhancing energy expenditure. So just like going for a jog would, right. And in essence, doing a set of bench press is going to do the same thing, but it's clearly not going to do. The effect of the other aspects of doing a bench press workout are going to be. So when we say s exercise mimedic, we're talking about the enhanced energy expenditure of a workout. Yeah. And it

definitely doesn't take the place of working out. It's just something that if you're already doing the right things in the gym, it's going to improve your. Your results and all that good stuff. As you mentioned, Chris, it's going to boost the mitochondrial function. And I also helps with mitochondrial biogenesis. What that means when we think about biogenesis, you're creating more mitochondria.

And when we do this, since each of those, as we recall, are essentially like the horsepower of the engine of our car, now we've got two engines in that Bugatti instead of one. So it's going to be even faster and perform even better. And scientists are getting really excited about this one. It's going to have application for metabolic disorders, muscle atrophy, cognitive decline. It's

almost like they found a way to biohack ourselves. I hate to use that word, but we're really on the cusp of something great. Every time I hear somebody say biohack, I think of Dave Asprey without his shirt off in his office, crunching. So his abs are flexed, but he's got this weird look like this. You know what I'm talking about? Sorry. No, I know

exactly what you're talking about. And I get the same visual. I think that's probably why I don't like the word, I think, to maybe help people understand, like when we talk about exercise, memetic, sort of what's happening on a cellular level, if we kind of break it down, might put a little bit more context to it. So the first thing is AMPK, and that's going to be like the Amp activated protein

kinase. And the way to think about that is Ampk is like the cell's energy gauge and it's going to be activated if the cell senses low energy. So like higher levels of ampk compared to ATP, adenosine monophosphate one compared to adenosine triphosphate three. And that's something that happens, like during exercise because we're using up that ATP. And when you work out, energy stores are going to be depleted and AMPK gets switched on and tells your cells to generate more ATP by burning

fat. This is going to also help with increasing glucose uptake, enhancing mitochondrial function. And it's almost like putting your cells in this energy efficient mode. And the way that SLU PP 332 mimics it is it directly activates this amPk, even without exercise, and it makes the cell think that it's on this low

energy. So this is going to cause the cell to react as if it's in a state of this, like, whoa, I'm exercising, you know, I don't have enough energy here and it's going to improve those metabolic processes and energy production, almost like a survival mechanism. Let's dive into the world of optimizing your overall health. With pushing my physical limits, I encountered significant reductions in my health and I reached out to Merrick Health as the premier telehealth service. I loved their

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code resilience for 10% off. So with that, we had another discussion where we're talking about that and that relation to, to mtor as well. Is there some timing that we need to think about with the use of this for impacting, uh, uh, mtor and muscle protein synthesis? Because obviously the energy sensing. So sensing this low energy levels is going to help improve the mitochondrial function using inner, you know, using those resources. So it's going to help

with body composition, right. We're going to get leaner, we're going to retain muscle mass, but at the same time, if. If we have mtor shutdown, we're not going to be able to add muscle mass quite as, uh, effectively, uh, you know, because muscle protein synthesis requires massive amounts of energy. And so when we. When the cell sense low energy like that processes is essentially kind of shuttled. Yeah, no, that's a really good point. And the research is

pretty new on this. Most of what you're going to find is going to be n of one, where people are reporting their experience with it, and we'll get into some of that or a lot of animal data. Personally, my thoughts are it would be something I'd use in the morning and then prior to a workout, probably about an hour before, some other things it does. And this will kind of explain my timing behind

it. Well, first, I just. I would put the caveat that anybody using this is probably doing some sort of hormonal optimization as a whole anyway, which then would kind of counter those effects as well. Right. If you're doing some things to, you know, stimulate growth hormone relief, release or maintain estrogen levels or some sort of, you know, hormonal enhancement, it became pretty irrelevant. Just like, you know, in prior discussion, we talked about, you know, bodybuilders,

