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Answers from the Lab

Mayo Clinic Laboratories news.mayocliniclabs.com
A Mayo Clinic curated podcast sharing Mayo Clinic knowledge and advancements on the state of testing, science, and people who are making it happen behind the scenes.
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Episodes

Shifting from pandemic to endemic: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and CEO and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the stabilization of monkeypox and COVID-19, the shift from pandemic to endemic status, the increase in global virus outbreaks, and the role that laboratory medicine plays in this changing health envir...

Oct 06, 202212 minEp. 180

Virus outlook heading into fall: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and CEO and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice cover current trends for monkeypox and COVID-19, their thoughts as autumn begins, getting back to infection prevention basics, and a quick legislation update.

Sep 29, 202211 minEp. 179

Advocating for lab legislation: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and CEO and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the Saving Access to Laboratory Services Act (SALSA), how it is designed to mitigate harmful effects of the Protecting Access to Medicare Act (PAMA), where the legislation stands today, and how to get ...

Sep 22, 202211 minEp. 178

PIK3CA assay guides treatment of progressing breast cancer: Katherine Geiersbach, M.D.

(00:32) Could you provide a little bit of background about yourself, please? (01:01) Please give us a brief overview of the new PIK3CA assay. (02:09) Why do we offer two different tests, and when should each be ordered? (03:58) Which patients should have this testing? (04:39) Is this testing used for patients being considered for second-line treatment after first-line hormone receptor treatment? (05:20) Is there anything else you would like to add about the PIK3CA testing? (06:23) Why is it impo...

Sep 20, 20229 minEp. 177

Leading diagnostics into the future: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and CEO and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, they discuss Dr. Morice’s new role as CEO and president of Mayo Clinic Laboratories (MCL), his patient-centered vision for the future, and how MCL is leading positive changes in the diagnostics industry.

Sep 19, 202213 minEp. 176

PCD test provides definitive diagnosis of a rare disease: Joseph Maleszewski, M.D., and Marie-Christine Aubry, M.D.

(00:31) Could each of you please provide a little bit of background about yourself? (01:18) Let's start with a general definition of primary ciliary dyskinesia (PCD) for our audience. (02:21) PCD is rare. Dr. Maleszewski, can you talk about the implications of that? (02:39) What is the current state of PCD diagnosis in the U.S. and globally, and what are the implications for patient care? (03:37) Can you say a bit more about Mayo Clinic's diagnostic approach to PCD? (05:16) Mayo Clinic is the fi...

Sep 15, 20229 minEp. 175

PETH: Paul Jannetto, Ph.D.

(00:32) Would you mind sharing a bit about yourself and your background? (01:44) Would it be fair to say you're an expert on this topic? (01:57) Could you help us understand the role of laboratory testing in supporting recovery from alcohol use disorders, and how to approach testing for those patients? (04:50) Could you help us understand our new direct alcohol biomarker test and its benefits? (07:57) What other tests are available, and how do they compare with this biomarker?...

Sep 13, 202210 minEp. 174

Looking at the big picture: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and CEO and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss current challenges in lab medicine and what it means to be a laboratory leader, including innovation, test stewardship, and the use of digital pathology.

Sep 08, 202213 minEp. 173

Precision therapeutics can individualize depression treatment: Ann Moyer, M.D., Ph.D., and Paul Jannetto, Ph.D.

(00:31) Can you both tell us a little bit about yourselves and your backgrounds? Dr. Moyer, do you want to start? (01:51) Your background, Dr. Janetto? (02:47) Please provide an overview of major depressive disorder and the test that Mayo Clinic Laboratories has available for therapeutic drug monitoring as well as pharmacogenomics. (07:05) Which patients should have this testing, and when should it be performed? (11:33) What alternative test options are available, and how do they compare? (15:37...

Sep 06, 202219 minEp. 172

State-of-the-art genetics panel optimizes kidney disease treatment: Linnea M. Baudhuin, Ph.D., and Emily K. Thoreson, M.S., CGC

(00:31) Would each of you share a little about yourselves and your backgrounds? (01:17) Could you please provide us with an overview of what types of genetic testing for inherited kidney diseases are available Mayo Clinic Labs? (02:35) Can you expand on why genetic testing for kidney disease is important? (04:30) Who could benefit from genetic testing for inherited kidney diseases? (05:55) What types of variants are detected by these new genetic panels at Mayo Clinic Labs? (07:05) How would you ...

Aug 30, 202212 minEp. 171

Monkeypox and legislation updates: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the latest monkeypox developments, potential scenarios for monkeypox moving forward, and where the VALID Act stands.

Aug 25, 202215 minEp. 169

CIDP: Divyanshu (Div) Dubey, M.B.B.S.

(00:32) Would you mind telling our listeners a little about yourself and your background? (01:16) This evaluation is about CIDP — chronic inflammatory demyelinating polyneuropathy, correct? (02:16) Can you give us an overview of what the CIDP evaluation will consist of? (04:38) Our standalone test for neurofascin-155 won't change, but will be rolled into this new test along with contactin-1, correct? (06:41) This is a very rare disease with subtle clues, so does it make logical sense to pair the...

Aug 23, 202223 minEp. 168

Ongoing evolution of monkeypox: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss how monkeypox can be transmitted, the possibilities of a future Emergency Use Authorization (EUA), and access to testing.

Aug 18, 202213 minEp. 167

PMND1: John Lieske, M.D.

(00:31) Could you tell us a bit about yourself and your background? (01:11) Could you describe these new tests and when it would be appropriate to use each of them in the clinic? (03:16) Could you provide a little background on why MCL is making changes to the PLA2R test? (04:34) Could you describe the change to KDIGO guidelines and when it may be appropriate to skip the biopsy? How will these new tests help physicians implement these new guidelines in their practices?...

