Dr. Vinod Rao (Massachusetts General Hospital, Boston) join AJP Audio to discuss predicting the relative risk of patients with an ADHD diagnosis developing a later stimulant or substance use disorder based on the method of prescription, in person or via telehealth. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of the Journal. 00:07 Rao interview 01:53 Stimulant use disorder versus substance use disorder 02:59 Cohort size and incidence of SUDs 04:28 Length o...
Aug 01, 2025•34 min
Dr. Tanner Bommersbach (University of Wisconsin School of Medicine and Public Health) and Dr. Greg Rhee (University of Connecticut and Yale University School of Medicine) join AJP Audio to discuss estimating national trends in suicidal ideation and attempts in high school students with and without accompanying high-risk behaviors. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of the Journal. 00:07 Bommersbach and Rhee interview 00:36 Trends in suicide among h...
Jul 01, 2025•25 min
Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who might develop postpartum depression. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the June issue into context. 00:31 Perlis interview 02:56 Lack of validation in screening methods 04:03 Stumbling blocks on the road to validation 05:10 Synergy between screening scores and m...
Jun 01, 2025•33 min
Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context. 00:38 Ruggiero interview 03:13 Bounce Back Now app 05:03 Natural disasters and other sources of trauma 07:31 Low cost and broad-based inter...
May 01, 2025•36 min
Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:32 Mancini interview 02:26 Anticholinergic burden method of action 02:58 Balancing the impact of side effects in schizophrenia treatment 04:52 Limitations 05:34 The need for further studies 05:59 Clinical implications 06:32 Further research 07:01 Trials...
Apr 01, 2025•23 min
Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder , which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:45 Horan interview 03:15 Novel mechanism of action in the treatment of schizophrenia 05:39 Side effect profiles 07:20 Clinical impacts 08:31 The need for further investigation 09:58 Limitations 11:05 Further r...
Mar 01, 2025•32 min
Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction. 00:35 King interview 00:45 Allostatic model of addiction 02:12 Gathering data and the groups studied 07:37 The et...
Feb 01, 2025•45 min
Dr. Charles Nemeroff (University of Texas at Austin) joins AJP Editor-in-Chief Dr. Ned Kalin to discuss the January issue of the American Journal of Psychiatry. Dr. Nemeroff is a guest editor of the special issue, which takes a close look at the potential, pitfalls, and clinicial implications of psychedelics in mental health treatment. 00:38 Nemeroff interview 02:27 McIntyre et al. 04:06 Ramaekers et al. 05:44 Ghaznavi et al. 08:01 Fonzo et al. 09:17 Wolfgang et al. 10:45 Psychedelics and psycho...
Jan 01, 2025•19 min
Devon Grey and David Knight (University of Alabama, Birmingham) join AJP Audio to discuss how exposure to discrimination impacts neural reactivity to stress and psychological distress in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins us to discuss the rest of the December issue of AJP. 00:36 Grey and Knight interview 02:41 Demographics of the cohort 03:46 Neurobiological mechanisms of discrimination impacts 06:14 Racial discrimination and mental health impacts 09:34 Discriminat...
Dec 01, 2024•30 min
Dr. Phuc Le (Cleveland Clinic, Case Western Reserve University, Cleveland) joins AJP Audio to discuss racial, ethnic, and sociodemographic disparities in treatment in alcohol use disorder among participants of the All of Us cohort. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the November issue, which takes a close look at issues surrounding substance use disorders. 00:41 Le interview 01:52 Disparities in treatment of AUDs in the US 03:43 What is the VA system doing...
Nov 01, 2024•28 min
Dr. Bodyl Brand (Oxford University, UK) joins AJP Audio to discuss the effectiveness of menopausal hormone therapy in preventing psychosis relapse in women with schizophrenia and schizoaffective disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the October issue of the American Journal of Psychiatry, which focuses on other issues touching psychosis and schizophrenia spectrum disorders. 01:05 Brand interview 03:08 MHT and potential side effects in schizophrenia ...
Oct 01, 2024•36 min
Dr. Jessica Salvatore (Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey) joins AJP Audio to discuss peer social genetic effects and their impact on alcohol and substance use, anxiety, and major depressive disorders in adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the rest of the September issue of the American Journal of Psychiatry. 00:52 Salvatore interview 02:49 Can the genetic makeup of other people impact your risk for psychiatric conditions...