professional bodybuilders using metformin. We don't seem to be lacking any sort of muscle mass on an IFBB pro using metformin, although at times they still try to, you know, you know, put that at certain times as it relates to, um, to training, but others probably don't, you know, because, again, I having poor energy metabolism. So a bodybuilder may be doing that because they have so much androgens in their system that they've got a level of insulin

resistance developing. And so they may be taking the metformin to counter that or to help with the carb displacement, but similar effects with that as it relates to energy sensing and the ampk signaling side of that, some similar thought processes. So just context, right? Just going context doesn't mean, but something to be aware of. Yeah, one of the things, and this will kind of tie into the mtor that's really cool about the SLU. Pp 332 is it also activates PGC one

alpha. And what that is, it's this master regulator of mitochondrial biogenesis. And it kind of turns the dial up when we need to produce more mitochondria and especially like, during exercise or endurance, endurance training and with that being kind of a regulator. And then the other thing, it does, too, it activates sirtuitin one protein. And when we exercise and, like, nad levels increase, this also activates

sirtuitin one. And those are, again, things that are going to help modulate that mitochondrial function, reduce oxidative stress, and promote the cellular repair. What's unique about it, though, with regards to the mtoR. So that's almost going to bypass a lot of what I'm talking about, because it's going to create some of those same effects again, like a hormonal would with preserving or growing muscle tissue, especially mitochondrial biogenesis.

Yeah. When we think about, like, mtor being kind of the pathway that regulates the cell growth, protein synthesis, muscle building, all that good stuff. And then, of course, with exercise, you know, we're activating that mtor pathway, and the slupp 332 actually mimics it. And the way that it does this is kind of unique. It does this through endurance based pathways like the AMPK and PGC One Alpha.

And it's kind of an indirect effect on energy balance, which interacts with the mTOR and promotes better recovery and health, kind of to untangle that, because I know that's kind of a complicated explanation if you think about an endurance runner. And obviously, you know, they're not massive muscle or anything, but by running, they're going to build muscle. So. And that comes through, like, an mtor activation, even though they're primarily

ampk. So when we look at how slupp 332 is working indirectly, you're getting kind of that same mtor stimulation that you'd see in an endurance athlete. And I don't want people to read too much into that, like, oh, man, it's going to build slow twitch fibers or whatever. No, it's just there's kind of more than. More than one way to get to the same end. So by taking this indirect route to

stimulate the mtor, you're kind of getting the best of both worlds. You're getting the improved energy metabolism and activation of the PGC one output, which is going to kind of regulate everything. And you're getting the mtor signaling as well. Wow, that's pretty wild. That makes that just substantially different than anything else that we've talked about in these classes. Yeah, that's. Yeah,

that's amazing. Truly unique. Yeah. The other thing that it does, it's kind of interesting, is, like, with the calcium signaling. So calcium ions are going to act like signaling molecules in a lot of cellular processes. Like, when we think about muscle contraction or mitochondrial function. And during exercise, these calcium levels kind of fluctuate, and this signals the mitochondria to increase energy

production. So it's meeting that higher demand as it's sensing, like, these fluctuations in calcium. What slupp 332 does is it can affect the calcium signaling pathway, and it's kind of cool. It tricks these cells into thinking they're in an exercise state, and then this is going to lead to enhanced mitochondrial activity and energy output. So, essentially to kind of unpack that when we're thinking about every time we contract our

muscle. And I just kind of imagine, like, this tidal wave of calcium going up

and down, and our body trying to make heads or sense of that, or heads or tails of that and draw some sense from it. The SLU essentially is kind of telling the body what's happening. Like, all right, you know, we need a little bit more energy. Calcium is doing this. And so just kind of another way it's supporting that plays into that exercise memetic effect that we're talking about.