Aug 16, 20228 minEp. 166

Monkeypox testing progress: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss new developments in monkeypox testing, updates on the federal response, and lessons learned from managing other viruses.

Aug 11, 202211 minEp. 165

Enhanced detection of genetic mutation to optimize leukemia treatment: Rong He, M.D.

(00:32) Could you please provide a bit about yourself and your background? (01:39) Could you please give a basic overview of the NPM1Q test and why we are so pleased to offer it? (06:56) Which patients should have this test and when should it be performed? Is it when they are initially diagnosed? (09:44) How would translocation 8;21 and inversion 16 tests be incorporated into testing for patients? (10:41) How are the results used in patient care? (13:41) What alternative tests options are availa...

Aug 09, 202220 minEp. 164

Operationalizing monkeypox testing: John Osborn

John Osborn, operations administrator in the Department of Laboratory Medicine and Pathology at Mayo Clinic, joins the "Answers From the Lab" podcast for a discussion with host Bobbi Pritt, M.D. about monkeypox testing. In this episode, John and Dr. Pritt discuss how Mayo Clinic swiftly operationalized monkeypox testing and the challenges involved with supporting the new assay, including staffing. If the work discussed in the episode interests you, we’d love to have you join our team. If you are...

Aug 04, 202215 minEp. 163

Nonradioactive assay helps diagnose heparin reaction: Rajiv Pruthi, M.B.B.S.

(01:51) Can you give a brief overview of the assay you developed and how it works? (06:28) The serotonin release assay is utilized within five to 14 days of heparin exposure. Is there a subsequent time when this test would be utilized? (10:28) How does this assay improve upon previous approaches? (12:58) Is there greater specificity and sensitivity with the use of nonradioactive materials? (13:46) What interesting findings have we had through the process of developing and validating this assay?...

Aug 02, 202215 minEp. 162

Monkeypox declared a global public health emergency: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the World Health Organization’s declaration of monkeypox as a global public health emergency, how Mayo Clinic Laboratories quickly implemented testing, and the public-private partnership to manage the ...

Jul 28, 202215 minEp. 161

FDA-approved test expands options for Alzheimer's disease: Joshua Bornhorst, Ph.D.

(00:32) Can you please tell our listeners a little about yourself and your background? (01:00) Mayo Clinic Laboratories already offers one test for Alzheimer's disease, right? (01:32) Could you tell our listeners about the new FDA-approved test that Mayo Clinic Laboratories will launch soon? (02:43) The test results will report the ratio of the amyloid isoforms, not the individual test components, right? (03:26) Does the new test require a certain tube? (04:15) Can you provide a little more deta...

Jul 26, 202213 minEp. 160

Managing the current rise in COVID cases: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the science behind the increasing COVID-19 infections, why individuals can get reinfected with different variants, and the effectiveness of the at-home antigen tests.

Jul 21, 20229 minEp. 159

Scaling monkeypox testing and the new COVID variant: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss advances in monkeypox testing, working with the CDC to scale testing and response efforts, the fast-spreading BA.5 variant of COVID-19, and how at-home testing affects the number of reported cases.

Jul 14, 202213 minEp. 158

New SALSA bill and monkeypox testing at Mayo: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the recent Department of Health and Human Services announcement that named Mayo Clinic Laboratories as one of five commercial labs to expand capacity for monkeypox testing. They also discuss newly intr...

Jun 30, 202212 minEp. 157

The Latest on Monkeypox and Lab Legislation: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss what the increasing monkeypox cases are revealing, and regulatory updates on the VALID Act and PAMA.

Jun 23, 202214 minEp. 156

The age of pandemics: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the latest developments in monkeypox, the reality of living in the age of pandemics, and the importance of testing and public-private partnerships.

Jun 16, 202210 minEp. 155

WESDX: Cherisse Marcou, Ph.D., and Marissa Ellingson, M.S., CGC

(00:32): Before we jump in, would each of you share a little bit about your background and yourselves? (01:18): Dr. Marcou. could you provide us with an overview of what the WESDX test is? (01:50): Marissa, would you help explain why this test is important? (03:10): In your experience who would benefit from WESDX, (05:12): How does a provider order A WES DX and secondarily what type of samples are accepted? (06:24): What types of variants are detected by the test? (07:47): There are a lot of exo...

Jun 14, 202211 minEp. 154

Monkeypox: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice consider the recent uptick in cases of monkeypox and what labs can do to help facilitate accurate diagnosis of it and other viral infections.

Jun 09, 202214 minEp. 153

Being Mindful of Mental Health: John Black, M.D.

John Black, M.D., co-director of the Personalized Genomics Lab at Mayo Clinic, joins the "Answers From the Lab" podcast for a discussion with Bobbi Pritt, M.D., about mental health awareness. In this episode, Dr. Black and Dr. Pritt review key takeaways from Mental Health Awareness Month, the role that lab testing plays in mental health, and the robust science behind treatment.

Jun 07, 202219 minEp. 152

Viruses and variants: Dr. Bill Morice

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins the "Answers From the Lab" podcast for his weekly leadership update with Bobbi Pritt, M.D. In this episode, Dr. Morice and Dr. Pritt discuss the range of emerging viruses and their variants that are currently in the news.

Jun 02, 202213 minEp. 151

Recent Outbreaks of Viral Infections: Dr. Matt Binnicker

Matthew Binnicker, Ph.D., director of Mayo Clinic’s Clinical Virology Laboratory, joins the "Answers From the Lab" podcast for a discussion with Bobbi Pritt, M.D. about recent outbreaks of viral infections. In this episode, Dr. Binnicker and Dr. Pritt look at the hepatitis cases in children possibly linked to adenovirus as well as the spread of Monkeypox.

May 31, 202214 minEp. 150
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