Sep 01, 2024•30 min
Dr. Evan Krueger (Tulane University School of Social Work) joins AJP Audio to discuss the impact of sexual identity change and continuity on the mental health and substance use of adults who identify as a sexual minority. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the August issue of AJP. 00:52 Krueger interview 02:49 The Generations Study 04:21 How the sample differed 05:42 Differences between male and female, monosexual and plurisexual 07:53 Clinical implications for t...
Aug 01, 2024•30 min
Dr. Lina Jonsson (Sahlgrenska Academy at University of Gothenburg, Sweden) joins AJP Audio to discuss the association of occupational dysfunction and hospital admissions with polygenic profiles in patients with bipolar disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the July issue of AJP. 00:45 Jonsson interview 04:35 Occupational dysfunction and hospitalization in bipolar disorder 05:29 Crossover between groups in patients with schizophrenia spectrum disorder 06:37...
Jul 01, 2024•31 min
Ms. Sara Tramazzo (Stony Brook University) joins AJP Audio to discuss the long-term outlook for patients with schizophrenia spectrum disorders and other psychotic disorders over the course of 25 years. Afterwards, Dr. Ned Kalin joins to discuss the rest of the June issue of AJP. 00:50 Tramazzo interview 01:55 Lower levels of recovery and remission than other long-term studies 03:01 Difficulties of following patients in long-term studies 04:35 Differences between recovery and remission 05:54 Clin...
Jun 01, 2024•29 min
Dr. ReJoyce Green (Medical University of South Carolina, Charleston, SC) joins AJP Audio to discuss predictors of substance use initiation in a large cohort of early adolescents. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin speaks with AJP Deputy Editor Dr. Kathleen Brady about the May issue of AJP, a special issue guest edited by Dr. Brady focusing on latest developments in the understanding and treatment of substance use disorders. Transcript 00:48 Green interview 03:04 Why is it important to...
May 06, 2024•37 min
Dr. Soonjo Hwang (University of Nebraska Medical Center) joins AJP Audio to discuss the response to intranasally-administered oxytocin in youths with severe irritability. 00:56 Hwang interview 02:09 Effects of oxytocin 05:45 Intranasal oxytocin 07:04 Potential adverse effects of oxytocin 08:08 Imaging 08:58 Preliminary investigations and clinical implications 09:51 Limitations 10:14 Further research 11:00 Kalin interview 11:33 Hwang et al. 14:43 Leibenluft et al. 15:39 Aggarwal et al. 18:22 Pezz...
Apr 01, 2024•28 min
Dr. Drew Rothenberg (Duke University, Durham, NC) joins AJP Audio to discuss the long term, intergenerational impacts of the Fast Track program, and whether the mental health intervention lead to lasting improvements in mental health, including in the participants own children. 00:49 Rothenberg interview 04:36 A null result? 07:13 At risk children from high risk neighborhoods 08:00 Limitations 09:17 Demand for childhood mental health services and clinical implications 11:10 Further research 13:5...
Mar 01, 2024•28 min
Dr. Ofir Livne (Columbia University, New York) joins AJP Audio to discuss recent trends in the prevalence of cannabis use disorder in US veterans with and without psychiatric disorder diagnosis. Dr. Ned Kalin joins afterwards to discuss how the rest of the February issue of AJP touches on cannabis use disorder and other substance use disorders. 00:31 Livne interview 03:16 Changes in the legal landscape surrounding cannabis use 05:17 The complex association between cannabis use and psychiatric di...
Feb 01, 2024•22 min
Dr. Jaclyn Ross, Ms. Jordan Barone, and Dr. Tory Eisenlohr-Moul (University of Illinois at Chicago) join AJP Audio to discuss the impact of the menstrual cycle on suicide ideation and planning in psychiatric patients with suicidality. Afterwards, American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin brings us up to date on the rest of the January issue of AJP . Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcast...