Then the final thing that's super important to mention is its effect on reactive oxygen species and the antioxidant process. So we know, like, when we exercise, we want to have a certain amount of oxidative stress. And Chris and I just talked about it and not too long ago, and he pointed out that, and I agree 100%, that if you put out the flame, the oxidation too soon after the workout, you don't stimulate that inflammation. Essentially,

you're just putting a wet blanket over your gains. So we want to have those, but the key is we want to be able to kind of switch that off when we need to. And these reactive oxygen species are basically byproducts of mitochondrial activity, and they can cause oxidative damage if they're left unchecked. So during your workout, your cells basically are going to generate more of these, and it's going to allow them to become more resilient. They start producing antioxidants like

glutathione. And that kind of improves the cellular process. So what the SLU does is it increases the mitochondrial activity and energy production, and it increases reactive oxygen species production in a controlled way. And that's the key in a controlled way, and that stimulates the cell's antioxidant defense. So essentially, it's not letting too much out that we're getting those reactive oxygen species, but it's letting enough that we're maximizing or that we can kind of calibrate

our glutathione production. So we're putting out just enough of that fire, but still getting the signal to adapt and make progress. And then the other mechanism of action, and this is one of my favorite areas to kind of look into uncoupling proteins. And basically what those are, an uncoupling protein is just going to allow protons to kind of leak across the mitochondrial membrane. And when that happens, this regulates heat production and

metabolism. Exercise itself is going to induce mild uncoupling in the mitochondria. And when it does that, because essentially the cell is looking for energy, it's becoming less efficient at producing that ATP we talked about. And because of that, because it's like, shoot, which energy system do I use? Glycolysis, lipolysis, oxidative phosphorylation, whatever. It's going to create metabolic flexibility and help burn fat.

And it looks like, at least in preliminary research, that slupp might influence these uncoupling proteins. And by doing so, it's kind of enhancing that energy expenditure. So now that you kind of understand the mechanisms behind it, I think you can kind of see, like, oh, you know, so when we talk about exercise memetic, these are basically the seven things that

are going on. These are the checkpoints that would normally happen when we exercise, and these are the things that we adapt to when we see improvement in performance or body composition or whatever. Can you dive a little bit deeper into explaining to me if it's an uncoupler? So an uncoupler is essentially burning energy by forcing the mitochondria to work less efficiently, but at the same time, it's causing mitochondrial biogenesis and improvement.

Walk me through that again. And then are we also seeing thermogenesis as it relates to this and to what level? Because if we get into some well known uncouplers, like DNP. DNP causes uncoupling in cells throughout the body, which causes a massive amount of thermogenesis and creates a very significant health risk as it relates to that, versus a targeted uncoupling, which is if that is able to do that, that's just mind blowing. Like

that is available, right? Yeah, no, that's a really good question, and I think definitely try to explain this a little bit better. So when we think about what's happening, like, with an uncoupling reaction, and we talk about, like, a proton leak across a mitochondrial membrane, essentially we're losing the ability to create as much ATP.

So our cell, and this is kind of a oversimplification of it, but the cell kind of just like somebody would if, you know, we were getting overwhelmed at work, you know, they start to sweat a little bit, they start to panic, and pretty soon they're like, man, I'm not going to get all this done. So I need to call in one of my coworkers. Shoot, I need to call in three of my coworkers. And that's kind of that

mitochondrial biogenesis. So as the cell senses that there's a demand for energy being placed upon it from the exercise or even just the signal that's coming from the slupp, and it starts to realize it's had to switch to a less efficient energy producing system and that it's still having a tough time keeping up. Next thing it's going to do is like, oh, you know what? I just need more help. So it's going to. That's the mitochondrial biogenesis we see when there's an

uncoupling reaction. Essentially, the cells are so intelligent, and they just realize that this isn't a one man job. We're going to need two, we're going to need four, we're going to need 816. We just need a lot of mitochondria. Does that kind of explain it a little bit better? Yeah, I can see why people are seeing incredible results with this product. We've got, it. Slew is signaling that, you know, we're exercising, we need to. Yeah, yeah, the slew is signaling

that we're exercising. We need to recruit a bunch of cells. At the same time, it's making those cells produce or use a lot more energy than, than, than they normally would. And at the same time, we've got this signaling that's also going to impact positively muscle tissue. Um, I mean, this is like, those mechanisms are just absolutely incredible. I don't. Hopefully I didn't misspeak on that. You know, my, my quick, you know, 15 2nd summary of, of that. No, I think that was perfect. And the

other thing, I think that is worth clearing up for people. When we look at SLU, pp 332 and we call it an estrogen related receptor alpha agonist. And of course, the first thing people are going to hear is estrogen. And in the traditional sense, like, well, shoot, why would I want more estrogen if my goal is to improve performance, not cry? If I have to watch rom.com with my girlfriend and whatever, an estrogen related receptor is going to be a little bit different.