Jan 01, 2024•35 min
Dr. Aaron Samuel Breslow (Montefiore Medical Center and Albert Einstein College of Medicine) joins AJP Audio to discuss the racial and ethnic disparities in the impact of COVID-19 and pandemic related stressors and adverse mental health outcomes on health care workers in the Bronx, New York. Following we’ll once again check in with American Journal of Psychiatry Editor-in-Chief Dr. Ned Kalin on the rest of the December issue of AJP. Breslow interview [00:56] Why look at the Bronx in particular? ...
Dec 01, 2023•28 min
Dr. Winston Chung (Kaiser Permanente Northern California) joins AJP Audio to discuss inequalities in the diagnosis of psychotic disorders between racial and ethnic groups in a large cohort. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the November issue of AJP, which focuses on different aspects of psychotic disorder. Chung interview [00:30] Structural racism and missing socioeconomic strata [02:58] Effective and ...
Nov 01, 2023•20 min
Dr. Luis Farhat and Dr. Guilherme V. Polanczyk (University of São Paulo, Brazil) join AJP Audio to discuss the impact of socioenviromental factors, emotional dysregulation, and other factors impact neurodevelopment in children. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Farhat and Polanczyk interview [00:54] Comorbidities and associations [03:22] Twins Earl...
Oct 01, 2023•29 min
Dr. Antony Chum (York University, Toronto) joins AJP Audio to discuss disparities in suicide-related behaviors between sexual orientations by gender in a large cohort from the province of Ontario. Afterwards, we’ll once again be joined by American Journal of Psychiatry Editor-in-Chief, Dr. Ned Kalin, to discuss the rest of the September issue of AJP and what brings it together. Transcript Chum interview [00:34] Results [02:14] Using a large data set [03:21] Correcting the limitations of previous...
Sep 01, 2023•24 min
Dr. Lucy S. King (Tulane University School of Medicine, New Orleans) and Dr. Kathryn L. Humphreys (Vanderbilt University, Nashville) join AJP Audio to discuss the long term impacts of a pioneering randomized controlled trial that looked at the impacts of institutional care versus home foster care in children, the Bucharest Early Intervention Project. They also discuss the impacts of deprivation on children’s development and mental health, and the thorny ethics of research involving children. Tra...
Aug 01, 2023•33 min
Dr. Dylan J. Jester (VA Palo Alto Medical Center in Palo Alto, California) joins AJP Audio to discuss the differential impact of selected social determinants of health on the mental health outcomes of older Black, White, and Latinx adults in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the July issue. Transcript Jester interview [00:48] Which social determinants of health did you focus on? [03:31] Societ...
Jul 01, 2023•22 min
Dr. Mark Olfson (Columbia University) discusses the links between opioid prescribing and suicide risk in the United States. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses how issues of substance use disorder draw together the rest of the June issue. Transcript Olfson interview [00:46] Geographic commuting areas [01:06] Opioid prescription measures [02:10] Rates of opioid prescription and suicide [03:27] Youngest age cohorts as outliers [04:19] Regional variations [04:57] Limitations [05...
Jun 01, 2023•16 min
Ms. Gal Arad (Tel Aviv University, Tel Aviv, Israel) discusses a non-pharmacological intervention for the treatment of social anxiety disorder in comparison with standard care. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the May issue. Transcript Arad interview [00:18] What were your results? [02:11] Reduction in dwell time on threatening faces [03:36] Limitations [04:09] Immediate clinical implications [05:27] Further research [05:58] Kalin...
May 01, 2023•20 min
Dr. David G. Amaral (University of California, Davis) is an author of a review paper in the April issue of AJP looking at the use of animal models and other forms of translational neuroscience in the investigation of autism spectrum disorder. He joins us on AJP Audio to discuss it. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the April issue. Transcript Amaral interview [00:56] Advantages and disadvantages of animal model research [02:14] Wha...
Apr 03, 2023•30 min
Dr. Gary S. Sachs (Harvard Medical School) joins us for the for the March episode of AJP Audio , discussing the results from a phase 3 study looking at the use of atypical antipsychotic cariprazine as an adjunctive treatment for major depression in conjunction with antidepressants. Afterwards, we’ll be joined once again by AJP Editor-in-Chief Dr. Ned Kalin to discuss the rest of the March issue. Transcript Sachs interview [00:47] Why is treating major depressive disorder in patients proven to be...
Mar 01, 2023•24 min