They're called that because of their structure. They're similar in terms of structure to what an estrogen receptor would look like. But the way they work, what they are, is just completely different. Not related to hormones at all.

They're part of a family that's considered to be nuclear receptors. Nuclear receptors essentially are things within the nucleus of a cell that regulate genes, and in this case, specifically, genes linked to energy production, metabolism. I call them kind of switchboard operators for how your cell is going to create and manage energy. And with the SLU PP, I'm just going to start calling it slew, because that's a

mouthful. With the slew, when it activates this erra estrogen related receptor alpha agonist, it's kind of like flipping this master switch on a power plant. And once that switch gets flipped, there's this whole cascade of metabolic processes that are going to start rolling and supercharging your mitochondria's ability to create energy. It's just like turning on turbo mode in your

mitochondria. So when we think about these erras, let's try to think about them in the context of just kind of being a nuclear receptor that's going to accelerate energy production, mitochondrial biogenesis, and all these things we're really kind of going after. Yeah. So let's, let's talk real world. What results have you seen from this, both personally or with people using this product? Because it is hard to come by, but, yeah, it is available to people in the, in the know, I guess. Yeah.

Well said. I've got some experience with it, and I really. It's interesting. So the first time I ordered it, I got it. And when you do the conversion of animal to human and basing a dose on that, I always, especially on something where obviously it looks really safe on paper, but when we're talking about nuclear receptors in the nucleus, it's serious business and we want to be pretty conservative. So I started at 100 micrograms and I. 100 micrograms. You know, I honestly didn't notice a

whole lot. And then I went up to 200 micrograms and still wasn't really overwhelmed, went through that bottle, and then a month or two goes by and one of the other vendors had it available and was like, yeah, you know what? Give it a shot. So 100 micrograms morning, 100 micrograms in pre workout and night and day. I'm telling you, like, within ten days, I had people asking me, like, are you dieting for something?

I'm like, I'm 52 years old. Like, I'm not dieting for anything, but keeping my fiance around and not having to buy a larger shirt. So my belly doesn't hang out. And, I mean, it was really awesome. And I think kind of what that speaks to is, like, you know, there's going to be these places popping up that are going to say, hey, we got slu. And, you know, just do your research on the companies. Make sure it's a real stuff, if it's a real stuff, and if one. My experience is it really works and it

works well. No negative effects. You know, I get my labs run regularly, and I'm probably a little OCD about monitoring my health. Biometrics and everything. A little OCD. All right, a lot of OCD. In fact, there's probably nobody more OCD than me. But nothing but good stuff came from it. Like, I saw a two point jump in my HRV, which doesn't sound significant, but my HRV is, like, always rock bottom. So for it to go up two points, I mean, it's like, even thought I stuck both fingers in a light

socket. I mean, it's. That was awesome. And definitely, like, I mean, just, you know, I think probably everybody does it. You wake up first thing in the morning, eyes are a little puffy, go in front of the mirror, quick check, you know, like, how do I look? How do I feel? And, like, the inflammation within about three days was down, and within just a little over a week, it was like, wow, you know, haven't changed my diet, haven't changed my training, haven't changed anything except adding this

in. And I was really seeing some noticeable fat loss. So you're suggesting 100 micrograms twice a day and for any length of period or. Yeah. Again, this

is just my personal experience with it. So, you know, always make sure you kind of check your own health stuff out and do your research. But for me, 100 micrograms twice a day. I did that for six weeks, then took six weeks off, and then repeated that again. Same protocol took twelve weeks off, and then this time on, the protocol went up to 200 micrograms in the morning and no

afternoon dose. And that was really more or less happenstance because just with everything currently I'm involved in, it's hard to remember to take an afternoon dose. And I didn't really notice any difference between taking both in the morning or splitting it one on one. And me being me. Even pushed it up to 400 in the morning, and again, no negative effects. In fact, like, one of the things I noticed that was kind of cool as I was starting to feel,

like, a little bit run down. Not in the sense like I got a cold, but just like man, you know. I guess mental fatigue would be the best way to categorize it. It kind of felt like that curtain was lifted and I was right back to normal pace. Detects if you want to build more physical resilience in your life you need to start with a firm foundation.

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uh some of this to compound. Is that correctly? Uh huh. Yeah. We're in the process of kind of putting this together and going to be working through you to kind of get this out and give people the opportunity to check it out. If that's something they're interested in. I think that people are going to be really excited about this. I think they're going to get the same results that I'm getting again with any of these research compounds. It's important to realize they are research

compounds. You know we're not, we're not making a recommendation or anything. You know, always stay on top of your health. But if you're curious like me and this is something you're looking into doing, you know we've tested our initial batch, 99.38% pure and I haven't grown the third arm yet or anything. So. Well I think doing the third party testing

is, is very critical and stuff like this. And that's the problem with you know just picking you know, some of the sites that to buy that off of and not getting because you and I both know people that have purchased that from some sites and it's clearly not either dosed correctly or not. There's nothing in it right. So yeah, yeah, yeah. So long and short. Anthony and I are working on formulating an entire peptide line that is orally

bioavailable. We really believe in peptides and their implications for being able to really vastly change the quality of health as well as individual performance. And so this product is something that we're bringing out, making available so that we can fund the significant amount of efforts that have to go into developing the formulation and bringing this to market. So if you want to find out more, find out where to get it, go to chrisduffin.com.

join the private, join the community. And you'll have details on where this is available. So yeah. Anything to add on that? No, just really exciting stuff. And I'm so excited about the formulas we're working on, the compounds we're going to be introducing. There's some real game changers. We're really living in a time where, you know, science is moving at the speed of thought and the possibilities we have to improve people's health, performance

and outcomes. You know, the, nothing's ever going to replace the importance of, you know, getting your rest, training, good nutrition, hydrating, you know, the basics.

But yeah, we're speaking to and it's like I don't, you know, I try to draw it back and make sure people know that that's absolutely foundational that we recommend like get your sleep, get your training, get your, you know, take care of having good, you know, a diverse set of foods, uh, you know, fundamentals. But obviously you know I don't, it's pretty hard to I think criticize us because our audience is people that

are doing those things to begin with. And so you know, constantly having to remind that that's day one game like things that you need to have mastered and be mastering for years before you ever, you know, look at you know, adding anything like this. But it's incredibly exciting. We are super excited. I've been in this space dealing with peptides for 19 years. Actually might have been around 2003. Somewhere in 2003, 2005 I started getting involved. So I incredibly passionate and

excited about this. We're also getting involved in some clinical trials on peptides as well. So just tremendous stuff. Sorry to interrupt you Anthony but we'd love for you know, everyone to be a part of that in some ways. So please you know, join the group and if you can support with you know, testing out some of things like this. I can't wait to get my hands on some sloop. Yeah it's really a

game changer. And you know if you guys have some questions about this because I'm sure wheels are probably turning. Questions are going to come up. Just a quick plug for Chris's community. It's amazing. You know it's a great group of people and there's people from all walks of life, all different backgrounds and everybody's just a wealth of knowledge. Everybody's really excited to help other people and I'm on there answering questions. Chris is on there answering questions, everybody on there

is answering questions and asking questions. And it's a community that really centers around learning, helping each other and anything you guys have questions related to SLU, if you join the community, post them up there. Chris and I'd be more than happy to dig in and do the best we can to answer your questions. Awesome. All right, that is it.